2015 Vol. 33, No. 2
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2015, 33(2): 97-101,130.
doi: 10.3969/j.issn.1006-0111.2015.02.001
Abstract:
Research progress of flavanone compounds synthesis was reviewed, various types of synthesis methods of flavanone compounds were summarized, and methodological support for flavanone compounds in new drug research and development was provided. Research...
Research progress of flavanone compounds synthesis was reviewed, various types of synthesis methods of flavanone compounds were summarized, and methodological support for flavanone compounds in new drug research and development was provided. Research...
2015, 33(2): 102-105,137.
doi: 10.3969/j.issn.1006-0111.2015.02.002
Abstract:
Changium smyrnioides (C. smyrnioides) Wolff is one species of monotypic genus in the Apiaceae family which is a Chinese endemic species medicinal plant. It has the effect of nourishing the body, improving health, moistening the lung, eliminating sput...
Changium smyrnioides (C. smyrnioides) Wolff is one species of monotypic genus in the Apiaceae family which is a Chinese endemic species medicinal plant. It has the effect of nourishing the body, improving health, moistening the lung, eliminating sput...
2015, 33(2): 106-109,170.
doi: 10.3969/j.issn.1006-0111.2015.02.003
Abstract:
Objective To analyze the current problems on tumor-targeting nanoparticle drug delivery system. Methods Recent researches of tumor-targeting nanoparticle drug delivery system were collected, read and summarized. Results Three research fields on ...
Objective To analyze the current problems on tumor-targeting nanoparticle drug delivery system. Methods Recent researches of tumor-targeting nanoparticle drug delivery system were collected, read and summarized. Results Three research fields on ...
2015, 33(2): 110-113.
doi: 10.3969/j.issn.1006-0111.2015.02.004
Abstract:
Tripterygium wilfordii has been widely used in clinic for the treatment of autoimmune diseases, such as nephrotic syndrome, rheumatoid arthritis, systemic lupus erythematosus, and the curative effect is significant. But it has toxic and side effects ...
Tripterygium wilfordii has been widely used in clinic for the treatment of autoimmune diseases, such as nephrotic syndrome, rheumatoid arthritis, systemic lupus erythematosus, and the curative effect is significant. But it has toxic and side effects ...
2015, 33(2): 114-118.
doi: 10.3969/j.issn.1006-0111.2015.02.005
Abstract:
Objective To prepare oxidized mesoporous carbon nanospheres and investigate potential application as drug delivery carriers for paclitaxel. Methods Physicochemical properties such as morphology, diameter, pore diameter and pore volume were charact...
Objective To prepare oxidized mesoporous carbon nanospheres and investigate potential application as drug delivery carriers for paclitaxel. Methods Physicochemical properties such as morphology, diameter, pore diameter and pore volume were charact...
2015, 33(2): 119-121,175.
doi: 10.3969/j.issn.1006-0111.2015.02.006
Abstract:
Objective To establish HPLC method to detect docetaxel and compare the stability of a novel polyethylene glycol mediated lipid nanoemulsion of docetaxel with docetaxel injection saline dilutions. Methods HPLC method was established to detect docet...
Objective To establish HPLC method to detect docetaxel and compare the stability of a novel polyethylene glycol mediated lipid nanoemulsion of docetaxel with docetaxel injection saline dilutions. Methods HPLC method was established to detect docet...
2015, 33(2): 122-124.
doi: 10.3969/j.issn.1006-0111.2015.02.007
Abstract:
Objective To optimize the synthesis of photosensitizer chlorine e6-C15 monomethyl ester (1). Methods Target compound 1 was synthesized through E ring cracking of pheophorbide a (3) in methanol solution of potassium hydroxide followed by adding H2O...
Objective To optimize the synthesis of photosensitizer chlorine e6-C15 monomethyl ester (1). Methods Target compound 1 was synthesized through E ring cracking of pheophorbide a (3) in methanol solution of potassium hydroxide followed by adding H2O...
2015, 33(2): 125-126,178.
doi: 10.3969/j.issn.1006-0111.2015.02.008
Abstract:
Objective To study the hemostasis activity of iodine complex with carboxymethyl chitosan. Methods The polymers were prepared with azodiisobutyronitrile as the initiating agent and sodium acrylate, N-vinylpyrrolidone, carboxymethyl chitosan and N,N...
Objective To study the hemostasis activity of iodine complex with carboxymethyl chitosan. Methods The polymers were prepared with azodiisobutyronitrile as the initiating agent and sodium acrylate, N-vinylpyrrolidone, carboxymethyl chitosan and N,N...
2015, 33(2): 127-130.
doi: 10.3969/j.issn.1006-0111.2015.02.009
Abstract:
Objective To improve the synthetic condition of 6-methoxyisatin. Methods The starting material 3-methoxyaniline was firstly converted into the intermediate 1-oximino-N- (3-methoxyphenyl) acetamide through Sandmeyer reaction, then 6-methoxyisatin w...
Objective To improve the synthetic condition of 6-methoxyisatin. Methods The starting material 3-methoxyaniline was firstly converted into the intermediate 1-oximino-N- (3-methoxyphenyl) acetamide through Sandmeyer reaction, then 6-methoxyisatin w...
2015, 33(2): 131-133,142.
doi: 10.3969/j.issn.1006-0111.2015.02.010
Abstract:
Objective To compose and evaluate anti-tumor activities of 3-substituted indole-2-one compounds which may have dual inhibitory activities against both tubulin protein and VEGFR-2 tyrosine kinase. Methods Target compounds were prepared starting fro...
Objective To compose and evaluate anti-tumor activities of 3-substituted indole-2-one compounds which may have dual inhibitory activities against both tubulin protein and VEGFR-2 tyrosine kinase. Methods Target compounds were prepared starting fro...
2015, 33(2): 134-137.
doi: 10.3969/j.issn.1006-0111.2015.02.011
Abstract:
Objective To optimize the extraction technology of total falvonoids from Hypericum sampsonii. Methods On the basis of single factor test, solid-liquid ratio, ethanol concentration, extraction time, extraction temperature and extraction times on th...
Objective To optimize the extraction technology of total falvonoids from Hypericum sampsonii. Methods On the basis of single factor test, solid-liquid ratio, ethanol concentration, extraction time, extraction temperature and extraction times on th...
2015, 33(2): 138-142.
doi: 10.3969/j.issn.1006-0111.2015.02.012
Abstract:
Objective To investigate the synergic ratio of sorafenib (SO) and sulforaphane (SF) against the hepatocellular carcinoma cell line HepG2 in vitro. Methods The synergic effect of SO combined with SF against HepG2 cells was determined by the CCK8 as...
Objective To investigate the synergic ratio of sorafenib (SO) and sulforaphane (SF) against the hepatocellular carcinoma cell line HepG2 in vitro. Methods The synergic effect of SO combined with SF against HepG2 cells was determined by the CCK8 as...
2015, 33(2): 143-146,158.
doi: 10.3969/j.issn.1006-0111.2015.02.013
Abstract:
Objective To develop an SPE-HPLC method for the determination of methotrexate (MTX) in human plasma to monitor the clinical drug use of MTX, and to identify the human metabolite of MTX by mass spectrometry. Methods MTX was extracted from human pla...
Objective To develop an SPE-HPLC method for the determination of methotrexate (MTX) in human plasma to monitor the clinical drug use of MTX, and to identify the human metabolite of MTX by mass spectrometry. Methods MTX was extracted from human pla...
2015, 33(2): 147-149,170.
doi: 10.3969/j.issn.1006-0111.2015.02.014
Abstract:
Objective To study the anti-microbial activity and strength of allicin on Campylobacter jejuni. Methods Disc diffusion method (K-B) was used to determine the diameter of the bacteriostatic ring. The minimal inhibitory concentration (MIC) of allici...
Objective To study the anti-microbial activity and strength of allicin on Campylobacter jejuni. Methods Disc diffusion method (K-B) was used to determine the diameter of the bacteriostatic ring. The minimal inhibitory concentration (MIC) of allici...
2015, 33(2): 150-152,155.
doi: 10.3969/j.issn.1006-0111.2015.02.015
Abstract:
Objective To evaluate the workload of dispensing department in hospital using multivariate subdivision post scoring method. Methods Workload data of dispensing department in hospital were collected through scoring the workload of dispensing depart...
Objective To evaluate the workload of dispensing department in hospital using multivariate subdivision post scoring method. Methods Workload data of dispensing department in hospital were collected through scoring the workload of dispensing depart...
2015, 33(2): 153-155.
doi: 10.3969/j.issn.1006-0111.2015.02.016
Abstract:
Objective To develop a stable method for fingerprint analysis of extractum platycodi liquidum to ensure its uniformity and stability. Methods UPLC-ELSD was applied to obtain a chromatogram with 11 well separated peaks, and the chromatographic cond...
Objective To develop a stable method for fingerprint analysis of extractum platycodi liquidum to ensure its uniformity and stability. Methods UPLC-ELSD was applied to obtain a chromatogram with 11 well separated peaks, and the chromatographic cond...
2015, 33(2): 156-158.
doi: 10.3969/j.issn.1006-0111.2015.02.017
Abstract:
Objective To establish a method for determination of the content of Forsythoside A in Yinqiaosan granules. Methods HPLC method was adopted to carry on the determination. Welch Ultimate XB-C18 column (250 mm×4.6 mm,5 μm) was used with the mobile ph...
Objective To establish a method for determination of the content of Forsythoside A in Yinqiaosan granules. Methods HPLC method was adopted to carry on the determination. Welch Ultimate XB-C18 column (250 mm×4.6 mm,5 μm) was used with the mobile ph...
2015, 33(2): 159-162,192.
doi: 10.3969/j.issn.1006-0111.2015.02.018
Abstract:
Objective To study the relationship between circulating tumor cells(CTCs) in peripheral blood of the patients with hepatocellular carcinoma (HCC) and its metastasis and prognosis. Methods 35 patients with hepatocellular carcinoma were collected as...
Objective To study the relationship between circulating tumor cells(CTCs) in peripheral blood of the patients with hepatocellular carcinoma (HCC) and its metastasis and prognosis. Methods 35 patients with hepatocellular carcinoma were collected as...
2015, 33(2): 163-166,182.
doi: 10.3969/j.issn.1006-0111.2015.02.019
Abstract:
Cancer-induced immunosuppressive cells play an important immunosuppressive role during the tumor development process, and the development and progression of tumors are always accompanied with abnormal accumulation of cancer-induced immunosuppressive ...
Cancer-induced immunosuppressive cells play an important immunosuppressive role during the tumor development process, and the development and progression of tumors are always accompanied with abnormal accumulation of cancer-induced immunosuppressive ...
2015, 33(2): 167-170.
doi: 10.3969/j.issn.1006-0111.2015.02.020
Abstract:
Objective To explore the working pattern for endocrinology clinical pharmacists participating in clinical drug treatment. Methods By participating in the treatment for a patient with diabetes and hyperprolactinemia and analyzing the causes of poor...
Objective To explore the working pattern for endocrinology clinical pharmacists participating in clinical drug treatment. Methods By participating in the treatment for a patient with diabetes and hyperprolactinemia and analyzing the causes of poor...
2015, 33(2): 171-172.
doi: 10.3969/j.issn.1006-0111.2015.02.021
Abstract:
Objective To observe the curative effect of magnesium isoglycyrrhizinate in prevention of liver injury induced by oxaliplatin. Methods The control group used oxaliplatin, leucovorin, 5-fluorouracil chemotherapy, the treatment group were treated wi...
Objective To observe the curative effect of magnesium isoglycyrrhizinate in prevention of liver injury induced by oxaliplatin. Methods The control group used oxaliplatin, leucovorin, 5-fluorouracil chemotherapy, the treatment group were treated wi...
2015, 33(2): 173-175.
doi: 10.3969/j.issn.1006-0111.2015.02.022
Abstract:
Objective To compare the therapeutic effectiveness and safeness of venlafaxine sustained-release capsules and citalopram tablets in the treatment of post-stroke depression. Methods 60 patients were randomly divided into venlafaxine group (n=30)and...
Objective To compare the therapeutic effectiveness and safeness of venlafaxine sustained-release capsules and citalopram tablets in the treatment of post-stroke depression. Methods 60 patients were randomly divided into venlafaxine group (n=30)and...
2015, 33(2): 176-178.
doi: 10.3969/j.issn.1006-0111.2015.02.023
Abstract:
Objective To achieve outpatient prescriptions audit before payment and dispensing, optimize the dispensing process,improve the ratio of qualified prescriptions and promote rational use of drugs. Methods Based on the Hospital Information System (HI...
Objective To achieve outpatient prescriptions audit before payment and dispensing, optimize the dispensing process,improve the ratio of qualified prescriptions and promote rational use of drugs. Methods Based on the Hospital Information System (HI...
2015, 33(2): 179-182.
doi: 10.3969/j.issn.1006-0111.2015.02.024
Abstract:
Objective To analyze the reason of drug shortages in medical institutions and take corresponding prevention measures to ensure drug supply. Methods The drug outbound orders in 2012 were retrospectively analyzed to trace the procurement plan of bad...
Objective To analyze the reason of drug shortages in medical institutions and take corresponding prevention measures to ensure drug supply. Methods The drug outbound orders in 2012 were retrospectively analyzed to trace the procurement plan of bad...
2015, 33(2): 183-186.
doi: 10.3969/j.issn.1006-0111.2015.02.025
Abstract:
Objective To provide suggestion and reference for standardizing irregular usage of drug prescription in hospital. Methods Prescriptions of outpatient section and emergency room in Heshan People's Hospital were extracted from January to June 2013. ...
Objective To provide suggestion and reference for standardizing irregular usage of drug prescription in hospital. Methods Prescriptions of outpatient section and emergency room in Heshan People's Hospital were extracted from January to June 2013. ...
2015, 33(2): 187-189.
doi: 10.3969/j.issn.1006-0111.2015.02.026
Abstract:
Objective To investigate the effect of quality control circle in the reduction of medicine waiting time for out-patients. Methods Analyze the reason of the increase of medicine waiting time for out-patients was analyzed. Specific plan was made and...
Objective To investigate the effect of quality control circle in the reduction of medicine waiting time for out-patients. Methods Analyze the reason of the increase of medicine waiting time for out-patients was analyzed. Specific plan was made and...
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