2015 Vol. 33, No. 4
Display Method:
2015, 33(4): 289-292,327.
doi: 10.3969/j.issn.1006-0111.2015.04.001
Abstract:
Cell co-culture system can better simulate the inner environment of human body, predict drug transport and metabolism in intestinal environment and increase the relation between in vitro cell model and integral animal test. In recent years, co-cultur...
Cell co-culture system can better simulate the inner environment of human body, predict drug transport and metabolism in intestinal environment and increase the relation between in vitro cell model and integral animal test. In recent years, co-cultur...
2015, 33(4): 293-297,346.
doi: 10.3969/j.issn.1006-0111.2015.04.002
Abstract:
Combining the classic pharmacokinetic principles and statistical methods, population pharmacokinetics (PPK) can predict individual pharmacokinetic parameters accurately with sparse data in patients, which may be used for monitoring drug concentration...
Combining the classic pharmacokinetic principles and statistical methods, population pharmacokinetics (PPK) can predict individual pharmacokinetic parameters accurately with sparse data in patients, which may be used for monitoring drug concentration...
2015, 33(4): 298-302.
doi: 10.3969/j.issn.1006-0111.2015.04.003
Abstract:
Tyrosyl-DNA phosphodiesterase Ⅰ (TdpⅠ) is a recently discovered proteinthat catalyzes the hydrolysis of 3'-phosphotyrosyl bonds. Such linkages form in vivo during the interaction of DNA and topoisomerase Ⅰ (TopⅠ). TdpⅠ has been regarded as a potentia...
Tyrosyl-DNA phosphodiesterase Ⅰ (TdpⅠ) is a recently discovered proteinthat catalyzes the hydrolysis of 3'-phosphotyrosyl bonds. Such linkages form in vivo during the interaction of DNA and topoisomerase Ⅰ (TopⅠ). TdpⅠ has been regarded as a potentia...
2015, 33(4): 303-308,379.
doi: 10.3969/j.issn.1006-0111.2015.04.004
Abstract:
DNA topoisomerases (Tops) are essential enzymes that regulate the cellular processes such as replication, transcription, recombination and repair. DNA Tops can be classified into two types, topoisomerase Ⅰ (TopⅠ) and topoisomerase Ⅱ (TopⅡ). They cata...
DNA topoisomerases (Tops) are essential enzymes that regulate the cellular processes such as replication, transcription, recombination and repair. DNA Tops can be classified into two types, topoisomerase Ⅰ (TopⅠ) and topoisomerase Ⅱ (TopⅡ). They cata...
2015, 33(4): 309-312,375.
doi: 10.3969/j.issn.1006-0111.2015.04.005
Abstract:
Nicotinic acetylcholine receptors (nAChRs),also known as neuronal nicotinic receptors,are widely expressed throughout the central and peripheral nervous system. nAChRs play crucial roles in pain signaling. Recently, agonists that target specific nACh...
Nicotinic acetylcholine receptors (nAChRs),also known as neuronal nicotinic receptors,are widely expressed throughout the central and peripheral nervous system. nAChRs play crucial roles in pain signaling. Recently, agonists that target specific nACh...
2015, 33(4): 313-315,323.
doi: 10.3969/j.issn.1006-0111.2015.04.006
Abstract:
Objective To introduce the major pharmacological effects and research progress of benzyltetrahydroisoquinolines alkaloids. Methods The compounds structure, biological activity, mechanism and clinical applications of benzyltetrahydroisoquinolines w...
Objective To introduce the major pharmacological effects and research progress of benzyltetrahydroisoquinolines alkaloids. Methods The compounds structure, biological activity, mechanism and clinical applications of benzyltetrahydroisoquinolines w...
2015, 33(4): 316-318,350.
doi: 10.3969/j.issn.1006-0111.2015.04.007
Abstract:
Objective To study the effect of litchi saponin and flavones on glycometabolism in insulin resistance model of HepG2 cells. Methods Using high insulin in HepG2 cells to establish a cell model of insulin resistance. Cell model was treated by litchi...
Objective To study the effect of litchi saponin and flavones on glycometabolism in insulin resistance model of HepG2 cells. Methods Using high insulin in HepG2 cells to establish a cell model of insulin resistance. Cell model was treated by litchi...
2015, 33(4): 319-323.
doi: 10.3969/j.issn.1006-0111.2015.04.008
Abstract:
Objective To prepare and optimize insulin-loaded N-trimethyl chitosan nanoparticles via orthogonal design, and preliminarily study the effects on blood glucose level. Methods The insulin-loaded N-trimethyl chitosan nanoparticles(INS-NPs) were prep...
Objective To prepare and optimize insulin-loaded N-trimethyl chitosan nanoparticles via orthogonal design, and preliminarily study the effects on blood glucose level. Methods The insulin-loaded N-trimethyl chitosan nanoparticles(INS-NPs) were prep...
2015, 33(4): 324-327.
doi: 10.3969/j.issn.1006-0111.2015.04.009
Abstract:
Objective To study the hypoglycemic activity of semen Trichosanthis oil(STO) and the mechanism on diabetic mice. Methods The alloxan-induced diabetic mice were divided into different groups and given different dose of STO by gavage for 4 weeks, th...
Objective To study the hypoglycemic activity of semen Trichosanthis oil(STO) and the mechanism on diabetic mice. Methods The alloxan-induced diabetic mice were divided into different groups and given different dose of STO by gavage for 4 weeks, th...
2015, 33(4): 328-330,358.
doi: 10.3969/j.issn.1006-0111.2015.04.010
Abstract:
Objective To explore the in vitro fungistasis of nanometer silvers made by different methods on Candida albicans. Methods The minimal inhibitory concentrations (MICs) of Candida albicans strains stimulated to silver nanoparticles were determined b...
Objective To explore the in vitro fungistasis of nanometer silvers made by different methods on Candida albicans. Methods The minimal inhibitory concentrations (MICs) of Candida albicans strains stimulated to silver nanoparticles were determined b...
2015, 33(4): 331-333.
doi: 10.3969/j.issn.1006-0111.2015.04.011
Abstract:
Objective To complete the synthesis of the natural product of crinumaquine. Methods 3,4-methylenedioxyphenethylamine and 2,5-dimthoxyphenylacetic were taken as starting material, and chemical reactions of condensation, cyclization, reduction, oxid...
Objective To complete the synthesis of the natural product of crinumaquine. Methods 3,4-methylenedioxyphenethylamine and 2,5-dimthoxyphenylacetic were taken as starting material, and chemical reactions of condensation, cyclization, reduction, oxid...
2015, 33(4): 334-337.
doi: 10.3969/j.issn.1006-0111.2015.04.012
Abstract:
Objective To build an identification method for Norvascand its counterfeit drugs based on the differences of their pharmaceutical excipients with the original and generic Amlodipine besylatetablets as tools. Methods Raman spectra of pharmaceutical...
Objective To build an identification method for Norvascand its counterfeit drugs based on the differences of their pharmaceutical excipients with the original and generic Amlodipine besylatetablets as tools. Methods Raman spectra of pharmaceutical...
2015, 33(4): 338-340,369.
doi: 10.3969/j.issn.1006-0111.2015.04.013
Abstract:
Objective To optimize the extraction technology of flos Puerariae lobata isoflavone. Methods The flos Puerariae lobata isoflavone was distilled by ethanol circumfluence. Total flavonoids, tectoridin and tectorigenin extracted from Puerariae using ...
Objective To optimize the extraction technology of flos Puerariae lobata isoflavone. Methods The flos Puerariae lobata isoflavone was distilled by ethanol circumfluence. Total flavonoids, tectoridin and tectorigenin extracted from Puerariae using ...
2015, 33(4): 341-346.
doi: 10.3969/j.issn.1006-0111.2015.04.014
Abstract:
Objective To evaluate the effects of sevoflurane on learning and memory of neonatal mice. Methods 122 neonatalmice (7 days postnatal) were included in this study.72 of them were exposed to sevoflurane (1.0 or 0.5MAC,minimum alveolar concentration)...
Objective To evaluate the effects of sevoflurane on learning and memory of neonatal mice. Methods 122 neonatalmice (7 days postnatal) were included in this study.72 of them were exposed to sevoflurane (1.0 or 0.5MAC,minimum alveolar concentration)...
2015, 33(4): 347-350.
doi: 10.3969/j.issn.1006-0111.2015.04.015
Abstract:
Objective To investigate the psychological measurement index for the effectiveness and discrimination of drug packaging (color code) in the medicine for self-aid and mutual-aid. Methods The classical priming paradigm was used to investigate whethe...
Objective To investigate the psychological measurement index for the effectiveness and discrimination of drug packaging (color code) in the medicine for self-aid and mutual-aid. Methods The classical priming paradigm was used to investigate whethe...
2015, 33(4): 351-355.
doi: 10.3969/j.issn.1006-0111.2015.04.016
Abstract:
Objective To compare the co-prescribing patterns of antibacterials between clinic and ER in a tertiary hospital and mine the association rules among drugs in outpatient and emergency prescriptions. Methods The prescribing data of 2009 were sampled...
Objective To compare the co-prescribing patterns of antibacterials between clinic and ER in a tertiary hospital and mine the association rules among drugs in outpatient and emergency prescriptions. Methods The prescribing data of 2009 were sampled...
2015, 33(4): 356-358.
doi: 10.3969/j.issn.1006-0111.2015.04.017
Abstract:
Objective To establish a method for the determination of asiatic acid in the root of Actinidia valvata. Methods HPLC-VWD was used in the analysis. The column was Agilent HC-C18 (4.6 mm×250 mm,5μm);the mobile phase was acetonitrile: (30 mmol/L) ace...
Objective To establish a method for the determination of asiatic acid in the root of Actinidia valvata. Methods HPLC-VWD was used in the analysis. The column was Agilent HC-C18 (4.6 mm×250 mm,5μm);the mobile phase was acetonitrile: (30 mmol/L) ace...
2015, 33(4): 359-362.
doi: 10.3969/j.issn.1006-0111.2015.04.018
Abstract:
Objective To imitate the development process of new drugs with rutin as the model and to do multidisciplinary experiments of preparation and pharmacodynamics of rutin tablets. Methods Thin-layer chromatography was used to identify rutin in Pagodat...
Objective To imitate the development process of new drugs with rutin as the model and to do multidisciplinary experiments of preparation and pharmacodynamics of rutin tablets. Methods Thin-layer chromatography was used to identify rutin in Pagodat...
2015, 33(4): 363-365.
doi: 10.3969/j.issn.1006-0111.2015.04.019
Abstract:
Objective To investigate the clinical features and treatment of liver cirrhosis with hepatitis B complicated by subcutaneous panniculitis-like T-cell lymphoma (SPTCL) associated hemophagocytic syndrome (HPS). Methods A retrospective analysis of ca...
Objective To investigate the clinical features and treatment of liver cirrhosis with hepatitis B complicated by subcutaneous panniculitis-like T-cell lymphoma (SPTCL) associated hemophagocytic syndrome (HPS). Methods A retrospective analysis of ca...
2015, 33(4): 366-369.
doi: 10.3969/j.issn.1006-0111.2015.04.020
Abstract:
Objective To explore the method of clinical pharmacists participating in designing therapy regimens and carrying out pharmaceutical care. Methods The clinical pharmacists participated in antiinfective therapy of one patient through learning litera...
Objective To explore the method of clinical pharmacists participating in designing therapy regimens and carrying out pharmaceutical care. Methods The clinical pharmacists participated in antiinfective therapy of one patient through learning litera...
2015, 33(4): 370-372.
doi: 10.3969/j.issn.1006-0111.2015.04.021
Abstract:
Objective To investigate risk factors for Pseudomonas aeruginosa infected AECOPD patients and the significance of immune regulation. Methods The clinical pharmacist is involved in the administration and guardianship of immunocompromised patients w...
Objective To investigate risk factors for Pseudomonas aeruginosa infected AECOPD patients and the significance of immune regulation. Methods The clinical pharmacist is involved in the administration and guardianship of immunocompromised patients w...
2015, 33(4): 373-375.
doi: 10.3969/j.issn.1006-0111.2015.04.022
Abstract:
Olaparib is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, and was developed by AstraZeneca Pharmaceuticals LP. Olaparib has therapeutic potential for treating cancers associated with impaired DNA repair capabilities, particularly those...
Olaparib is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, and was developed by AstraZeneca Pharmaceuticals LP. Olaparib has therapeutic potential for treating cancers associated with impaired DNA repair capabilities, particularly those...
Investigation and analysis on off-label use of antibacterials for outpatients and emergency patients
2015, 33(4): 376-379.
doi: 10.3969/j.issn.1006-0111.2015.04.023
Abstract:
Objective To investigate the off-label use of antibacterials in out-patient department and emergency departmentand give reference for management. Methods About 10% of antibacterials prescriptions in out-patient department and emergency department ...
Objective To investigate the off-label use of antibacterials in out-patient department and emergency departmentand give reference for management. Methods About 10% of antibacterials prescriptions in out-patient department and emergency department ...
2015, 33(4): 380-382,384.
doi: 10.3969/j.issn.1006-0111.2015.04.024
Abstract:
Objective To assess the effects of compound glycyrrhizin tablets for chronic eczema patients using the Meta-analysis method. Methods The national literatures related to random control clinical trials on compound glycyrrhizin tablets for treating c...
Objective To assess the effects of compound glycyrrhizin tablets for chronic eczema patients using the Meta-analysis method. Methods The national literatures related to random control clinical trials on compound glycyrrhizin tablets for treating c...
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