2013 Vol. 31, No. 6
Display Method:
2013, 31(6): 401-404,423.
doi: 10.3969/j.issn.1006-0111.2013.06.001
Abstract:
Vascular disrupting agents (VDAs) are a novel class of the antitumor agents that selectively damage the established tumor vessel. This kind of agents can selectively damage the tumor vascular, which apply adequate oxygen and nutrient for tumor growth...
Vascular disrupting agents (VDAs) are a novel class of the antitumor agents that selectively damage the established tumor vessel. This kind of agents can selectively damage the tumor vascular, which apply adequate oxygen and nutrient for tumor growth...
2013, 31(6): 405-408,480.
doi: 10.3969/j.issn.1006-0111.2013.06.002
Abstract:
Chinese medicinal formula was the main form of Chinese clinical medicine. The compatibility mechanism was an important part of the modernization of Traditional Chinese Medicine. The study of Chinese medicine compound compatibility mechanism explored ...
Chinese medicinal formula was the main form of Chinese clinical medicine. The compatibility mechanism was an important part of the modernization of Traditional Chinese Medicine. The study of Chinese medicine compound compatibility mechanism explored ...
2013, 31(6): 409-411,435.
doi: 10.3969/j.issn.1006-0111.2013.06.003
Abstract:
Objective To optimize matrix formula and process conditions and control the quality of propranolol hydrochloride cream. Methods Emulsifying temperature, dosages of the stearic acid, glyceryl monostearate and Tween-80 were taken as variable factors...
Objective To optimize matrix formula and process conditions and control the quality of propranolol hydrochloride cream. Methods Emulsifying temperature, dosages of the stearic acid, glyceryl monostearate and Tween-80 were taken as variable factors...
2013, 31(6): 412-414,453.
doi: 10.3969/j.issn.1006-0111.2013.06.04
Abstract:
Objective To develop a HPLC method for simultaneous determination of four polyamines (putrescine, cadaverine, spermidine, spermine) in Candida albicans. Methods HPLC analysis was performed on a Shiseido C18 column(100 mm×3.0 mm, 3.0 μm) after benz...
Objective To develop a HPLC method for simultaneous determination of four polyamines (putrescine, cadaverine, spermidine, spermine) in Candida albicans. Methods HPLC analysis was performed on a Shiseido C18 column(100 mm×3.0 mm, 3.0 μm) after benz...
2013, 31(6): 415-417,461.
doi: 10.3969/j.issn.1006-0111.2013.06.005
Abstract:
Objective To study the effects of different density microneedle-roller arrays on transdermal delivery of triamcinolone acetonide. Methods The in vitro permeation characteristics through isolated nude mouse skin were studied by modified Franz diffu...
Objective To study the effects of different density microneedle-roller arrays on transdermal delivery of triamcinolone acetonide. Methods The in vitro permeation characteristics through isolated nude mouse skin were studied by modified Franz diffu...
2013, 31(6): 418-423.
doi: 10.3969/j.issn.1006-0111.2013.06.06
Abstract:
Objective To optimize the extraction technology of aloe. Methods The samples were scanned from 200 to 400 nm by ultraviolet spectrophotometry, then the average ultraviolet absorption was calculated in UVC, UVB and UVA. The quantity of aloin was de...
Objective To optimize the extraction technology of aloe. Methods The samples were scanned from 200 to 400 nm by ultraviolet spectrophotometry, then the average ultraviolet absorption was calculated in UVC, UVB and UVA. The quantity of aloin was de...
2013, 31(6): 424-427,466.
doi: 10.3969/j.issn.1006-0111.2013.06.007
Abstract:
Objective To evaluate the pharmacokinetics and relative bioavailability of sulfasalazine enteric-coated tablets from two different factories in healthy volunteers. Methods 24 healthy male volunteers were enrolled in the study.A single oral dose(50...
Objective To evaluate the pharmacokinetics and relative bioavailability of sulfasalazine enteric-coated tablets from two different factories in healthy volunteers. Methods 24 healthy male volunteers were enrolled in the study.A single oral dose(50...
2013, 31(6): 428-431,475.
doi: 10.3969/j.issn.1006-0111.2013.06.008
Abstract:
Objective To determine the acute toxicity of imperatorin on rats and mice, and the influence of imperatorin on the nervous system of mice and the cardiovascular and respiratory systems of beagle dogs. Methods intraperitoneal injection (ip) and int...
Objective To determine the acute toxicity of imperatorin on rats and mice, and the influence of imperatorin on the nervous system of mice and the cardiovascular and respiratory systems of beagle dogs. Methods intraperitoneal injection (ip) and int...
2013, 31(6): 432-435.
doi: 10.3969/j.issn.1006-0111.2013.06.009
Abstract:
Objective To optimize the extraction methods and develop a HPLC-DAD assay for the determination of three effective ingredients in Moutan Coretex. Methods The analysis was performed on an Agilent ZORBAX Eclipse Plus (4.6 mm×150 mm, 5 μm) column wit...
Objective To optimize the extraction methods and develop a HPLC-DAD assay for the determination of three effective ingredients in Moutan Coretex. Methods The analysis was performed on an Agilent ZORBAX Eclipse Plus (4.6 mm×150 mm, 5 μm) column wit...
2013, 31(6): 436-437,472.
doi: 10.3969/j.issn.1006-0111.2013.06.010
Abstract:
Objective To introduce the Origin software to enhance the pharmaceutical R & D personnel's level of the experimental data processing. Methods The application of Origin software in the data processing of several classic pharmaceutical experiments wa...
Objective To introduce the Origin software to enhance the pharmaceutical R & D personnel's level of the experimental data processing. Methods The application of Origin software in the data processing of several classic pharmaceutical experiments wa...
2013, 31(6): 438-441,158.
doi: 10.3969/j.issn.1006-0111.2013.06.011
Abstract:
Objective To study the effect of the new type of hemostat for nano-fibers tunic carbonized hair loaded drug (NTCH) on skin wound healing in rabbits. Methods Bilateral round wounds were made on the backs of rabbits.There were six wounds in each rab...
Objective To study the effect of the new type of hemostat for nano-fibers tunic carbonized hair loaded drug (NTCH) on skin wound healing in rabbits. Methods Bilateral round wounds were made on the backs of rabbits.There were six wounds in each rab...
2013, 31(6): 442-445.
doi: 10.3969/j.issn.1006-0111.2013.06.012
Abstract:
Objective To prepare 4-[1-alkyl-5-oxo-1H-1,2,4-triazol-4 (5H)-yl] benzoic acids (5), which was the key fatty acid chain pharmaceutical intermediates for the total synthesis of novel caspofungin-like cyclohexa lipopeptide antifungal agents. Methods ...
Objective To prepare 4-[1-alkyl-5-oxo-1H-1,2,4-triazol-4 (5H)-yl] benzoic acids (5), which was the key fatty acid chain pharmaceutical intermediates for the total synthesis of novel caspofungin-like cyclohexa lipopeptide antifungal agents. Methods ...
2013, 31(6): 446-447,469.
doi: 10.3969/j.issn.1006-0111.2013.06.013
Abstract:
Objective To prepare 2-substitudephenoxy-5-benzyloxypyrimidines and 2-substitudephenoxy-5-hydroxypyrimidines which had not been reported. Methods The target compounds were prepared from 2-chlorine-5-hydroxypyrimidine through hydroxy protection, Wi...
Objective To prepare 2-substitudephenoxy-5-benzyloxypyrimidines and 2-substitudephenoxy-5-hydroxypyrimidines which had not been reported. Methods The target compounds were prepared from 2-chlorine-5-hydroxypyrimidine through hydroxy protection, Wi...
2013, 31(6): 448-450.
doi: 10.3969/j.issn.1006-0111.2013.06.014
Abstract:
Objective To synthesis the new anti-osteoporotic risedronate sodium. Methods Nicotinic acid was used as raw material, by esterification, condensation, Willgerodt reaction and hydrolysis steps to get the key intermediate 3-pyridine acetic acid hydr...
Objective To synthesis the new anti-osteoporotic risedronate sodium. Methods Nicotinic acid was used as raw material, by esterification, condensation, Willgerodt reaction and hydrolysis steps to get the key intermediate 3-pyridine acetic acid hydr...
2013, 31(6): 451-453.
doi: 10.3969/j.issn.1006-0111.2013.06.015
Abstract:
Objective To establish an HPLC method for determination of baicalin and cinnamic acid in Bianyan oral solution simultaneously. Methods The Agilent Eclipse XDB-C18(4.6 mm×150 mm, 5 μm)was used, the mobile phase consisted of ACN-2% acetic acid (23:7...
Objective To establish an HPLC method for determination of baicalin and cinnamic acid in Bianyan oral solution simultaneously. Methods The Agilent Eclipse XDB-C18(4.6 mm×150 mm, 5 μm)was used, the mobile phase consisted of ACN-2% acetic acid (23:7...
2013, 31(6): 454-458.
doi: 10.3969/j.issn.1006-0111.2013.06.016
Abstract:
Objective To determine whether Xiao Chai Hu Tang have liver toxicity and the sources of toxicity. Methods HPLC-TOF/MS method and the MTT were used to assay the Xiao Chai Hu Tang chemical composition and the survival of SMMC-7721 cells, respectivel...
Objective To determine whether Xiao Chai Hu Tang have liver toxicity and the sources of toxicity. Methods HPLC-TOF/MS method and the MTT were used to assay the Xiao Chai Hu Tang chemical composition and the survival of SMMC-7721 cells, respectivel...
2013, 31(6): 459-461.
doi: 10.3969/j.issn.1006-0111.2013.06.017
Abstract:
Objective To establish a HPLC method for determination of silybin contents in Gan'an capsule. Methods Angilent Zorbax SB C18(4.6 mm×250 mm, 5 μm) column was used with 1% acetic acid:methanol=50:50 as the mobile phase. The flow rate was 1.0 ml/min,...
Objective To establish a HPLC method for determination of silybin contents in Gan'an capsule. Methods Angilent Zorbax SB C18(4.6 mm×250 mm, 5 μm) column was used with 1% acetic acid:methanol=50:50 as the mobile phase. The flow rate was 1.0 ml/min,...
2013, 31(6): 462-463.
doi: 10.3969/j.issn.1006-0111.2013.06.018
Abstract:
Objective To explore the effect of combined therapy with alprostadil and mecobalamin injection on diabetic foot. Methods By simple randomization, the patients were divided into the observe group (accepted treatment of alprostadil and mecobalamin in...
Objective To explore the effect of combined therapy with alprostadil and mecobalamin injection on diabetic foot. Methods By simple randomization, the patients were divided into the observe group (accepted treatment of alprostadil and mecobalamin in...
2013, 31(6): 464-466.
doi: 10.3969/j.issn.1006-0111.2013.06.019
Abstract:
Objective To study the anti-inflammatory and analgesic effects of Tuishao granule, and provide the basis for clinical studies of the drug. Methods The analgesic effects of Tuishao granule were evaluated by the writhing reaction of mice induced by g...
Objective To study the anti-inflammatory and analgesic effects of Tuishao granule, and provide the basis for clinical studies of the drug. Methods The analgesic effects of Tuishao granule were evaluated by the writhing reaction of mice induced by g...
2013, 31(6): 467-469.
doi: 10.3969/j.issn.1006-0111.2013.06.020
Abstract:
Objective To explore the efficacy of WuzhiPian in the treatment of alcoholic Hepatitis. Methods 110 patients with alcoholic hepatitis were randomly divided into the observed group(accepted treatment of WuzhiPian) and the control group(accepted tre...
Objective To explore the efficacy of WuzhiPian in the treatment of alcoholic Hepatitis. Methods 110 patients with alcoholic hepatitis were randomly divided into the observed group(accepted treatment of WuzhiPian) and the control group(accepted tre...
2013, 31(6): 470-472.
doi: 10.3969/j.issn.1006-0111.2013.06.021
Abstract:
To explore the pharmaceutical department how to combine own characteristics and updating ideas in highly modern of pharmaceutical companies based on construction process and the current situation of Pharmaceutical Department of Changzheng Hospital af...
To explore the pharmaceutical department how to combine own characteristics and updating ideas in highly modern of pharmaceutical companies based on construction process and the current situation of Pharmaceutical Department of Changzheng Hospital af...
2013, 31(6): 473-475.
doi: 10.3969/j.issn.1006-0111.2013.06.022
Abstract:
Logistics visualization is a developing trend of military logistics informatization. A solution was proposed in this paper which the information management in the whole process of military medical supply would be achieved based-on logistics visualiza...
Logistics visualization is a developing trend of military logistics informatization. A solution was proposed in this paper which the information management in the whole process of military medical supply would be achieved based-on logistics visualiza...
2013, 31(6): 476-477.
doi: 10.3969/j.issn.1006-0111.2013.06.023
Abstract:
Objective To explore the characteristics of medical materials support in earthquake relief mission in subtropical forest areas and put forward some suggestions and countermeasures of medical materials support. Methods Experiences and practices of m...
Objective To explore the characteristics of medical materials support in earthquake relief mission in subtropical forest areas and put forward some suggestions and countermeasures of medical materials support. Methods Experiences and practices of m...
2013, 31(6): 478-480.
doi: 10.3969/j.issn.1006-0111.2013.06.024
Abstract:
Objective To examine the dose measurement methods of popular oral liquid OTC TCM, and to evaluate the recognition accuracy of patient. Methods The types and features of oral liquid measurement methods provided with packages obtained from hospital p...
Objective To examine the dose measurement methods of popular oral liquid OTC TCM, and to evaluate the recognition accuracy of patient. Methods The types and features of oral liquid measurement methods provided with packages obtained from hospital p...
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