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2014 Vol. 32, No. 2

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Signaling pathway of acetylcholine receptors in atherosclerosis induced by nicotinic
LIU Dianhua, ZHANG Enhui, LIU Chong, FAN Boshi, CAI Guojun
2014, 32(2): 81-84. doi: 10.3969/j.issn.1006-0111.2014.02.001
Abstract:
Objective Atherosclerosis is an inflammatory disease in the vessel wall. Nicotine, a major component of cigarette smoke, is an independent risk factor for cardiovascular diseases including atherosclerosis. Recent studies have shown that nicotine (th...
In vitro evaluation of lipid drug delivery system by lipolysis model
ZENG Qiping, ZHANG Jing, LIU Zhihong, SONG Hongtao
2014, 32(2): 85-87. doi: 10.3969/j.issn.1006-0111.2014.02.002
Abstract(3087) PDF (417KB)(256)
Abstract:
Objective To review the composition of lipolysis model and the application in the in vitro evaluation of lipid formulations, provide reference for promoting the development of lipid formulations. Methods Recent relevant literatures were analyzed a...
Pharmacokinetics of compound formula of traditional Chinese medicine
HUANG Huimei, LIU Runhui
2014, 32(2): 88-91. doi: 10.3969/j.issn.1006-0111.2014.02.003
Abstract:
Based on the related literature study on the pharmacokinetic research on compound prescriptions of traditional Chinese medicine (TCM),common methods of research as well as some constantly emerging new theories and new methods were summarized, researc...
Application progress in quantitative NMR in analysis of traditional Chinese medicine
LIN Shan, SU Juan, YE Ji, CAO Bangjing, ZHANG Weidong
2014, 32(2): 92-95,106. doi: 10.3969/j.issn.1006-0111.2014.02.004
Abstract(3993) PDF (614KB)(257)
Abstract:
Objective To review the principle of qNMR and applications progress in traditional Chinese medicine (TCM) analysis in recent ten years. Methods Literatures in recent ten years which concerning the application of qNMR technology in TCM analysis wer...
Role of apoptosis in radiation-induced tissue damage
YANG Hong, NI Min, ZHAO Xinbin, TAO Xia
2014, 32(2): 96-97,149. doi: 10.3969/j.issn.1006-0111.2014.02.005
Abstract:
Ionizing radiation is able to induce tissue damage, which is related to cell apoptosis, necrosis and inflammation, etc. The signaling pathway underlying radiation-induced apoptosis remains unclear. However, it's well-accepted that several targets wer...
Design, synthesis and anti-tumor activities of 2-(4-trifluoromethylphenyl)-4-ethyl-furan-3-amide derivatives
ZHANG Tao, WANG Tiantian, ZHANG Yikai, NIU Chunjuan, LI Lingzhen, LI Ke
2014, 32(2): 98-101,120. doi: 10.3969/j.issn.1006-0111.2014.02.006
Abstract:
Objective To study the designing,synthesis and anti-tumor activities of the novel 2-(4-trifluoromethylphenyl)-4-ethyl-furan-3-amide derivatives. Methods 4-(trifluoromethyl)benzaldehyde and diethyl malonate were used as the starting materials to sy...
Synthesis and anti-platelet aggregative activity of novel 2, 5-dihydrofuran derivatives
ZHONG Hanyu, ZHANG Yikai, ZHANG Jingyi, LI Ke
2014, 32(2): 102-106. doi: 10.3969/j.issn.1006-0111.2014.02.007
Abstract:
Objective To study the synthesis and anti-platelet aggregative activity of 2-(4-methoxyphenyl)-4-vinyl-2,5-dihydrofuran-3-carboxylic acid derivatives. Methods 17 target compounds were designed, synthesized and determined via 1H-NMR spectra and MS. ...
Synthesis and platelet aggregation inhibition activity of new derivatives of pyridazinone
SONG Yan, CANG Jie, MENG Lei, MA Fujia
2014, 32(2): 107-109,123. doi: 10.3969/j.issn.1006-0111.2014.02.008
Abstract:
Objective To study the antiplatelet aggregative activity of 6-(4-substitued acetamino-phenyl 4,5-dihydro-3(2H)-pyridazinones with different amino group. Methods Nine target compounds were designed and synthesized.All of them were confirmed by 1H-N...
Alleviation of reperfusion injury for liver graft via inhibiting inflammatory response by ulinastatin
LIN Feng, ZHOU Zhijun, ZHANG Chenhong, LIU Fang, GUO Wenyuan, WEI Ruohan, CHEN Hui
2014, 32(2): 110-113,127. doi: 10.3969/j.issn.1006-0111.2014.02.009
Abstract:
Objective To evaluate the protective effect of ulinastatin on reperfusion injury of liver graft in rats and the related mechanisms. Methods The orthotopic liver transplantation (OLT) model between syngeneic Sprague-Dawley rats was used, and recipi...
Investigation on the influence-factor of preparation of ethyl cellulose ethoce matrix sustained-release tablets for water-soluble drug
WANG Xiuli, DANG Xiaofang, LIAO Yan, ZHAO Baosheng
2014, 32(2): 114-117,146. doi: 10.3969/j.issn.1006-0111.2014.02.010
Abstract:
Objective To systematically investigate the factors of preparation of ethyl cellulose ethoce matrix sustained-release tablets for water-soluble drug. Methods Cordilox was taken as a water-soluble model drug, accumulative release rate was taken as ...
Efficacy observation of defibrase combined standard regimen in treatment of non ST segment elevation myocardial infarction
ZHAO Rang, LIU Xin
2014, 32(2): 118-120. doi: 10.3969/j.issn.1006-0111.2014.02.011
Abstract:
Objective To discuss the effectiveness of defibrase in the treatment of NSTEMI and effects of defibrase on the prognosis of NSTEMI. Methods 86 patients with NSTEMI were randomly divided into treatment group and control group, patients received sta...
Determination of gardenoside and paeoniflorin in Ankun granule by HPLC
ZHANG Liping
2014, 32(2): 121-123. doi: 10.3969/j.issn.1006-0111.2014.02.012
Abstract:
Objective To establish the HPLC method for the determination of gardenoside and paeoniflorin in Ankun granule. Methods The column was Agilent Eclipse XDB C18 (250 mm×4.6 mm,5 μm),and the acetonitrile-water(14:86) was used as the mobile phase.The d...
The influence of rhGM-CSF gel to curing the CIN wound healing
ZHENG Jie, ZHU Zhenzhen, YU Rufen
2014, 32(2): 124-127. doi: 10.3969/j.issn.1006-0111.2014.02.013
Abstract:
Objective To study the influence of external recombinant human granulocyte/macrophage colony-stimulating factor (rhGM-CSF) gel on wound healing after LEEP for curing the CIN. Methods 124 patients with CIN were selected and divided into two groups:t...
Pharmaceutical care on a lung cancer patient with aggressive pulmonary fungus infection
HOU Xingyun, JIAO Yang, CAI Heping, Wang Zhuo
2014, 32(2): 128-130. doi: 10.3969/j.issn.1006-0111.2014.02.014
Abstract(3269) PDF (401KB)(291)
Abstract:
Objective To explore the method of pharmaceutical care by the pharmaceutical care and drug analysis of a case of lung cancer patient with aggressive pulmonary fungus infection. Methods Whole pharmacy care was given by clinical pharmacists to the pa...
Cases analysis on clinical non-standard use of drug injection
LIU Weihai, LIU Yun
2014, 32(2): 131-134. doi: 10.3969/j.issn.1006-0111.2014.02.015
Abstract:
Objective To analyze the clinical drug injection use cases, find concerns of use, standardize clinical use of injection drugs, reduce drug irrational use of medical practices, ensure safety and effectiveness on the use of drugs. Methods 18 specific...
The effect of sufentanil on the minimum local analgesic concentration of epidural lidocaine
XIE Fanghua, SONG Shaobo, ZHANG Jian
2014, 32(2): 135-137. doi: 10.3969/j.issn.1006-0111.2014.02.016
Abstract:
Objective To compare the effect of different dosage of sulfentanil on the minimum local analgesic concentration of epidural licocaine. Methods 90 patients with urology and anorectic surgery, ASA Ⅰ or Ⅱ, 32-63 years, were randomly divided into 3 gro...
A cross-sectional survey of therapeutic drugs for inpatient mental disease
CHENG Xiaolin, XIAO Lin
2014, 32(2): 138-140,143. doi: 10.3969/j.issn.1006-0111.2014.02.017
Abstract:
Objective To study the clinical application of psychotropic agents for psychiatric patients in our hospital and provide the basis for promoting rational clinical usage of drugs. Methods A cross-sectional survey method was used to survey the neurol...
Analysis of utilization of narcotic drugs in Central Hospital of Shanghai Yangpu District from 2010 to 2012
HUANG Xiongwei, GAO Jinghua, GAO Chunhong
2014, 32(2): 141-143. doi: 10.3969/j.issn.1006-0111.2014.02.018
Abstract(3109) PDF (383KB)(107)
Abstract:
Objective To evaluate the rationality of narcotic drugs used in Central Hospital of Shanghai Yangpu District and provide reference for clinical rational drug use by analyzing the situation of narcotic drugs used in the hospital. Methods The total c...
Evaluation the control measurement of high-risk drugs in the hospital
SUN Tingting, HU Zhongjie, ZHANG Sishi, ZHANG Yan
2014, 32(2): 144-146. doi: 10.3969/j.issn.1006-0111.2014.02.019
Abstract(2970) PDF (378KB)(192)
Abstract:
Objective To evaluate the measurements for high-risk drugs and ensure the safety of clinical use. Methods Hospital medical staffs were surveyed on high-risk drug knowledge and the management of high-risk drugs of each departments was checked, the p...
Effectiveness of rectification antimicrobial agent prescriptions in outpatient and emergency department
XU Wenyu, XIAO Xingfeng, CHEN Meili, ZHANG Lin, DING Jiewei
2014, 32(2): 147-149. doi: 10.3969/j.issn.1006-0111.2014.02.020
Abstract:
Objective To analyze effectiveness of rectification antimicrobial agent prescriptions in outpatient and emergency department in Shaoxing People's Hospital. Methods To analyze antimicrobial agent prescriptions rate, antimicrobial agent prescription...
Effect evaluation of practice of quality control circle activity in hospital pharmacy
YU Youna
2014, 32(2): 150-152. doi: 10.3969/j.issn.1006-0111.2014.02.021
Abstract:
Objective To reduce the number of medication error in outpatient pharmacy for western medicine and to improve the quality of work in pharmacy department. Methods The quality control circle(QCC) activity was applied in the quality management of pres...
Exploration of teaching reform in pharmacological experiment for pharmaceutical specialties
YU Jianguang, CHENG Minghe, MIAO Chaoyu, SU Dingfeng
2014, 32(2): 153-155. doi: 10.3969/j.issn.1006-0111.2014.02.022
Abstract:
Objective To summarize the practices of teaching reform in pharmacological experiment for pharmaceutical specialties and gather experiences for improving teaching quality. Methods Reforms were performed in construction of curriculum and conditions...
Exploration and practice the new mode of supervisor directed system in the practical teaching for pharmaceutical major
PENG Shengming, DING Yonglan, YANG Chunguang, WU Ping
2014, 32(2): 156-157. doi: 10.3969/j.issn.1006-0111.2014.02.023
Abstract:
Practical teaching played an essential role in the student training of pharmaceutical major. However, the current practical teaching mode was difficult to achieve the goal of student training. A new teaching mode named supervisor directed system (SDS...
Thinking of post-graduate students education in the major of pharmacy in military university
DING Li, FAN Li, LIN Zhiyong
2014, 32(2): 158-159. doi: 10.3969/j.issn.1006-0111.2014.02.024
Abstract:
Objective Basic research oriented post-graduate education could not accommodate with the pluralistic society nowadays. The dilemma of post-graduate education from several parts was reviewed in this article, such as employment obtaining, evaluation i...
2014, 32(2): 160-160.
Abstract: