2015 Vol. 33, No. 6
Display Method:
2015, 33(6): 481-485,569.
doi: 10.3969/j.issn.1006-0111.2015.06.001
Abstract:
Objective Anthrax is an anthropozoonosis caused by the bacterium Bacillus anthracis. Bacillus anthracis is an aerobic, spore-forming, rod-shaped bacterium, which infects human through ingestion or inhalation of the spores. The exosporium of spores o...
Objective Anthrax is an anthropozoonosis caused by the bacterium Bacillus anthracis. Bacillus anthracis is an aerobic, spore-forming, rod-shaped bacterium, which infects human through ingestion or inhalation of the spores. The exosporium of spores o...
2015, 33(6): 486-489.
doi: 10.3969/j.issn.1006-0111.2015.06.002
Abstract:
The rearrangement reaction of benzyl phenyl ethers(BPE) plays an important role in the organic chemistry and drug synthesis. This paper briefly reviewed the rearrangement reaction and its possible mechanism in various catalytic systems, such as trifl...
The rearrangement reaction of benzyl phenyl ethers(BPE) plays an important role in the organic chemistry and drug synthesis. This paper briefly reviewed the rearrangement reaction and its possible mechanism in various catalytic systems, such as trifl...
2015, 33(6): 490-493,532.
doi: 10.3969/j.issn.1006-0111.2015.06.003
Abstract:
Aptamers are single stranded oligonucleotides that have high affinity and specificity towards a wide range of target molecules. Owing to the indispensable advantages, aptamers have wildly prospects and have become a research hotspot in targeted drug ...
Aptamers are single stranded oligonucleotides that have high affinity and specificity towards a wide range of target molecules. Owing to the indispensable advantages, aptamers have wildly prospects and have become a research hotspot in targeted drug ...
2015, 33(6): 494-497,512.
doi: 10.3969/j.issn.1006-0111.2015.06.004
Abstract:
Tumor diseases have attracted great attention of the society because of the increasing morbidity in recent years. To inhibit the P53-MDM2 interaction has become an important target for design of cancer drug, and a lot of peptide and small molecule in...
Tumor diseases have attracted great attention of the society because of the increasing morbidity in recent years. To inhibit the P53-MDM2 interaction has become an important target for design of cancer drug, and a lot of peptide and small molecule in...
2015, 33(6): 498-501.
doi: 10.3969/j.issn.1006-0111.2015.06.005
Abstract:
In the recent years, siRNA has been widely used as effector molecule in the field of gene therapy for cancer. In order to achieve ideal treatment effect, the key factor is to find safe, efficient, stable and controllable gene vectors. The commonly us...
In the recent years, siRNA has been widely used as effector molecule in the field of gene therapy for cancer. In order to achieve ideal treatment effect, the key factor is to find safe, efficient, stable and controllable gene vectors. The commonly us...
2015, 33(6): 502-504,517.
doi: 10.3969/j.issn.1006-0111.2015.06.006
Abstract:
Objective To discuss the antitumor effect of snake venom toxins and its application in medical field. Methods To review the research progress of composition, the antitumor effect and mechanism of snake venom toxins. Results It was demonstrated t...
Objective To discuss the antitumor effect of snake venom toxins and its application in medical field. Methods To review the research progress of composition, the antitumor effect and mechanism of snake venom toxins. Results It was demonstrated t...
2015, 33(6): 505-507,543.
doi: 10.3969/j.issn.1006-0111.2015.06.007
Abstract:
Quinolones are widely used due to the wide antimicrobial spectrum and strong activity. The common adverse reactions of quinolones include gastrointestinal disturbances, central nervous system reaction, skin reaction, etc. These adverse reactions are ...
Quinolones are widely used due to the wide antimicrobial spectrum and strong activity. The common adverse reactions of quinolones include gastrointestinal disturbances, central nervous system reaction, skin reaction, etc. These adverse reactions are ...
2015, 33(6): 508-512.
doi: 10.3969/j.issn.1006-0111.2015.06.008
Abstract:
Drug metabolism and drug-drug interactions were associated with the single nucleotide polymorphisms of CYP. The relationship between CYP2C19 polymorphisms and metabolism as well as interactions of proton pump inhibitors, voriconazole and clopidogrel ...
Drug metabolism and drug-drug interactions were associated with the single nucleotide polymorphisms of CYP. The relationship between CYP2C19 polymorphisms and metabolism as well as interactions of proton pump inhibitors, voriconazole and clopidogrel ...
2015, 33(6): 513-517.
doi: 10.3969/j.issn.1006-0111.2015.06.009
Abstract:
Objective To study the influence on common logarithm of partition-coefficient (log P) value of insoluble drugs on nano-lipid emulsion properties, including drug-loading amount, in vitro release, and phase distribution etc. Methods 6 insoluble drug...
Objective To study the influence on common logarithm of partition-coefficient (log P) value of insoluble drugs on nano-lipid emulsion properties, including drug-loading amount, in vitro release, and phase distribution etc. Methods 6 insoluble drug...
2015, 33(6): 518-521,575.
doi: 10.3969/j.issn.1006-0111.2015.06.010
Abstract:
Objective To observe the dynamic characteristics of protein kinase, casein kinase II α (CK2α), expression during hepatic fibrogenesis in rats;and the effects of a matrine derivative, 13-methylamino-18-thione-matrine (MASM), on CK2α expression when i...
Objective To observe the dynamic characteristics of protein kinase, casein kinase II α (CK2α), expression during hepatic fibrogenesis in rats;and the effects of a matrine derivative, 13-methylamino-18-thione-matrine (MASM), on CK2α expression when i...
2015, 33(6): 522-524.
doi: 10.3969/j.issn.1006-0111.2015.06.011
Abstract:
Objective To study the anti-fatigue effect of methylphenidate hydrochloride oral fast dissolving films (MPH-OFDF) and its mechanism. Methods 60 mice were randomly divided into 6 groups as: normal control group (physiological saline), model group (...
Objective To study the anti-fatigue effect of methylphenidate hydrochloride oral fast dissolving films (MPH-OFDF) and its mechanism. Methods 60 mice were randomly divided into 6 groups as: normal control group (physiological saline), model group (...
2015, 33(6): 525-528,535.
doi: 10.3969/j.issn.1006-0111.2015.06.012
Abstract:
Objective To design and synthesize novel Danshensu derivatives in order to improve their stability and cardio-protective effect against myocardial ischemia. Methods Novel Danshensu derivatives were synthesized chiefly via esterification,methoxy ph...
Objective To design and synthesize novel Danshensu derivatives in order to improve their stability and cardio-protective effect against myocardial ischemia. Methods Novel Danshensu derivatives were synthesized chiefly via esterification,methoxy ph...
2015, 33(6): 529-532.
doi: 10.3969/j.issn.1006-0111.2015.06.013
Abstract:
Objective To optimize the synthesis route of substituted quinazolinone and investigate the influence of temperature and time in the synthesis of key intermediates. Methods A parallel test was carried out to compare temperature, time and the ester ...
Objective To optimize the synthesis route of substituted quinazolinone and investigate the influence of temperature and time in the synthesis of key intermediates. Methods A parallel test was carried out to compare temperature, time and the ester ...
2015, 33(6): 533-535.
doi: 10.3969/j.issn.1006-0111.2015.06.014
Abstract:
Objective To analyze the chemical components of the liposoluble constituent of Holotrichia diomphalia larvae. Methods Essential liposoluble compounds were extracted from H.diomphalia through ethylacetate. GC-MS analysis was used to identify its ma...
Objective To analyze the chemical components of the liposoluble constituent of Holotrichia diomphalia larvae. Methods Essential liposoluble compounds were extracted from H.diomphalia through ethylacetate. GC-MS analysis was used to identify its ma...
2015, 33(6): 536-538.
doi: 10.3969/j.issn.1006-0111.2015.06.015
Abstract:
Objective To investigate the application of microemulsion thin layer chromatography (TLC) for separation and identification of various active components in Xinnaomaitong capsule. Methods The all-grass of Bluecalyx japanese rabodosia, root of Puera...
Objective To investigate the application of microemulsion thin layer chromatography (TLC) for separation and identification of various active components in Xinnaomaitong capsule. Methods The all-grass of Bluecalyx japanese rabodosia, root of Puera...
2015, 33(6): 539-543.
doi: 10.3969/j.issn.1006-0111.2015.06.016
Abstract:
Objective To construct a gene delivery carrier with aptamer-polyethylene glycol-dendrimer-polyamidoamine (APT-PEG-PAMAM), forming nanoparticles to specifically target prostate cancer cell lines, carrying prostate cancer cell proliferative suppressor...
Objective To construct a gene delivery carrier with aptamer-polyethylene glycol-dendrimer-polyamidoamine (APT-PEG-PAMAM), forming nanoparticles to specifically target prostate cancer cell lines, carrying prostate cancer cell proliferative suppressor...
2015, 33(6): 544-546,565.
doi: 10.3969/j.issn.1006-0111.2015.06.017
Abstract:
Objective To explore and analyze the current status of the postgraduate education of clinical pharmacy in China for improving its level and quality. Methods Comprehensive analysis and evaluation were applied for the education models and trends of ...
Objective To explore and analyze the current status of the postgraduate education of clinical pharmacy in China for improving its level and quality. Methods Comprehensive analysis and evaluation were applied for the education models and trends of ...
2015, 33(6): 547-551.
doi: 10.3969/j.issn.1006-0111.2015.06.018
Abstract:
Objective To evaluate the implementation of hospital pharmacy distribution for inpatient pharmacy services, with impact on understanding investigation for ward nurse awareness of the drug storage management, and to optimize ward base drug administra...
Objective To evaluate the implementation of hospital pharmacy distribution for inpatient pharmacy services, with impact on understanding investigation for ward nurse awareness of the drug storage management, and to optimize ward base drug administra...
Establishment and validation of sterility test of levofloxacin lactate and sodium chloride injection
2015, 33(6): 552-554.
doi: 10.3969/j.issn.1006-0111.2015.06.019
Abstract:
Objective To establish a sterility test of levofloxacin lactate and sodium chloride injection. Methods The test was carried out by thin-membrane filtration method with different volume of flushing liquid or adding neutralization into culture mediu...
Objective To establish a sterility test of levofloxacin lactate and sodium chloride injection. Methods The test was carried out by thin-membrane filtration method with different volume of flushing liquid or adding neutralization into culture mediu...
2015, 33(6): 555-556,560.
doi: 10.3969/j.issn.1006-0111.2015.06.020
Abstract:
Objective To develop a method for determination of the rosmarinic acid in Xiaokang capsules. Methods An HPLC method was developed. The determination was performed on Agilent C18 column at 30℃ with a mobile phase composed of methanol: 0.5% formic a...
Objective To develop a method for determination of the rosmarinic acid in Xiaokang capsules. Methods An HPLC method was developed. The determination was performed on Agilent C18 column at 30℃ with a mobile phase composed of methanol: 0.5% formic a...
2015, 33(6): 557-560.
doi: 10.3969/j.issn.1006-0111.2015.06.021
Abstract:
S-1 is the third generation of fluorouracil derivative anti-cancer agent with small side effects, efficacy, and drug delivery is convenient.In a large number of clinical trials and continuous clinical application, it showed the good effect for the tr...
S-1 is the third generation of fluorouracil derivative anti-cancer agent with small side effects, efficacy, and drug delivery is convenient.In a large number of clinical trials and continuous clinical application, it showed the good effect for the tr...
2015, 33(6): 561-565.
doi: 10.3969/j.issn.1006-0111.2015.06.022
Abstract:
Chronic hepatitis B is a worldwide infectious diseases caused by hepatitis B virus (HBV). HBV infection is an important reason for liver cirrhosis and liver cancer in our country. Currently, the interferon and nucleoside analogs antiviral drugs (nucl...
Chronic hepatitis B is a worldwide infectious diseases caused by hepatitis B virus (HBV). HBV infection is an important reason for liver cirrhosis and liver cancer in our country. Currently, the interferon and nucleoside analogs antiviral drugs (nucl...
2015, 33(6): 566-569.
doi: 10.3969/j.issn.1006-0111.2015.06.023
Abstract:
Objective To explore the role of clinical pharmacists in analyzing and dealing with abnormal INR value fluctuations caused by the drug interaction of warfarin and amiodarone in a post heart valve replacement patient. Methods By comparing interacti...
Objective To explore the role of clinical pharmacists in analyzing and dealing with abnormal INR value fluctuations caused by the drug interaction of warfarin and amiodarone in a post heart valve replacement patient. Methods By comparing interacti...
2015, 33(6): 570-572.
doi: 10.3969/j.issn.1006-0111.2015.06.024
Abstract:
Objective To investigate the practices and experience in the organization and implementation process of practical training drill for medical supply support. Methods To review and comment on the overall design ideas, specific steps, practical effec...
Objective To investigate the practices and experience in the organization and implementation process of practical training drill for medical supply support. Methods To review and comment on the overall design ideas, specific steps, practical effec...
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