2002 Vol. 20, No. 4
Display Method:
2002, (4): 199-200.
Abstract:
OBJECTIVE To search for the efficacy and side effects of tiopconin for injection in treating jaundice viral hepatitis. METHODS 114 patients were randmoly divided into 2 groups, 58 cases as a treatment group were administed tiopconin for injection 0.2g in 5% glucose solution 250ml by intravenous infusion, 56 cases as a comparison group received conventional drugs. RESULTS After the course of treatment, the symptom and sign of the treatment group was better than the comparison group (P <0.05). Tiopconin for injection can improve the reproduction of the toxin to the liver. Side effects had not been found. CONCLUSION Tiopconin for injection is an effective agent for treatment of jaundice viral hepatitis. So it is worth spreading.
OBJECTIVE To search for the efficacy and side effects of tiopconin for injection in treating jaundice viral hepatitis. METHODS 114 patients were randmoly divided into 2 groups, 58 cases as a treatment group were administed tiopconin for injection 0.2g in 5% glucose solution 250ml by intravenous infusion, 56 cases as a comparison group received conventional drugs. RESULTS After the course of treatment, the symptom and sign of the treatment group was better than the comparison group (P <0.05). Tiopconin for injection can improve the reproduction of the toxin to the liver. Side effects had not been found. CONCLUSION Tiopconin for injection is an effective agent for treatment of jaundice viral hepatitis. So it is worth spreading.
2002, (4): 201-204.
Abstract:
OBJECTIVE To research the effect of carrier on dries micropowder inhaler(DMPI) deposition in vitro, and select the suitable carrier and the forming method (FM) for inhalers. METHODS DMPI prepared by spray drying techniques(SDT) with the aqueous solution of drug(salbutamal) and carrier (lactose or mannitol) and physical mixing techniques (PMT) after drug and carrier spray drying respectively. DMPI were aerosolized by Cyclo-haler and their mode of deposition in lung was evaluated in vitro using a twin impinger(TI). RESULTS Dramatically improved inhalation properties of the DMPI with carrier mannitol by SDT,i. e. a two-fold increase in delivery to deep lung, were found in vitro compared with the DMPI by PMT. But the inhalation properties didn't change after adding 2% poloxamer. Improved inhalation was also found with carrier lactose after adding 2% poloxamer but no significant difference with SDT or PMT. CONCLUSION An ideal DMPI could obtained by SDT using carrier mannitol.
OBJECTIVE To research the effect of carrier on dries micropowder inhaler(DMPI) deposition in vitro, and select the suitable carrier and the forming method (FM) for inhalers. METHODS DMPI prepared by spray drying techniques(SDT) with the aqueous solution of drug(salbutamal) and carrier (lactose or mannitol) and physical mixing techniques (PMT) after drug and carrier spray drying respectively. DMPI were aerosolized by Cyclo-haler and their mode of deposition in lung was evaluated in vitro using a twin impinger(TI). RESULTS Dramatically improved inhalation properties of the DMPI with carrier mannitol by SDT,i. e. a two-fold increase in delivery to deep lung, were found in vitro compared with the DMPI by PMT. But the inhalation properties didn't change after adding 2% poloxamer. Improved inhalation was also found with carrier lactose after adding 2% poloxamer but no significant difference with SDT or PMT. CONCLUSION An ideal DMPI could obtained by SDT using carrier mannitol.
2002, (4): 204-206.
Abstract:
OBJECTIVE To investigate the effection of hollow liquid suppository of curcuma volatile oil compound on gynecopathy. METHODS To introduce the prescription and the manufacturing process of hollow liquid suppository of curcuma volatile oil compound, and determine it's difference of weight, time in melt and force to breakage. RESULTS:The results of the determination were up to the stipulation of 95th pharmacopeia. The suppository was non irritation on vaginal mucomembrance in rabbit experiment and used in 56 cases of mycosis vaginitis which the cure rate was 50%,rate of effective was 16.07% and the total effective rate was 91.07%. CONCLUT-SION:The hollow liquid suppository of curcuma volatile oil compound are effective on gynecopathy.
OBJECTIVE To investigate the effection of hollow liquid suppository of curcuma volatile oil compound on gynecopathy. METHODS To introduce the prescription and the manufacturing process of hollow liquid suppository of curcuma volatile oil compound, and determine it's difference of weight, time in melt and force to breakage. RESULTS:The results of the determination were up to the stipulation of 95th pharmacopeia. The suppository was non irritation on vaginal mucomembrance in rabbit experiment and used in 56 cases of mycosis vaginitis which the cure rate was 50%,rate of effective was 16.07% and the total effective rate was 91.07%. CONCLUT-SION:The hollow liquid suppository of curcuma volatile oil compound are effective on gynecopathy.
The pathological studies on Dachengqi decoction for treating experimental pulmonary edema in rabbits
2002, (4): 215-220.
Abstract:
OBJECTIVE In order to investigate the mechanism of the action of Da-cheng-qi-decoction (DD) in treating acute pulmonary edema, Rabbit model of experimental pulmonary edema was made with injecting oleic acid (group B), and then treated with DD (group C). Randomly 10 cases of normal rabbit without any treatment were served as the normal control group (group A). RESULT:In group B, the important pathological changes are interstitial and intra-alveolar edema, hemorrhage, hyaline thrombus in small pulmonary venules and hyaline membranes in the alveolar lumina. DD show a effection of improving above pathological changes, promoting growth of pneumocyte espectialy pneumocyte Ⅱ, reducing multi-organs injury. These findings indicate that it may be its mainly mechanism in treating with acute pulmonary edema by eliminating exudation, enhancing the growth of pneu-mocyte Ⅱ, adjusting the balance of ventilation-perfusion, protecting organs from injury and so on.
OBJECTIVE In order to investigate the mechanism of the action of Da-cheng-qi-decoction (DD) in treating acute pulmonary edema, Rabbit model of experimental pulmonary edema was made with injecting oleic acid (group B), and then treated with DD (group C). Randomly 10 cases of normal rabbit without any treatment were served as the normal control group (group A). RESULT:In group B, the important pathological changes are interstitial and intra-alveolar edema, hemorrhage, hyaline thrombus in small pulmonary venules and hyaline membranes in the alveolar lumina. DD show a effection of improving above pathological changes, promoting growth of pneumocyte espectialy pneumocyte Ⅱ, reducing multi-organs injury. These findings indicate that it may be its mainly mechanism in treating with acute pulmonary edema by eliminating exudation, enhancing the growth of pneu-mocyte Ⅱ, adjusting the balance of ventilation-perfusion, protecting organs from injury and so on.
2002, (4): 224-226.
Abstract:
OBJECTIVE To evaluate safety for skin of Hueizhilin ointment which containes resorcinol,sulfur, salicylic acid,et al. METHODS Acute toxicity test and skin hypersensitive test were used. RESULTS Hueizhilin oitment had no acute toxicity and chronic toxicity to rat skin. But It had middle irritation to rat skin. No hypersensitive reaction be taken place during treatment. CONCLUSION Hueizhilin ointment has no toxicity to the skin. It can be used in patients with onychomycosis, tinea manus and pedis.
OBJECTIVE To evaluate safety for skin of Hueizhilin ointment which containes resorcinol,sulfur, salicylic acid,et al. METHODS Acute toxicity test and skin hypersensitive test were used. RESULTS Hueizhilin oitment had no acute toxicity and chronic toxicity to rat skin. But It had middle irritation to rat skin. No hypersensitive reaction be taken place during treatment. CONCLUSION Hueizhilin ointment has no toxicity to the skin. It can be used in patients with onychomycosis, tinea manus and pedis.
2002, (4): 226-227.
Abstract:
OBJECTIVE To study effects of Bushenzhuanggu capsule on biochemical markers in hydrocortisone-induced osteoporotic rat models. METHODS The blood concentrations of calcium, phosphorus and ALP of hydrocortisone-induced osteoporotic rats were determined by clinical biochemical assay. RESULTS After treatment with Bushenzhuanggu capsule, the blood concentrations of calcium, phosphorus and ALP of hydrocortisone-induced osteoporotic rats were increased, the activity of ALP was decreased. CONCLUSION Bushenzhuanggu capsule has some therapeutic effects on hydrocortisone-induced osteoporotic rat models.
OBJECTIVE To study effects of Bushenzhuanggu capsule on biochemical markers in hydrocortisone-induced osteoporotic rat models. METHODS The blood concentrations of calcium, phosphorus and ALP of hydrocortisone-induced osteoporotic rats were determined by clinical biochemical assay. RESULTS After treatment with Bushenzhuanggu capsule, the blood concentrations of calcium, phosphorus and ALP of hydrocortisone-induced osteoporotic rats were increased, the activity of ALP was decreased. CONCLUSION Bushenzhuanggu capsule has some therapeutic effects on hydrocortisone-induced osteoporotic rat models.
2002, (4): 231-233.
Abstract:
OBJECTIVE To observe the effects of cerebral hemodynamics on different dosages of extract liquid of Lifusticum chuanxiong and Angelica in dogs. METHODS to record changes of cerebral blood flow(CBF) and blood pressure (BP) after feeding medicines by duodenum and process datum of every group of dogs by analysing datum statistically. RESULTS The average changeable range of CBF with extract liquid of Lifusticum and Angelica and positive medicines (Nao'an capsule) was significant and average changeable range of BP wasn't apparent as compared with solvent control group. CONCLUSION Extract liquid of Lifusticum and Angelica had effects on cerebral hemodynamics and increased CBF,but had no effects on changes of BP.
OBJECTIVE To observe the effects of cerebral hemodynamics on different dosages of extract liquid of Lifusticum chuanxiong and Angelica in dogs. METHODS to record changes of cerebral blood flow(CBF) and blood pressure (BP) after feeding medicines by duodenum and process datum of every group of dogs by analysing datum statistically. RESULTS The average changeable range of CBF with extract liquid of Lifusticum and Angelica and positive medicines (Nao'an capsule) was significant and average changeable range of BP wasn't apparent as compared with solvent control group. CONCLUSION Extract liquid of Lifusticum and Angelica had effects on cerebral hemodynamics and increased CBF,but had no effects on changes of BP.
2002, (4): 234-235.
Abstract:
OBJECTIVE To investigate the hepatoprotective activity of phenylpropanoid glycosides METHODS The hepatocytes injury was induced by D-Gal in vivo and vitro and the cell survival rate、LDH.、ALT、AST were measuremented. RESULTS phenylpropanoid glycosides can elevated the survival rate of hepatocytes and inhibition the LDH leakage to medium in vitro. It also can suppress the elevation of serum ALT and AST induced by D-Gal in vivo. CONCLUSION:phenylpropanoid glycosides have significant protective effect to hepatocyes injury induced by D-Gal.
OBJECTIVE To investigate the hepatoprotective activity of phenylpropanoid glycosides METHODS The hepatocytes injury was induced by D-Gal in vivo and vitro and the cell survival rate、LDH.、ALT、AST were measuremented. RESULTS phenylpropanoid glycosides can elevated the survival rate of hepatocytes and inhibition the LDH leakage to medium in vitro. It also can suppress the elevation of serum ALT and AST induced by D-Gal in vivo. CONCLUSION:phenylpropanoid glycosides have significant protective effect to hepatocyes injury induced by D-Gal.
2002, (4): 236-237.
Abstract:
OBJECTIVE A quantitative method was developed for the determination of rutaecarpine in Zuojin Wan by HPLC. METHOD The chromatographic conditions include column Intersil C18, mobile phase:acetonitrile-10% acetonitrile (50:50), flow rate 1 ml·min-1, wavelength 345nm. RESULTS The number of theoretical plates caculated by rutaecarpine peak was 2100, The regression equation of rutaecarpine was Y=-0.2197+0.000000349X(r=0.9999) and the liner range was 12-60μg·ml-1. The average recovery of rutaecarpine was 96.9% (n=5),RSD 3.7%. The measurable lowest limit of rutaecarpine was 0.1μg·ml-. CONCLUSION The method is sensitive, rapid and accurate.
OBJECTIVE A quantitative method was developed for the determination of rutaecarpine in Zuojin Wan by HPLC. METHOD The chromatographic conditions include column Intersil C18, mobile phase:acetonitrile-10% acetonitrile (50:50), flow rate 1 ml·min-1, wavelength 345nm. RESULTS The number of theoretical plates caculated by rutaecarpine peak was 2100, The regression equation of rutaecarpine was Y=-0.2197+0.000000349X(r=0.9999) and the liner range was 12-60μg·ml-1. The average recovery of rutaecarpine was 96.9% (n=5),RSD 3.7%. The measurable lowest limit of rutaecarpine was 0.1μg·ml-. CONCLUSION The method is sensitive, rapid and accurate.
2002, (4): 240-242.
Abstract:
OBJECTIVE To study the determination method of self-emulsifying Curcuma oil soft capsule. METHODS The content of soft capsules was diluted by anhydrous alcohol, and then colored by sulfuric acid-vanillin reagent. RESULTS The absorbance was measured at (520±2) nm. Curcumenol revealed linearity over the arrange of 40-320μg·ml-1, the average recovery was 96.59%,and RSD was 1.03%. CONCLUSION This method is accurate, reliable, and it is suitable for the content of determination of self-emulsifying curcuma oil soft capsules.
OBJECTIVE To study the determination method of self-emulsifying Curcuma oil soft capsule. METHODS The content of soft capsules was diluted by anhydrous alcohol, and then colored by sulfuric acid-vanillin reagent. RESULTS The absorbance was measured at (520±2) nm. Curcumenol revealed linearity over the arrange of 40-320μg·ml-1, the average recovery was 96.59%,and RSD was 1.03%. CONCLUSION This method is accurate, reliable, and it is suitable for the content of determination of self-emulsifying curcuma oil soft capsules.
2002, (4): 244-245.
Abstract:
OBJECTIVE To evaluate the economic effectiveness in different pharmaco-therapeutic schemes for patients with stress ulcer. METHODS 119 patients with stress ulcer were divided into 3 groups randomly. They received respectively one of three therapeutic shemes, A:aminomethylbenzoic acid combined with cimetidine, B:san-dostatin,C:omeprazole combined with thrombin, The date were evaluatde with cost-effectiveness analysis. RESULTS The effective ratio of three therapeutic shemes were 59.46%,87.18% and 100.00% respectively,and the total cost were 265.26 yuans,1507.58 yuans and 1572.46 yuans,respectively. CONCLUSION The best pharmaco-therapeutic scheme was C.
OBJECTIVE To evaluate the economic effectiveness in different pharmaco-therapeutic schemes for patients with stress ulcer. METHODS 119 patients with stress ulcer were divided into 3 groups randomly. They received respectively one of three therapeutic shemes, A:aminomethylbenzoic acid combined with cimetidine, B:san-dostatin,C:omeprazole combined with thrombin, The date were evaluatde with cost-effectiveness analysis. RESULTS The effective ratio of three therapeutic shemes were 59.46%,87.18% and 100.00% respectively,and the total cost were 265.26 yuans,1507.58 yuans and 1572.46 yuans,respectively. CONCLUSION The best pharmaco-therapeutic scheme was C.
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