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2012 Vol. 30, No. 2

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New progress of protein crystallization and drug design
CHEN Wei-jing, ZHONG Wei-qing
2012, 30(2): 81-85,136. doi: 10.3969/j.issn.1006-0111.2012.02.001
Abstract:
Protein was the foundation of all life, and its function was closely related to its three-dimensional structure. The structure information of proteins was crucial for the determination of drug targets and helped scientists to discover new drug target...
Progress on micro-needles transdermal drug delivery system
WAN Zhan, ZHOU Jian, HAN Mei-na, YANG Feng
2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
Abstract(5838) PDF (1612KB)(1247)
Abstract:
Micro-needles transdermal drug delivery system became the hot spot in the field of transdermal drug delivery system, which had the double advantages in both injection drug delivery and transdermal drug delivery. It also had the merits of fast absorpt...
Advance in function of the eukaryotic elongation factor eEF1A
CHENG Jun, RUI Yao-cheng
2012, 30(2): 89-91,124. doi: 10.3969/j.issn.1006-0111.2012.02.003
Abstract:
Eukaryotic elongation factors(eEFs)was a kind of important molecules that assist in elongating the polypeptide chain in the protein biosynthesis of the organisms. It had two subtypes in eukaryotic organism:eEF1 and eEF2. One subtype of eEF1:eEF1A pla...
Advances in active ingredients and action mechanism of TCM in treatment of hepatic fibrosis
SUN Lei, DENG Hua-ping, XI Zhong-xin, LI Xia, SUN Lian-na
2012, 30(2): 92-95,127. doi: 10.3969/j.issn.1006-0111.2012.02.004
Abstract:
Hepatic fibrosis was the common feature of pathology in almost all patients with chronic liver injury, which led to cirrhosis gradually and liver cancer ultimately. The anti-hepatic fibrosis active ingredients from TCM, including flavones, alkaloids,...
Progress on anti-HBV constituents from traditional Chinese medicine
JIN Qian-xing, ZHOU Feng
2012, 30(2): 96-99,148. doi: 10.3969/j.issn.1006-0111.2012.02.005
Abstract:
Objective To introduce advances of anti-HBV bioactive substances from traditional Chinese medicine. Methods Anti-HBV constituents from traditional Chinese medicine research were reviewed, which were focused on the saponins, alkaloids, flavones and...
Sesquiterpenes from the South China Sea gorgonian Muriceopsis flavida
LIU Tao-fang, TANG Hua, GONG Wei, SUN Peng, LIU Bao-shu, LI Ling, ZHANG Wen
2012, 30(2): 100-102. doi: 10.3969/j.issn.1006-0111.2012.02.006
Abstract(5727) PDF (837KB)(360)
Abstract:
Objective To study the chemical constituents of the South China Sea gorgonian Muriceopsis flavida. Methods The compounds were isolated and purified by repeated column chromatographies including normal-phase silica gel, Sephadex LH-20 and semi-prep...
Protective effect of α-lipoic acid on noise induced hearing loss in guinea pigs
WANG Xi-ying, ZHU Quan-gang, GAO Jing, GAO Shen, PAN Yong-hua, MIAO Peng
2012, 30(2): 103-106. doi: 10.3969/j.issn.1006-0111.2012.02.007
Abstract(4927) PDF (842KB)(601)
Abstract:
Objective To observe the protection of free radical scavenger: α-lipoic acid on the explosive hearing loss in rats. Methods 24 pure white male guinea pigs weighted between 250~300 g, which were randomly divided into α-lipoic acid low, medium, high...
Determination of bacterial endotoxin in human coagulation factor Ⅷ by kinetic turbidimetric limulus test
SHENG Feng-xian, XIONG Ke-qiang, WANG Hui-zhi, ZHANG You-jie, GAO Li-ping
2012, 30(2): 107-108,114. doi: 10.3969/j.issn.1006-0111.2012.02.008
Abstract:
Objective To establish a method for determination of bacterial endotoxin in human coagulation factor Ⅷ by kinetic turbidimetric limulus test. Methods Based on interference experiment, the endotoxin was added in the samples, whose recovery should b...
Data mining of antibiotic prophylactic use for cesarean section patients
FU Xiang, YANG Zhang-wei, CHEN Sheng-xin, CHEN Chang-hong, HE Yu-tao
2012, 30(2): 109-114. doi: 10.3969/j.issn.1006-0111.2012.02.009
Abstract(5516) PDF (864KB)(438)
Abstract:
Objective To establish, compare and evaluate the classification models of antibiotic prophylactic use for cesarean section patients for the targeted intervention in future. Method PASW® Modeler 13 was applied to establish classification models and...
Analysis of volatile constituents in Caulis Sinomenii by GC-MS
CHEN Jun, ZHOU Jin, HE Yun-xin, FENG Chun-hua, ZHANG Guo-qing
2012, 30(2): 115-117. doi: 10.3969/j.issn.1006-0111.2012.02.010
Abstract(5411) PDF (831KB)(378)
Abstract:
Objective To establish the determination method for chemical constituents of the volatile oil in Sinornenium actum(Thunb.)Rehd.et Wils by gas chromatography-mass spectrometry(GC-MS). Method The volatile oil was extracted from Sinornenium actum(Thu...
Determination of the sulfate content in sulfated fucans by barium sulfate turbidity
CHEN Qian, MA Tian-xiang, GUO Hong-ju, SHI Ning, WU Jiu-hong
2012, 30(2): 118-120. doi: 10.3969/j.issn.1006-0111.2012.02.011
Abstract(6395) PDF (822KB)(1082)
Abstract:
Objective To determine the sulfate content in sulfated fucans (FPS) by Barium sulfate turbidity. Methods With spectrophotometer at 360 nm, the sulfate content was determined by Barium Sulfate Turbidity. Results There was a good linearity (r2=0.9...
Effects of total aglycone of centella asiatica on depressed rats by chronic unpredicted mild stress
CAO Wei-wei, XU Jiang-ping, ZHAO Na-ping, WANG Jing, ZHANG Li
2012, 30(2): 121-124. doi: 10.3969/j.issn.1006-0111.2012.02.012
Abstract(5532) PDF (846KB)(558)
Abstract:
Objective To investigate effects of total aglycone of centella asiatica on depressed rats and study plasma levels of adrenocorticotropic hormone (ACTH) and cortisol (CORT). Methods The chronic mild stress depressed rats were produced by long-term ...
Clinical observation of Chanhuning and ganciclovir in treatment of children with infections mononucleosis
LUO Wei-hua, SHI Yan-ming
2012, 30(2): 125-127. doi: 10.3969/j.issn.1006-0111.2012.02.013
Abstract(4549) PDF (822KB)(415)
Abstract:
Objective To observe the clinical efficacy of Chanhuning and ganciclovir in treatment of children with infections mononucleosis. Method 76 patients were randomly divided into the treatment group (38 cases) and the control group (38 cases), the tre...
Analysis on rationality of antibiotics choice after blood culture and drug sensitivity tests
JIANG Yun-xia, JIN Rou-nan, WANG Bin, MA Wei-qi, ZHAN Qi
2012, 30(2): 128-130,145. doi: 10.3969/j.issn.1006-0111.2012.02.014
Abstract:
Objective To analysis the distribution and drug resistance of pathogens isolated from blood cultures in hospitalized patients in order to guide the rational application of antibiotics agents. Methods 230 cases of blood culture results in hospitali...
Meta-analysis of gemcitabine versus vinorelbine combined with cisplatin in treatment of advanced non-small cell lung cancer
HE Zhi-gao, BAO Si-wei, ZHAI Xiao-bo
2012, 30(2): 131-136. doi: 10.3969/j.issn.1006-0111.2012.02.015
Abstract(6021) PDF (838KB)(354)
Abstract:
Objective To compare and evaluate the effectiveness and security of gemcitabine versus vinorelbine combined with cisplatin in treatment of advanced non-small cell lung cancer by Meta-analysis. Methods PubMed database and CHKD database were searche...
Meta analysis on cinepazide maleate in treatment of diabetic peripheral neuropath
HUANG Qiu-ming, TU Xue-song, YAN Qiong, SHI Chuan-lin
2012, 30(2): 137-142. doi: 10.3969/j.issn.1006-0111.2012.02.016
Abstract(5367) PDF (848KB)(377)
Abstract:
Objective To assess the efficacy and safety of Cinepazide Maleate(CPZD) in the treatment of diabetic peripheral neuropath(DPN),with evidence-based medicine methods. Methods By retrieving related database,such as Medline(1977~2011.11), CNKI(1994~20...
Regulation changes in the clinical efficacy evaluation of Traditional Chinese
CHENG Long, LIU Bing-lin, LV Jia-kang
2012, 30(2): 143-145. doi: 10.3969/j.issn.1006-0111.2012.02.017
Abstract(4295) PDF (802KB)(638)
Abstract:
The original and current regulations were reviewed. Three key points of regulation changes in efficacy evaluation were summarized, such as indications for the syndromes of Traditional Chinese Medicine, Traditional Chinese medicine for the disease and...
Analysis and interventions of dispensing errors in inpatient pharmacy
CAO Jin-hua, ZHOU Yan-ni, WANG Hui, HUANG Yu-feng
2012, 30(2): 146-148. doi: 10.3969/j.issn.1006-0111.2012.02.018
Abstract(5897) PDF (818KB)(461)
Abstract:
Objective To explore practical measures to reduce the pharmacies dispensing errors, and improve the quality of drug deployment work. Methods The dispensing errors recorded in the Drug deployment errors registration from January 2009 to December 20...
The pharmaceutical care on the empyrosis infected pediatric patient joined by clinical pharmacists
HE Ju-ying, TANG Min, XIA Pei-yuan
2012, 30(2): 149-151. doi: 10.3969/j.issn.1006-0111.2012.02.019
Abstract(5133) PDF (819KB)(333)
Abstract:
Objective To investigate the role of clinical pharmacists in the treatment of severely infected patients. Method Clinical pharmacists took part in the consultations of empyrosis infected pediatric patient in department of burn, gave specific opini...
Analysis of irrational prescriptions in emergency department
CHEN Yun-yan, PENG Qing-hua, ZHENG Dong
2012, 30(2): 152-153,158. doi: 10.3969/j.issn.1006-0111.2012.02.020
Abstract:
Objective To analyze the irrational drug use in the emergency department of our hospital, improve the quality of prescription and promote rational drug use in clinic. Methods 1 080 Prescriptions from January to June were randomly extracted from em...
Exploration of the design and implementation of pharmacology experiment in undergraduate students
LI Tie-jun, ZHANG Yue-fan, RUI Yao-cheng
2012, 30(2): 154-155. doi: 10.3969/j.issn.1006-0111.2012.02.021
Abstract(4902) PDF (795KB)(424)
Abstract:
The pharmacology experiment was an important ingredient of pharmacology teaching. The experiment named anti-inflammatory effect of glucocorticoids was re-designed and implemented by undergraduate students. The ability of the undergraduate students on...
Practice on teaching design experimentation course of determination of two-component system by ultraviolet spectroscopy
WEN Jun, ZHOU Ting-ting, FAN Guo-rong
2012, 30(2): 156-158. doi: 10.3969/j.issn.1006-0111.2012.02.022
Abstract(5217) PDF (802KB)(438)
Abstract:
An attempt to apply designing experiment on determination two-component system by ultraviolet spectroscopy was made during the experiment teaching of analysis chemistry, whose purpose was to enable students to deepen understanding the principle in qu...
Exploration of cultivation of scientific innovation ability in pharmacy undergraduate internship
CAO Yong-bing, LIU Yi-qing, LIN Ling, LIU Wei, JIANG Yuan-ying
2012, 30(2): 159-160. doi: 10.3969/j.issn.1006-0111.2012.02.023
Abstract(4488) PDF (794KB)(573)
Abstract:
Pharmacy undergraduate practice was important to improve the professional skills and research capacity of pharmacy undergraduates. Undergraduate practice could let the students practice and consolidate the basis knowledge of pharmacy which was learne...