2016 Vol. 34, No. 2
Display Method:
2016, 34(2): 97-102.
doi: 10.3969/j.issn.1006-0111.2016.02.001
Abstract:
With the development of science and the progress of age, medicinal chemistry is not only limited to the lead discovery and the structure-activity relationship studies, but also finding the target of bioactive small molecule drugs has become a tough i...
With the development of science and the progress of age, medicinal chemistry is not only limited to the lead discovery and the structure-activity relationship studies, but also finding the target of bioactive small molecule drugs has become a tough i...
Progress on nano-sized drug delivery system reversing tumor and multidrug resistance of osteosarcoma
2016, 34(2): 103-105.
doi: 10.3969/j.issn.1006-0111.2016.02.002
Abstract:
Multidrug resistance(MDR) of tumor cell is the major problem for chemotherapy. However, there is no effective strategy to overcome MDR due to the complicated mechanism. The nano-sized drug delivery system could target to the tumor cell. Moreover, it ...
Multidrug resistance(MDR) of tumor cell is the major problem for chemotherapy. However, there is no effective strategy to overcome MDR due to the complicated mechanism. The nano-sized drug delivery system could target to the tumor cell. Moreover, it ...
2016, 34(2): 106-109.
doi: 10.3969/j.issn.1006-0111.2016.02.003
Abstract:
Triazoles are the most widely used antifungal drugs in clinic with broad spectrum and high efficacy, which targets sterol 14α-demethylase(CYP51), an enzyme expressed by the gene EGR 11, which is a key enzyme in the fungi ergosterol biosynthesis. On t...
Triazoles are the most widely used antifungal drugs in clinic with broad spectrum and high efficacy, which targets sterol 14α-demethylase(CYP51), an enzyme expressed by the gene EGR 11, which is a key enzyme in the fungi ergosterol biosynthesis. On t...
2016, 34(2): 110-113,128.
doi: 10.3969/j.issn.1006-0111.2016.02.004
Abstract:
Fluconazole, the third generation of triazole-antifungal drug, becomes the first choice in the treatment of fungal infection due to its broad antifungal spectrum, good water solubility and low toxicity. With an increasingly drug-resistant strain, dev...
Fluconazole, the third generation of triazole-antifungal drug, becomes the first choice in the treatment of fungal infection due to its broad antifungal spectrum, good water solubility and low toxicity. With an increasingly drug-resistant strain, dev...
2016, 34(2): 114-115,134.
doi: 10.3969/j.issn.1006-0111.2016.02.005
Abstract:
Oridonin is an en-kaurene diterpenoids compound which was found to have effect on tumor in vitro. But the clinical application has been limited because of poor water solubility, low bioavailability and oral absorption. Many scholars conducted a large...
Oridonin is an en-kaurene diterpenoids compound which was found to have effect on tumor in vitro. But the clinical application has been limited because of poor water solubility, low bioavailability and oral absorption. Many scholars conducted a large...
2016, 34(2): 116-118,173.
doi: 10.3969/j.issn.1006-0111.2016.02.006
Abstract:
Pathogenic Candida albicans has a high degree of adaptability to environment, which is evidenced by its adaptability to various conditions, including its symbiosis with the host, growth in host tissues during invasion, and survival under antifungal t...
Pathogenic Candida albicans has a high degree of adaptability to environment, which is evidenced by its adaptability to various conditions, including its symbiosis with the host, growth in host tissues during invasion, and survival under antifungal t...
2016, 34(2): 119-123.
doi: 10.3969/j.issn.1006-0111.2016.02.007
Abstract:
The inflammation and apoptosis were vital important in the progress and recovery in myocardial infarction. Apoptosis was regulated by inflammation though TNF-α, CHOP, IL-10 and α7nAChR signal pathways and influenced the severity of the inflammation v...
The inflammation and apoptosis were vital important in the progress and recovery in myocardial infarction. Apoptosis was regulated by inflammation though TNF-α, CHOP, IL-10 and α7nAChR signal pathways and influenced the severity of the inflammation v...
Advances on the research of the pharmacological activity mechanism and toxicology of Glaucocalyxin A
2016, 34(2): 124-128.
doi: 10.3969/j.issn.1006-0111.2016.02.008
Abstract:
Glaucocalyxin A(GLA) is a kind of diterpenoid enantiomers with organic chemical structure of en-15-oxo-16-kaurene. It has various pharmacological activities, such as cardiovascular and endothelium cellular protection, anti-blood coagulation, anti-Hep...
Glaucocalyxin A(GLA) is a kind of diterpenoid enantiomers with organic chemical structure of en-15-oxo-16-kaurene. It has various pharmacological activities, such as cardiovascular and endothelium cellular protection, anti-blood coagulation, anti-Hep...
2016, 34(2): 129-134.
doi: 10.3969/j.issn.1006-0111.2016.02.009
Abstract:
Objective 3,4-Methylenedioxyphenethylamine and caffeic acid derivatives have been proven previously in our group to produce activity against drug resistant fungi synergistic with fluconazole(FCZ). The two pharmacophores were coupled by amino acids a...
Objective 3,4-Methylenedioxyphenethylamine and caffeic acid derivatives have been proven previously in our group to produce activity against drug resistant fungi synergistic with fluconazole(FCZ). The two pharmacophores were coupled by amino acids a...
2016, 34(2): 135-137.
doi: 10.3969/j.issn.1006-0111.2016.02.010
Abstract:
Objective To improve the synthesis process of chlorine f(1). Methods A "one-pot" method was applied to prepare Photosensitizer component(1), using pheophorbide a(3) as raw material by oxidating and cracking of the E-ring of(3) with bubbling oxygen...
Objective To improve the synthesis process of chlorine f(1). Methods A "one-pot" method was applied to prepare Photosensitizer component(1), using pheophorbide a(3) as raw material by oxidating and cracking of the E-ring of(3) with bubbling oxygen...
2016, 34(2): 138-141,166.
doi: 10.3969/j.issn.1006-0111.2016.02.011
Abstract:
Objective To investigate the secondary metabolites of the South China Sea spine body sponge Acanthella cavernosa. Methods The acetone extract of A. cavernosa was isolated and purified by repeated column chromatography on silica gel, sephadex LH-20...
Objective To investigate the secondary metabolites of the South China Sea spine body sponge Acanthella cavernosa. Methods The acetone extract of A. cavernosa was isolated and purified by repeated column chromatography on silica gel, sephadex LH-20...
2016, 34(2): 142-147,170.
doi: 10.3969/j.issn.1006-0111.2016.02.012
Abstract:
Objective To screen the formulation of self-microemulsifying drug delivery system(SMEDDS) for sirolimus(SRL) and prepare the SRL-SMEDDS pellets. Methods Co-emulsifier, oil phase and emulsifier were chosen by solubility test and ternary phase diagr...
Objective To screen the formulation of self-microemulsifying drug delivery system(SMEDDS) for sirolimus(SRL) and prepare the SRL-SMEDDS pellets. Methods Co-emulsifier, oil phase and emulsifier were chosen by solubility test and ternary phase diagr...
2016, 34(2): 148-152.
doi: 10.3969/j.issn.1006-0111.2016.02.013
Abstract:
Objective To prepare a novel drug delivery system camptothecin loaded nanogel(CPT-PPO gel), and investigate its contents, physical and chemical properties and in vitro transdermal permeability. Methods The solvent evaporation method was utilized t...
Objective To prepare a novel drug delivery system camptothecin loaded nanogel(CPT-PPO gel), and investigate its contents, physical and chemical properties and in vitro transdermal permeability. Methods The solvent evaporation method was utilized t...
2016, 34(2): 153-157.
doi: 10.3969/j.issn.1006-0111.2016.02.014
Abstract:
Objective To prepare paeoniflorin gastric floating tablets and to optimize the formulation. Methods Gastric floating tablets were prepared by wet granulation, with floating performance and in vitro cumulative release rate as evaluat indicators, si...
Objective To prepare paeoniflorin gastric floating tablets and to optimize the formulation. Methods Gastric floating tablets were prepared by wet granulation, with floating performance and in vitro cumulative release rate as evaluat indicators, si...
2016, 34(2): 158-162.
doi: 10.3969/j.issn.1006-0111.2016.02.015
Abstract:
Objective To improve the hydrophobic properties of the ordered mesoporous carbon nanoparticles(MCN) by PVP or DSPE-mPEG2000 modification, and to compare the effect on the dispersion and cytotoxicity of MCN before and after modification. Methods MC...
Objective To improve the hydrophobic properties of the ordered mesoporous carbon nanoparticles(MCN) by PVP or DSPE-mPEG2000 modification, and to compare the effect on the dispersion and cytotoxicity of MCN before and after modification. Methods MC...
2016, 34(2): 163-166.
doi: 10.3969/j.issn.1006-0111.2016.02.016
Abstract:
Objective To determine the concentration of eupatilin and arteanoflavone in Artemisia anomala by high performance liquid chromatography(HPLC). Methods Artemisia anomala was extracted by ultrasonic for 60 minutes with 10 times volume of methanol. T...
Objective To determine the concentration of eupatilin and arteanoflavone in Artemisia anomala by high performance liquid chromatography(HPLC). Methods Artemisia anomala was extracted by ultrasonic for 60 minutes with 10 times volume of methanol. T...
2016, 34(2): 167-170.
doi: 10.3969/j.issn.1006-0111.2016.02.017
Abstract:
Objective To establish a quality standard of Weinaxin granular. Methods Pinelliae Rhizoma,Poria,Glycyrrhizae, Radix Angelicae,Aurantii Fructus were identified by TLC,and the assay of Narigin in Aurantii Fructus was performed by reverse phase HPLC....
Objective To establish a quality standard of Weinaxin granular. Methods Pinelliae Rhizoma,Poria,Glycyrrhizae, Radix Angelicae,Aurantii Fructus were identified by TLC,and the assay of Narigin in Aurantii Fructus was performed by reverse phase HPLC....
2016, 34(2): 171-173.
doi: 10.3969/j.issn.1006-0111.2016.02.018
Abstract:
Objective To optimize novel triazole antifungal compounds synthesis of key intermediates. Methods The orthogonal experimental design is used, emphasizing on four factors including the reaction temperature, the weight ratio of material, reaction ti...
Objective To optimize novel triazole antifungal compounds synthesis of key intermediates. Methods The orthogonal experimental design is used, emphasizing on four factors including the reaction temperature, the weight ratio of material, reaction ti...
2016, 34(2): 174-176,187.
doi: 10.3969/j.issn.1006-0111.2016.02.019
Abstract:
Objective To study the fingerprint of Polygonum cuspidatum from various regions by HPLC and provide technical support for the identification. Methods HPLC conditions:the chromatographic column was Agilent ZORBAX SB-C18(4.6 mm×250 mm, 5μm); the mob...
Objective To study the fingerprint of Polygonum cuspidatum from various regions by HPLC and provide technical support for the identification. Methods HPLC conditions:the chromatographic column was Agilent ZORBAX SB-C18(4.6 mm×250 mm, 5μm); the mob...
2016, 34(2): 177-178.
doi: 10.3969/j.issn.1006-0111.2016.02.020
Abstract:
Objective To establish a method of microbial limit tests for compound Hongjingtian oral liquid and to perform the validation of the method. Methods The validation on the microbial limit test method was conducted according to the counting method of...
Objective To establish a method of microbial limit tests for compound Hongjingtian oral liquid and to perform the validation of the method. Methods The validation on the microbial limit test method was conducted according to the counting method of...
2016, 34(2): 179-180.
doi: 10.3969/j.issn.1006-0111.2016.02.021
Abstract:
Objective To discuss the measures to prevent adverse events caused by misused hyperosmolar drugs. Methods Clinical pharmacists were involved in the treatment of one case of skin necrosis caused by hyperosmolar arginine infusion, analyzing the caus...
Objective To discuss the measures to prevent adverse events caused by misused hyperosmolar drugs. Methods Clinical pharmacists were involved in the treatment of one case of skin necrosis caused by hyperosmolar arginine infusion, analyzing the caus...
2016, 34(2): 181-183.
doi: 10.3969/j.issn.1006-0111.2016.02.022
Abstract:
Objective To investigate countermeasures and effects of clinical pharmacists participating in the treatment for fluconazole-exposure candidemia, and to provide reference for infectious control in the clinic. Methods Clinical pharmacists used their...
Objective To investigate countermeasures and effects of clinical pharmacists participating in the treatment for fluconazole-exposure candidemia, and to provide reference for infectious control in the clinic. Methods Clinical pharmacists used their...
2016, 34(2): 184-187.
doi: 10.3969/j.issn.1006-0111.2016.02.023
Abstract:
Objective To introduce the process and experience of construction of medical supplies support practice training platform under informatization. Methods To review and comment the structure composition, functions implemented, applications and experi...
Objective To introduce the process and experience of construction of medical supplies support practice training platform under informatization. Methods To review and comment the structure composition, functions implemented, applications and experi...
2016, 34(2): 188-190,192.
doi: 10.3969/j.issn.1006-0111.2016.02.024
Abstract:
Objective To study the application of outpatient oral antihypertensive drugs in Shanghai Meishan Hospital, and provide a guide for clinical rational drug use. Methods The utilization of antihypertensive drugs in outpatients of our hospital was ana...
Objective To study the application of outpatient oral antihypertensive drugs in Shanghai Meishan Hospital, and provide a guide for clinical rational drug use. Methods The utilization of antihypertensive drugs in outpatients of our hospital was ana...
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