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2014 Vol. 32, No. 3

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Progress in pathophysiology and related drug development of hypoxia-inducible factor-1
FENG Shijie, MA Xiujuan, ZONG Ying, MAO Yu, ZHANG Xiaodong, GONG Xuelian, ZHANG Xiaofang, LU Guocai
2014, 32(3): 161-166. doi: 10.3969/j.issn.1006-0111.2014.03.001
Abstract:
Hypoxia-inducible factor-1 (HIF-1) is a critical nuclear transcriptional factor mediating cell adaptive response to hypoxia in mammalian and human. It is the key mediator which modulates oxygen homeostasis exclusively. In the one hand, HIF-1 can prot...
History and processing research on herbal juice
CUI Ni, SHI Ji, JING Haiyi, JIA Tianzhu
2014, 32(3): 167-170,198. doi: 10.3969/j.issn.1006-0111.2014.03.002
Abstract(3461) PDF (753KB)(436)
Abstract:
The literatures of classic and modern application of herbal juice, like ginger juice, licorice juice, rice water, evodia rutaecarpa juice, black soya bean juice, bile, etc were collected. The history and successive changes of the processing research ...
Research progress in structural modification and pharmacological activities of berberine
JIN Xin, SONG Xia, CAO Yongbin, JIANG Yuanying, SUN Qingyan
2014, 32(3): 171-175. doi: 10.3969/j.issn.1006-0111.2014.03.003
Abstract(5695) PDF (689KB)(551)
Abstract:
Berberine was an isoquinoline type alkaloid extracted from Chinese herbs such as Coptis chinensis. Recently, as a great many berberine derivatives had been synthesized with comprehensive physiological functions, the structural modification and applic...
Research progress in steroid hormone analysis in vivo by chromatography-mass spectrometry
QIAN Xian, ZHAO Liang, LU Lei, ZHANG Hai, LI Yueyue, ZHANG Guoqing
2014, 32(3): 176-180,190. doi: 10.3969/j.issn.1006-0111.2014.03.004
Abstract(4364) PDF (789KB)(341)
Abstract:
Steroid hormones were chemical compounds of high efficiency, which played a significant role in various physiological activities. However, the concentrations of hormones in vivo were extremely low, so it was very important for their accurate quantifi...
Overview of the research on drug impurity
LI Na, LOU Ziyang
2014, 32(3): 179-185. doi: 10.3969/j.issn.1006-0111.2014.03.005
Abstract(3556) PDF (620KB)(183)
Abstract:
As special commodities, drugs had closely relationships with human beings' health and life safety. Impurity, which would influence the stability and efficacy of drugs, was closely related to the quality, safety and efficacy of drugs. With more and mo...
Synthesis and antifungal activities of novel triazole derivatives
WU Maocheng, LI Xiang, WU Qiuye
2014, 32(3): 186-190. doi: 10.3969/j.issn.1006-0111.2014.03.006
Abstract:
Objective To synthesize a new series of triazole compounds with naphthalene benzyl as side chain and evaluate the antifungal activity. Methods Nine title compounds were synthesized and determined by the 1H NMR and MS spectra. According to the metho...
Synthesis,XRD analysis and anti-tumor activity of novel compounds containing tetrahydronaphthalen-2-ol
SUN Nannan, LIU Jia, ZHENG Canhui, ZHOU Youjun
2014, 32(3): 191-194. doi: 10.3969/j.issn.1006-0111.2014.03.007
Abstract(3414) PDF (422KB)(301)
Abstract:
Objective To synthesize the enantiomers of (E)-6-methoxy-1-(3,4,5-trimethoxybenzylidene)-1,2,3,4-tetrahydronaphthalen-2-ol,determine their structures by XRD and evaluate their anti-tumor activity in vitro. Methods The target compounds were prepared...
Screening the best ratio of artesunate and ursolic acid for lipid-lowering
YE Yalin, WANG Yuliang, WANG Zejian, YIN Ming, XIN Hailiang, ZHANG Lei
2014, 32(3): 195-198. doi: 10.3969/j.issn.1006-0111.2014.03.008
Abstract:
Objective To observe the effect of different doses unilateral and compound of artesunate and ursolic acid on lipid metabolism in rats' model, find out the best ratio of artesunate and ursolic acid. Methods Lipid metabolism disorders model was induc...
Inactivation and validation of virus in blood products of human coagulation factor Ⅷ
YAN Chen, XIONG Keqiang, WANG Wenji, LI Ling
2014, 32(3): 199-202. doi: 10.3969/j.issn.1006-0111.2014.03.009
Abstract(3361) PDF (433KB)(361)
Abstract:
Objective To study effect of virus inactivation/removal treated by solvent/detergent method and dry heating at 80℃, 72 h for inactivation in human coagulation factor Ⅷ. Methods Human coagulation factor Ⅷ extracted from healthy human plasma were tre...
Study on drug resistance of Acinetobacter baumannii before and after special anti-bacterial drugs remediation
XU Nongzhang, JIN Zhonghua, WANG Zhijing
2014, 32(3): 203-205. doi: 10.3969/j.issn.1006-0111.2014.03.010
Abstract:
Objective To investigate the drug resistance of Acinetobacter baumannii and antibiotics use density of all kinds of antibacterial drugs before and after special antibacterial drugs remediation, provide evidence for the follow-up intervention strateg...
Detection of glinides adulterated in traditional Chinese medicine for diabetes by TLC-SERS
QIN Jianhong
2014, 32(3): 206-208,230. doi: 10.3969/j.issn.1006-0111.2014.03.011
Abstract:
Objective To establish detection method of glinides adulterated illegally in hypoglycemic traditional Chinese medicine (TCM) by surface enhanced Raman spectroscopy (SERS). Methods Adulterated chemicals and TCM matrixes were separated by TLC first. ...
Screening of main active components against cardiomyocyte hypoxia/reoxygenation injury in shexiang baoxin Pill
HAN Lin, LV Chao, LI Min, HUANG Huimei, CHANG Wanlin, PENG Chengcheng, LIU Runhui
2014, 32(3): 209-211,219. doi: 10.3969/j.issn.1006-0111.2014.03.012
Abstract:
Objective To build hypoxia/reoxygenation injury model in cultured neonatal rat cardiomyocyte and screen active components from Shexiang Baoxin Pill (SBP) absorbed in blood against hypoxia/reoxygenation injury. Methods Cardiomyocytes were isolated a...
Preclinical pharmacodynamic research of Juhuang Qingre San
MI Li, CHEN Wansheng, LI Jingchao, WU Guangtong
2014, 32(3): 212-215,234. doi: 10.3969/j.issn.1006-0111.2014.03.013
Abstract:
Objective To investigate the efficacy on antibacterial, antipyretic, analgesic, anti-inflammatory and immune regulation of Juhuang Qingre San. Methods Efficacy on antibacterial was evaluated by the method of doubling dilution,vivo antibacterial eff...
Investigation of the vancomycin trough concentration in elderly patients with severe infection
CHEN Shumin, TIAN Wenyuan, BIAN Meng, ZHANG Jie
2014, 32(3): 216-219. doi: 10.3969/j.issn.1006-0111.2014.03.014
Abstract:
Objective To investigate the vancomycin trough concentration in elderly patients with severe infection and provide references for clinical use of drugs effectively. Methods According to the Ccr of elderly patients(56 cases), who were≥65 years old, ...
The effect of vitamin B on the treatment of senile vaginitis
WEI Ruohan, ZHANG Chenhong, YANG Xinyu
2014, 32(3): 220-221,224. doi: 10.3969/j.issn.1006-0111.2014.03.015
Abstract:
Objective To explore the effect of vitamin B on the treatment of senile vaginitis. Methods A total of 124 patients suffered senile vaginitis were included in the study, who were accepted the treatment of compound metronidazole suppositories and est...
Clinic research on Saccharomyces boulardii in preventing and treating antibiotics associated diarrhea in infant pneumonia
LI Jiming, ZHANG Huifen, XIE Hui, SHEN Tong
2014, 32(3): 222-224. doi: 10.3969/j.issn.1006-0111.2014.03.016
Abstract:
Objective To investigate the therapeutic effect of Saccharomyces boulardii on antibiotics associated diarrhea(AAD)in infant pneumonia. Methods 302 hospitalized infant patients (1 month-3 years) with pneumonia but without gastroenteric disease were ...
Pharmaceutical care under health management model
FU Xiang, WANG Boran, WANG Fuli, CHEN Shengxin
2014, 32(3): 225-227. doi: 10.3969/j.issn.1006-0111.2014.03.017
Abstract:
To compare the concepts of pharmaceutical care and health management, analyze their internal connections both in present background and implementation process.Further development and practice of pharmaceutical care under the new health management mod...
Discussion on the operation of outpatient intravenous admixture services in Nanjing Children's Hospital
WANG Zhiyu, LIU Qingqing, SHI Yali, ZHAO Xuxia
2014, 32(3): 228-230. doi: 10.3969/j.issn.1006-0111.2014.03.018
Abstract:
Objective To improve the function of outpatient intravenous admixture services, provide patients better medical services. Methods According to the characteristic of outpatient, the rationality of the operation of outpatient intravenous admixture se...
Investigation and analysis on rational clinical application of human serum album in 172 cases
WANG Dan, CHEN Hui, LIU Lihong, SUN Jili, HE Haiying, WANG Ling, MA Ping
2014, 32(3): 231-234. doi: 10.3969/j.issn.1006-0111.2014.03.019
Abstract(3213) PDF (502KB)(118)
Abstract:
Objective To evaluate the clinical application of human serum albumin for inpatients and provide evidence to its rational administration in our hospital. Methods 172 cases were randomly selected from the inpatients that treated with human serum al...
The status and future of small package of Chinese material medicine pieces in Shanghai
XI Qing
2014, 32(3): 235-237. doi: 10.3969/j.issn.1006-0111.2014.03.020
Abstract(2795) PDF (452KB)(155)
Abstract:
Small package of Chinese material medicine pieces has been gradually extended in major hospitals in Shanghai. It is a major reform occurred in the history of TCM deployment, which has important significance to improve recipe speed, dose accuracy and ...
Design and implementation of warehouse management information system data standard for military medicine
ZHAO Yanzhong, LI Mingjun, HE Wei, SUN Yue, WANG Zhe, NI Xiaofei, GUO Rui
2014, 32(3): 238-240. doi: 10.3969/j.issn.1006-0111.2014.03.021
Abstract:
Objective To discuss the importance of data coding standards for the application of information technology, and put forward a method to solve the identification of complex medical materials in database structure design. Methods utilization of stan...