2017 Vol. 35, No. 4
Display Method:
2017, 35(4): 289-293.
doi: 10.3969/j.issn.1006-0111.2017.04.001
Abstract:
The TNF-α signaling pathway is a valuable target in the therapy of autoimmune diseases. TNF-α binds to two different receptors and exerts anti-inflammatory and anti-rheumatic effects. The drugs of anti-TNF-α are widely used in rheumatoid arthritis, s...
The TNF-α signaling pathway is a valuable target in the therapy of autoimmune diseases. TNF-α binds to two different receptors and exerts anti-inflammatory and anti-rheumatic effects. The drugs of anti-TNF-α are widely used in rheumatoid arthritis, s...
2017, 35(4): 294-297,345.
doi: 10.3969/j.issn.1006-0111.2017.04.002
Abstract:
The incident number and death toll of cardio-cerebrovascular diseases increase continuously in China. The impairment of arterial baroreflex (ABR) is closely related to the genesis and development of cardio-cerebrovascular diseases (such as hypertensi...
The incident number and death toll of cardio-cerebrovascular diseases increase continuously in China. The impairment of arterial baroreflex (ABR) is closely related to the genesis and development of cardio-cerebrovascular diseases (such as hypertensi...
2017, 35(4): 298-300,314.
doi: 10.3969/j.issn.1006-0111.2017.04.003
Abstract:
In recent years, with the wide use of antimicrobial agents, the adverse reactions related to antimicrobial agents have attracted more and more attention.Among them, the adverse reactions in hematological system induced by antibacterial agents serious...
In recent years, with the wide use of antimicrobial agents, the adverse reactions related to antimicrobial agents have attracted more and more attention.Among them, the adverse reactions in hematological system induced by antibacterial agents serious...
2017, 35(4): 301-303,333.
doi: 10.3969/j.issn.1006-0111.2017.04.004
Abstract:
Monoclonal antibodies have become an important part of biotechnology and pharmaceutical industry. Currently chimeric antibody, humanized antibody and fully human antibody are generally prepared by genetic engineering. With constant improvement in the...
Monoclonal antibodies have become an important part of biotechnology and pharmaceutical industry. Currently chimeric antibody, humanized antibody and fully human antibody are generally prepared by genetic engineering. With constant improvement in the...
2017, 35(4): 304-307.
doi: 10.3969/j.issn.1006-0111.2017.04.005
Abstract:
Objective To screen the active compounds targeting lung cancer stem cells (LCSCs) from the sponge Aaptos aaptos. Methods The A549-Nanog-GFP model of LCSCs was constructed. Western blot and immunofluorescence were used to examine the expression of ...
Objective To screen the active compounds targeting lung cancer stem cells (LCSCs) from the sponge Aaptos aaptos. Methods The A549-Nanog-GFP model of LCSCs was constructed. Western blot and immunofluorescence were used to examine the expression of ...
2017, 35(4): 308-314.
doi: 10.3969/j.issn.1006-0111.2017.04.006
Abstract:
Objective To investigate the chemical constituents of marine sponge Mycale sp. collected from the South China Sea. Methods The ethyl acetate extract of the marine sponge Mycale sp. was separated and purified by repeated column chromatography on si...
Objective To investigate the chemical constituents of marine sponge Mycale sp. collected from the South China Sea. Methods The ethyl acetate extract of the marine sponge Mycale sp. was separated and purified by repeated column chromatography on si...
2017, 35(4): 315-320,382.
doi: 10.3969/j.issn.1006-0111.2017.04.007
Abstract:
Objective To investigate the chemical constituents in the marine sponge, Spongia sp., collected from the Xisha Islands. Methods The pure chemical components from the petroleum ether extract of Spongia sp.were obtained by repeated column chromatogr...
Objective To investigate the chemical constituents in the marine sponge, Spongia sp., collected from the Xisha Islands. Methods The pure chemical components from the petroleum ether extract of Spongia sp.were obtained by repeated column chromatogr...
2017, 35(4): 321-324,366.
doi: 10.3969/j.issn.1006-0111.2017.04.008
Abstract:
Objective To prepare an in situ gel system for nasal delivery of menthol and to evaluate the safety of this formulation. Methods Menthol in situ gel was prepared with deacetylatedgellan gum. The nasal mucocilia toxicities of this formulation was e...
Objective To prepare an in situ gel system for nasal delivery of menthol and to evaluate the safety of this formulation. Methods Menthol in situ gel was prepared with deacetylatedgellan gum. The nasal mucocilia toxicities of this formulation was e...
2017, 35(4): 325-327,349.
doi: 10.3969/j.issn.1006-0111.2017.04.009
Abstract:
Objective To prepare diosmin suppository and establish a method for its quality control. Methods Diosmin was used as active ingredient. Polyethylene glycol 6000, polyethylene glycol 400 and glycerol were chosen as substrates. Fusion method was app...
Objective To prepare diosmin suppository and establish a method for its quality control. Methods Diosmin was used as active ingredient. Polyethylene glycol 6000, polyethylene glycol 400 and glycerol were chosen as substrates. Fusion method was app...
2017, 35(4): 328-333.
doi: 10.3969/j.issn.1006-0111.2017.04.010
Abstract:
Objective To develop a method for determination of iridoid glycosides in Morinda of ficinalis How. and optimize the extraction methods for iridoid glycosides in Morinda of ficinalis How. Methods The iridoid glycosides, including monotropein, deace...
Objective To develop a method for determination of iridoid glycosides in Morinda of ficinalis How. and optimize the extraction methods for iridoid glycosides in Morinda of ficinalis How. Methods The iridoid glycosides, including monotropein, deace...
2017, 35(4): 334-336,370.
doi: 10.3969/j.issn.1006-0111.2017.04.011
Abstract:
Objective To test the acute toxicity and determine the safe dose range of Moringa oleifera leaves and seeds. Methods Acute toxicity tests were performed based on the documented experimental designs in Research Methods of Pharmacology of Chinese ...
Objective To test the acute toxicity and determine the safe dose range of Moringa oleifera leaves and seeds. Methods Acute toxicity tests were performed based on the documented experimental designs in Research Methods of Pharmacology of Chinese ...
2017, 35(4): 337-340,358.
doi: 10.3969/j.issn.1006-0111.2017.04.012
Abstract:
Objective To investigate the effect of Euphorbia helioscopia on MDA-MB-231 cells and its mechanism. Methods The cell viability was detected by MTT assay. The production of ROS in MDA-MB-231 cells was measured by fluorescence microscopy. The apopto...
Objective To investigate the effect of Euphorbia helioscopia on MDA-MB-231 cells and its mechanism. Methods The cell viability was detected by MTT assay. The production of ROS in MDA-MB-231 cells was measured by fluorescence microscopy. The apopto...
2017, 35(4): 341-345.
doi: 10.3969/j.issn.1006-0111.2017.04.013
Abstract:
Objective To simplify the calculation of T>MIC and evaluate meropenem regimens based on the simple mathematical model of T>MIC reported in literature for two-compartment model. Methods Six meropenem regimens were designed according to the recommen...
Objective To simplify the calculation of T>MIC and evaluate meropenem regimens based on the simple mathematical model of T>MIC reported in literature for two-compartment model. Methods Six meropenem regimens were designed according to the recommen...
2017, 35(4): 346-349.
doi: 10.3969/j.issn.1006-0111.2017.04.014
Abstract:
Objective To develop a UPLC-MS method for the determination of pazopanib in rat plasma, and study the pharmacokinetics of pazopanib in rats. Methods The effective UPLC MS/MS separation of the examined compounds was applied on an Acquity BEH C18 co...
Objective To develop a UPLC-MS method for the determination of pazopanib in rat plasma, and study the pharmacokinetics of pazopanib in rats. Methods The effective UPLC MS/MS separation of the examined compounds was applied on an Acquity BEH C18 co...
2017, 35(4): 350-352,384.
doi: 10.3969/j.issn.1006-0111.2017.04.015
Abstract:
Objective To establish the quality standard of Santeng oral solution. Method Sargentodoxa Caulis and Spatholobi Caulis were identified by thin layer chromatography. Chlorogenic acid was assayed by high performance liquid chromatography. The chromato...
Objective To establish the quality standard of Santeng oral solution. Method Sargentodoxa Caulis and Spatholobi Caulis were identified by thin layer chromatography. Chlorogenic acid was assayed by high performance liquid chromatography. The chromato...
2017, 35(4): 353-354,378.
doi: 10.3969/j.issn.1006-0111.2017.04.016
Abstract:
Objective To establish a HPLC method for determination of berberine hydrochloride in Dongbai Tonglin Heji. Methods The separation column of Kromasil C18(150 mm×4.6 mm,5 μm) was used. The mobile phase was acetonitrile and 0.05 mol/L NaH2PO4 solutio...
Objective To establish a HPLC method for determination of berberine hydrochloride in Dongbai Tonglin Heji. Methods The separation column of Kromasil C18(150 mm×4.6 mm,5 μm) was used. The mobile phase was acetonitrile and 0.05 mol/L NaH2PO4 solutio...
2017, 35(4): 355-358.
doi: 10.3969/j.issn.1006-0111.2017.04.017
Abstract:
Objective To establish the quality standard for YI SHI MINGMU granules. Methods TLC method was used to identify Lycium barbarum L and Salvia miltiorrhiza. HPLC method was used to quantitatively analyze the concentration of Tanshinol sodium. The an...
Objective To establish the quality standard for YI SHI MINGMU granules. Methods TLC method was used to identify Lycium barbarum L and Salvia miltiorrhiza. HPLC method was used to quantitatively analyze the concentration of Tanshinol sodium. The an...
Determination of madecassoside and asiaticoside in Centella asiatica formula granules by HPLC method
2017, 35(4): 359-361.
doi: 10.3969/j.issn.1006-0111.2017.04.018
Abstract:
Objective To establish a HPLC method for determination of madecassoside and asiaticoside in Centella asiatica formula granules. Methods Chromatographic separation was performed on Ultimate AQ-C18 column(4.6 mm×250 mm,5 μm) with mobile phase of ace...
Objective To establish a HPLC method for determination of madecassoside and asiaticoside in Centella asiatica formula granules. Methods Chromatographic separation was performed on Ultimate AQ-C18 column(4.6 mm×250 mm,5 μm) with mobile phase of ace...
2017, 35(4): 362-366.
doi: 10.3969/j.issn.1006-0111.2017.04.019
Abstract:
Hepatocellular carcinoma is a malignant tumor with high morbidity and mortality globally. The therapeutic results on hepatocellular carcinoma with surgery and other classical treatments are not satisfactory. Tumor immunotherapies, such as dendritic c...
Hepatocellular carcinoma is a malignant tumor with high morbidity and mortality globally. The therapeutic results on hepatocellular carcinoma with surgery and other classical treatments are not satisfactory. Tumor immunotherapies, such as dendritic c...
2017, 35(4): 367-370.
doi: 10.3969/j.issn.1006-0111.2017.04.020
Abstract:
Objective To optimize the treatment plan for dermatitis medicamentosa in a patient with abnormal liver function associated with infection. Methods The culprit medication for drug eruption was identified by reviewing the patient's liver and kidney ...
Objective To optimize the treatment plan for dermatitis medicamentosa in a patient with abnormal liver function associated with infection. Methods The culprit medication for drug eruption was identified by reviewing the patient's liver and kidney ...
2017, 35(4): 371-374.
doi: 10.3969/j.issn.1006-0111.2017.04.021
Abstract:
Objective To discuss the knowledge and skills that clinical pharmacist should master to successfully perform the work in Department of Critical Care Medicine. Methods To illustrate the problem solving process with case studies in critical care set...
Objective To discuss the knowledge and skills that clinical pharmacist should master to successfully perform the work in Department of Critical Care Medicine. Methods To illustrate the problem solving process with case studies in critical care set...
2017, 35(4): 375-378.
doi: 10.3969/j.issn.1006-0111.2017.04.022
Abstract:
Objective To evaluate the cost and effectiveness for five combination therapy of β-lactam antibiotic with azithromycin in the treatment of mycoplasma pneumonia (MP) complicated with bacterial infection. Methods A retrospective study was conducted ...
Objective To evaluate the cost and effectiveness for five combination therapy of β-lactam antibiotic with azithromycin in the treatment of mycoplasma pneumonia (MP) complicated with bacterial infection. Methods A retrospective study was conducted ...
2017, 35(4): 379-382.
doi: 10.3969/j.issn.1006-0111.2017.04.023
Abstract:
Objective To promote the rational antibacterial drug use for common digestive system (DS) diseases by reviewing the clinical application of antibacterial drugs for hospitalized patients, formulating the hospital clinical specification of antibacteri...
Objective To promote the rational antibacterial drug use for common digestive system (DS) diseases by reviewing the clinical application of antibacterial drugs for hospitalized patients, formulating the hospital clinical specification of antibacteri...
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