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2012 Vol. 30, No. 3

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Progress and prospect on Polypill
XIANG Li, JIANG Peng, HU Yao-hua, WANG Shu-ping, ZHANG Wei-dong, LIU Run-hui
2012, 30(3): 161-164,228. doi: 10.3969/j.issn.1006-0111.2012.03.001
Abstract:
The morbidity of chronic diseases such as cardiovascular diseases, which were becoming the main mortality of human death, was increasing steadily. As a result of its multi-induced character, it was impossible to cure those kind of diseases by mono-th...
Progress on the role of Ribosomal Protein S3a in regulation of proliferation, differentiation and apoptosis in tumor cells
LI Ying-hua, HU Zhen-lin, ZHANG Jun-ping
2012, 30(3): 165-167,225. doi: 10.3969/j.issn.1006-0111.2012.03.003
Abstract(5629) PDF (1681KB)(1032)
Abstract:
Objective To review the role of Ribosomal Protein S3a in regulation of proliferation, differentiation and apoptosis in tumor cells. Methods The relevant literatures were collected to make a summary of Ribosomal Protein S3a in regulation of proliferat...
Progress on type and formulation of mosquito repellent
ZHENG Lu-lu, SONG Hong-tao
2012, 30(3): 168-170,202. doi: 10.3969/j.issn.1006-0111.2012.03.004
Abstract(6257) PDF (1663KB)(1092)
Abstract:
Natural repellent had the characteristic of safety, environmental friendliness, little toxicity and so on. Its research was mainly concentrated on screening the high active constituent. By searching literatures of recent years, the current situation ...
Progress on anti-radiation natural medicines
WANG Qing-bin, HAN Ting, SUN Lian-na, SHANG Wen
2012, 30(3): 171-174,177. doi: 10.3969/j.issn.1006-0111.2012.03.005
Abstract:
Objective In recent years, with the worsening situation of the international nuclear crisis as well as people prolonged exposure to low doses of radiation in the surrounding environment in daily lives, the research on radio-protective drugs was much ...
Progress on positron emission tomography drugs
CHEN Kai-yu, LI Xin-ping, CHEN Sheng-xin
2012, 30(3): 175-177. doi: 10.3969/j.issn.1006-0111.2012.03.006
Abstract(17241) PDF (858KB)(2104)
Abstract:
Because of the urgent needs of the medical advances and clinical diagnosis practice, positron emission tomography drugs were increasingly widely researched and used. The characteristics and the course of the development of positron emission tomograph...
Progress on drug treatment of depression
FAN Zhi-xiong, XIE He-hui
2012, 30(3): 178-181. doi: 10.3969/j.issn.1006-0111.2012.03.002
Abstract(5863) PDF (865KB)(977)
Abstract:
Depression was a common mental disorder. Nowdays, anti-depressants included tricyclic antidepressants, monoamine oxidase inhibitors and reversible selective monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, selective noradrenergi...
Clinical application of Reduning injection in pediatric
ZHANG Yu-bei
2012, 30(3): 182-184. doi: 10.3969/j.issn.1006-0111.2012.03.007
Abstract(7844) PDF (845KB)(1758)
Abstract:
Objective To evaluate the clinical effect of Reduning injection in the pediatric disease. Methods The pertinent literatures on pediatrician using Reduning injection in recent years were reviewed and analyzed. Results and Conclusion Reduning injection...
Stimulation of NFκB activity by the agonist inhibition from Lipoxin A4, Protectin D1 and Resolvin D1
BAO Hua-yan, YAN Jun, LI Ke, LIU Peng
2012, 30(3): 185-188. doi: 10.3969/j.issn.1006-0111.2012.03.008
Abstract(5717) PDF (980KB)(603)
Abstract:
Objective To examine effect of lipoxin A4 (LXA4), protectin D1 (ProD1) or resolvin D1 (RvD1) on the activity of NFκB and their action mechanism. Methods The CHO cells, stably expressing NFκB luciferase reporter gene, were treated with LPS, HSP70, HMG...
Preparation and in vitro releasing of sirolimus-nanostructured lipid carriers dispension
WU Hao, SONG Hong-tao
2012, 30(3): 189-193. doi: 10.3969/j.issn.1006-0111.2012.03.009
Abstract:
Objective To optimize the preparation and study in vitro releasing of SRL-NLC dispersion. Methods Central composite design-response surface methodology was used to optimize dispersion formulation,then in vitro releasing in 0.4% SDS(sodium lauryl sulf...
Identification of different breeds of Fagopyrum tataricum by differential thermal analysis and near infrared reflectance spectroscopy
LIN Bing, LIN Jin-ming, SHAO Mei-hong, SUN Jia-yan, QIN Lu-ping
2012, 30(3): 194-196. doi: 10.3969/j.issn.1006-0111.2012.03.010
Abstract(5848) PDF (916KB)(1066)
Abstract:
Objective To identify different breeds of Fagopyrum tataricum by differential thermal analysis and near infrared reflectance spectroscopy. Methods TG/DTA and thermal analysis were both used to scan and analyze the thermal map of 11 breeds of F. tarta...
Study on pharmacokinetics and relative bioavailability of nimodipine orally disintegrating tablet
GAO Yue, YANG Ling, WU Rong
2012, 30(3): 197-202. doi: 10.3969/j.issn.1006-0111.2012.03.011
Abstract(5607) PDF (916KB)(722)
Abstract:
Objective To research the pharmacokinetics and relative bioavailability of Nimodipine rapid disintegeating tablet in human body, which was compared with Nimodipine market tablets. Methods 6 cases of health volunteer were divide into two groups random...
Synthesis and effect of novel 1-(1H-benzimidazole-2-yl) -urea derivatives as human acrosin inhibitors
FAN Yong-zheng, CHEN Qian-qian, LIU Bo-shi, ZHAO Jun-tao, TIAN Wei, ZHOU You-jun, LV Jia-guo, ZHU Ju
2012, 30(3): 203-206,210. doi: 10.3969/j.issn.1006-0111.2012.03.012
Abstract:
Objective To design and synthesize novel 1-(1H-benzimidazole-2-yl)urea compounds on the basis of the active site of human acrosin. Methods The compounds were designed by computer modeling and synthesized. Results Ten 1-(1H-benzimidazole-2-yl)urea com...
Identification of volatility components of Shexiang Baoxin pill in rat plasma by GC-MS
GUO Li-an, WANG Shu-ping, XIANG Li, JIANG Peng, ZHANG Wei-dong, LIU Run-hui
2012, 30(3): 207-210. doi: 10.3969/j.issn.1006-0111.2012.03.013
Abstract(6156) PDF (951KB)(859)
Abstract:
Objective To identify the volatile components in rat serum of Shexiang Baoxin Pill (SBP) by gas chromatography couples with mass spectrometry (GC-MS). Methods Serum samples from control and SBP administration rats were deproteinated by adding methano...
The effect of Jianbu Guanjie Capusule on level of correlative ingredients in osteoarthropathy model of rabbit
BAO Lei-lei, CHEN Hai-fei, BIAN Jun, YUAN Bing
2012, 30(3): 211-212,215. doi: 10.3969/j.issn.1006-0111.2012.03.014
Abstract:
Objective To discuss the protection and mechanism of Jianbu Guanjie Capusule( JBGJ capsule) to the knee osteoarthritis of rabbit. Methods Thirty healthy New Zealand rabbits were divided into five groups randomly with parallel control methods.The five...
Therapeutic effect of Tiotropium bromide on moderate to severe chronic obstructive pulmonary disease
CHEN Yi, PU Jian-ying
2012, 30(3): 213-215. doi: 10.3969/j.issn.1006-0111.2012.03.015
Abstract(6422) PDF (853KB)(776)
Abstract:
Objective To investigate the effectiveness and safety of the inhalation of tiotropium bromide in the treatment of moderate to severe chronic obstructive pulmonary disease. Methods 35 cases with chronic obstructive pulmonary disease during 2010 June t...
Synthesis of several symmetric α-dione by coupling method
WANG Peng, LI Bin, DONG Jun-xing
2012, 30(3): 216-217. doi: 10.3969/j.issn.1006-0111.2012.03.016
Abstract(5856) PDF (856KB)(819)
Abstract:
Objective To design and synthesize octane-4,5-dione, decane-5,6-dione and dodecane-6, 7-dione with ethyl butyrate, ethyl pentannate and ethyl hexanoate as the corresponding starting materials. Methods TTarget products were synthesized by coupling rea...
The relationship between plasma concentration and clinical efficacy of quetiapine in treatment of schizophrenia with the same dose
DUAN Di, LING Ying-chun, ZHOU Yue-qin, WANG Ling-ying
2012, 30(3): 218-219. doi: 10.3969/j.issn.1006-0111.2012.03.017
Abstract(5968) PDF (849KB)(747)
Abstract:
Objective To study the relationship between steady-state plasma concentration and clinical efficacy of quetiapine in treatment of schizophrenia with the same dose. Methods 148 schizophrenia patients were treated with quetiapine with the same dose (60...
Comparison of two kinds of manufacturing technology on compound Fructus crataegi granule
ZHANG Chao-shen, YANG Lin, AN Ye, ZHONG Wei-chao, YAO Feng
2012, 30(3): 220-221. doi: 10.3969/j.issn.1006-0111.2012.03.018
Abstract(6499) PDF (842KB)(981)
Abstract:
Objective To establish the best manufacturing technology of compound Fructus crataegi granule. Method The craft of manufacturing between swing prilling and atomizing prilling was studied. The output , properties, solution in water and total flavonoid...
Determination of fluoxetine hydrochloride in plasma by HPLC
XU Xue-jun, TAO Qing, XU De-qin
2012, 30(3): 222-225. doi: 10.3969/j.issn.1006-0111.2012.03.019
Abstract(6682) PDF (885KB)(889)
Abstract:
Objective To establish and optimize a simple, rapid, reliable, high sensitive and high selective method for the determination of fluoxetine hydrochloride in plasma by high-performance liquid chromatographic (HPLC) so as to monitor the clinical drug u...
Determination of tectoridin and tectorigenin in Flos Puerariae lobata by HPLC
ZHAO Nan, LIU Dan, WANG Yan-ping, WANG Jin-feng, WEI Ying
2012, 30(3): 226-228. doi: 10.3969/j.issn.1006-0111.2012.03.020
Abstract(6396) PDF (882KB)(865)
Abstract:
Objective To establish an HPLC method for the determination of Tectoridin and Tectorigenin in Flos Puerariae lobata. Method The separation was performed on Agilent -C18 column(4.6 mm×250 mm,5 μm),using a mobile phase with methanol-acetonitrile-water(...
Inventory management and think of second order storeroom under "zero inventory" model
ZHOU Bo-bo, CHEN Ya-mei
2012, 30(3): 229-231. doi: 10.3969/j.issn.1006-0111.2012.03.021
Abstract(6238) PDF (851KB)(947)
Abstract:
Objective To discuss the managed method of second order drug storeroom inventory under "zero inventory" model, and take advantages of "zero inventory" management, find the countermeasure, and ensure clinic drug use. Methods The model of "zero invento...
The survey on the situation of the medical information spreading in China
LIU Yi-qing, HUANG Xiao-bo, NI Xing-ke, LU Min, ZHANG Hong-wu
2012, 30(3): 232-234,238. doi: 10.3969/j.issn.1006-0111.2012.03.022
Abstract:
Objective To discuss the situation and feature of the medical information spreading in China. Methods A quantitative questionnaire survey for 200 general individuals from Beijing and Wuhan, and 80 doctors in Beijing, Hubei, Jiangsu and Guangdong was ...
Research on prescription behavior using electronic prescription data
WANG Chun-yan, SHU Li-xin, HAN bing
2012, 30(3): 235-238. doi: 10.3969/j.issn.1006-0111.2012.03.023
Abstract(5665) PDF (894KB)(757)
Abstract:
Objective To investigate the application of electronic prescriptions data in prescribing behavior research. Methods 2010 annual electronic prescription information diagnosis of peptic ulcer were collected in a district-level central hospital, SPSS(ve...
Preliminary discussion on application of HIS in outpatient pharmacy
SHI En-zhou, HUANG Yu-feng, CAO Jin-hua, BIAN Ya-lan
2012, 30(3): 239-240. doi: 10.3969/j.issn.1006-0111.2012.03.001
Abstract(1577) PDF (908KB)(786)
Abstract:
Objective To improve the level of management of outpatient pharmacy in our hospital.Methods Power builder 6.5 software and data-mining technology were applied based on original hospital information system, the outpatient pharmacy information system w...