留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码
x 关闭 永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

珊瑚共附生真菌次级代谢产物研究进展

王洪亮,  张文

downloadPDF
文章导航 > 药学实践与服务  > 2019 >  37(3): 193-200,253
王洪亮, 张文. 珊瑚共附生真菌次级代谢产物研究进展[J]. 药学实践与服务, 2019, 37(3): 193-200,253. doi: 10.3969/j.issn.1006-0111.2019.03.001
引用本文: 王洪亮, 张文. 珊瑚共附生真菌次级代谢产物研究进展[J]. 药学实践与服务, 2019, 37(3): 193-200,253. doi: 10.3969/j.issn.1006-0111.2019.03.001
shu
WANG Hongliang, ZHANG Wen. Advances in secondary metabolites of coral epiphytic fungi[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 193-200,253. doi: 10.3969/j.issn.1006-0111.2019.03.001
Citation: WANG Hongliang, ZHANG Wen. Advances in secondary metabolites of coral epiphytic fungi[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 193-200,253. doi: 10.3969/j.issn.1006-0111.2019.03.001
shu

珊瑚共附生真菌次级代谢产物研究进展

doi: 10.3969/j.issn.1006-0111.2019.03.001
  • 1.

    海军军医大学药学院 上海 200433;陆军军医大学士官学校 河北 石家庄 050000

  • 2.

    海军军医大学药学院 上海 200433

基金项目: 国家自然科学基金（41576157）

Advances in secondary metabolites of coral epiphytic fungi

  • 1.

    School of Pharmacy, Naval Medical University, Shanghai 200433, China;Sergeant School of Army Medical College, Shijiazhuang 050000, China

  • 2.

    School of Pharmacy, Naval Medical University, Shanghai 200433, China

  • 摘要: 近年来，珊瑚共附生真菌化学成分研究受到越来越多的关注，截至2014年底，已经从38种珊瑚中分离共附生真菌95种，涉及44个属，从中分离得到化合物200余个，这些化合物表现出抗肿瘤、抗真菌、抗炎和抗污等生物活性。珊瑚共附生真菌来源的新化合物数量呈逐年上升趋势，仅4年时间就发现化合物近百个，这些化合物显示出不同的生物活性。从化学结构和生物活性两个方面综述近4年对珊瑚共附生真菌次级代谢产物的研究进展，以期为进一步的深入研究提供参考。
    Abstract: More and more attentions had been paid to the chemical constituents of epiphytic fungi in coral.By the end of 2014,95 species of epiphytic fungi,involving 44 genera,were isolated from 38 coral species.More than 200 compounds were isolated from them.These compounds exhibited anti-tumor,anti-fungal,anti-inflammatory and anti-fouling biological activities.In recent years,the number of new compounds from coral epiphytic fungi had been increasing year by year,and nearly 100 compounds had been found in recent four years.These structures showed different biological activities.The progress on secondary metabolites of coral symbiotic epiphytic fungi in recent four years was reviewed from the aspects of chemical structure and biological activity,which could provide reference for further study.
  • [1] KELECOM A.Secondary metabolites from marine microorganisms[J].An Acad Bras Cienc,2002,74(1):151-170.
    [2] RATEB M E,EBEL R.Secondary metabolites of fungi from marine habitats[J].Nat Prod Rep,2011,28(2):290-344.
    [3] SALEEM M,ALI M S,HUSSAIN S,et al.Marine natural products of fungal origin[J].Nat Prod Rep,2007,24(5):1142-1152.
    [4] HOU X M,XU R F,GU Y C,et al.Biological and chemical diversity of coral-derived microorganisms[J].Curr Med Chem,2015,22(32):3707-3762.
    [5] FRIEDRICH A B,MERKERT H,FENDERT T,et al.Microbial diversity in the marine sponge Aplysinacavernicola (formerly Verongia cavernicola) analyzed by fluorescence in situ hybridization (FISH)[J].Mar Biol,1999,134(3):461-470.
    [6] TAPIOLAS D M,ROMAN M,FENICAL W,et al.Octalactins A and B:cytotoxic eight-membered-ring lactones from a marine bacterium Streptomyces sp[J].J Ame Chem Soc,1991,113(113):4682-4683.
    [7] BLUNT J W,COPP B R,KEYZERS R A,et al.Marine natural products.[J].Nat Prod Rep,2018,35(1):8-53.
    [8] HILL A M.The biosynthesis,molecular genetics and enzymology of the polyketide-derived metabolites[J].Nat Prod Rep,2006,23(2):256-320.
    [9] SHI T,HOU X M,LI Z Y,et al.Harzianumnones A and B:two hydroxyanthraquinones from the coral-derived fungus Trichoderma harzianum[J].RSC Advances,2018,8(49):27596-27601.
    [10] WANG W Y,LIAO Y Y,TANG C,et al.Cytotoxic and antibacterial compounds from the coral-derived fungus Aspergillus tritici SP2-8-1[J].Mar Drugs,2017,15(11):348.
    [11] SUN Y Z,KURTÁN T,MÁNDI A,et al.Immunomodulatory polyketides from a phoma-like fungus isolated from a soft coral[J].J Nat Prod,2017,80(11):2930-2940.
    [12] LIU M T,ZHOU Q,et al.Anti-inflammatory butenolide derivatives from the coral-derived fungus Aspergillus terreus and structure revisions of aspernolides D and G,butyrolactone Ⅵ and 4',8″-diacetoxy butyrolactone Ⅵ[J].J Ame Chem Soc,2018,8:13040.
    [13] ZHU M,GAO H,WU C,et al.Lipid-lowering polyketides from a soft coral-derived fungus Cladosporium sp.TZP29[J].Bioorg Med Chem Lett,2015,25(17):3606-3609.
    [14] MA J,ZHANG X L,WANG Y,et al.Aspergivones A and B,two new flavones isolated from a gorgonian-derived Aspergillus candidus fungus[J].Nat Prod Res,2017,31(1):32-36.
    [15] ZHENG C J,SHAO C L,CHEN M,et al.Merosesquiterpenoids and ten-membered macrolides from a soft coral-derived Lophiostoma sp.fungus[J].Chem Biodivers,2015,12(9):1407-1414.
    [16] ELNAGGAR M S,EBADA S S,ASHOUR M L,et al.Two new triterpenoids and a new naphthoquinone derivative isolated from a hard coral-derived fungus Scopulariopsis sp.[J].Fitoterapia,2017,116:126-130.
    [17] ELNAGGAR M S,EBADA S S,ASHOUR M L,et al.Xanthones and sesquiterpene derivatives from a marine-derived fungus Scopulariopsis sp.[J].Tetrahedron,2016,72(19):2411-2419.
    [18] ZHENG C J,FU X M,ZHANG X L,et al.Bioactive perylene derivatives from asoft coral-derived fungus Alternaria sp.(ZJ-2008017)[J].Chem Nat Compd,2015,51(4):766-768.
    [19] KIM J W,KO S K,KIM H M,et al.Stachybotrysin,an osteoclast differentiation inhibitor from the marine-derived fungus Stachybotrys sp.KCB13F013[J].J Nat Prod,2016,79(10):2703-2708.
    [20] YANG B Y,SUN W G,WANG J P,et al.A new breviane spiroditerpenoid from the marine-derived fungus Penicillium sp.TJ403-1[J].Mar Drugs,2018,16(4):110-119
    [21] KOCHANOWSKA-KARAMYAN A J,HAMANN M T.Marine indole alkaloids:potential new drug leads for the control of depression and anxiety[J].Chem Rev,2010,110(8):4489-4497.
    [22] 郭娜燕,吕国荣,邱丹缨.海洋来源放线菌中新生物碱成分研究进展[J].天然产物研究与开发,2017,29(1):159-171.
    [23] NETZ N,OPATZ T.Marine indole alkaloids[J].Mar Drugs,2015,13(8):4814-4914.
    [24] LIU W,LI H J,XU M Y,et al.ChemInform abstract:pseudellones A-C,three alkaloids from the marine-derived fungus Pseudallescheria ellipsoidea F42-3.[J].ChemInform,2016,47(12):5156-5159.
    [25] WANG K T,XU M Y,LIU W,et al.Two additional new compounds from the marine-derived fungus Pseudallescheria ellipsoidea F42-3[J].Molecules,2016,21(4):442.
    [26] SHAO C L,XU R F,WANG C Y,et al.Potent Antifouling marine dihydroquinolin-2(1H)-one-containing alkaloids from the gorgonian coral-derived fungus Scopulariopsis sp[J].Mar Biotechnol,2015,17(4):408-415.
    [27] 管华诗,韩玉谦,冯晓梅.海洋活性多肽的研究进展[J].中国海洋大学学报(自然科学版),2004,34(5):761-766.
    [28] DAI Y,LIN Y,PANG X Y,et al.Peptides from the soft coral-associated fungus Simplicillium sp.SCSIO41209[J].Phytochemistry,2018,154:56-62.
    [29] MA X,NONG X H,REN Z,et al.Antiviral peptides from marine gorgonian-derived fungus Aspergillus sp.SCSIO 41501[J].Tetrahedron Lett,2017,58(12):1151-1155.
    [30] 崔承彬.激活海洋真菌中沉默次级代谢产物的实验技术新方法探索[C]//2014年中国药学大会暨第十四届中国药师周论文集.石家庄,2014:82.
    [31] REEN F J,ROMANO S,DOBSON A D,et al.The sound of silence:activating silent biosynthetic gene clusters in marine microorganisms[J].Mar Drugs,2015,13(8):4754-4783.
  • [1] 毛智毅, 王筱燕, 陈晓颖, 汤逸斐.  度拉糖肽联合二甲双胍对肥胖型2型糖尿病患者机体代谢、体脂成分及血清脂肪因子的影响 . 药学实践与服务, 2024, 42(7): 305-309. doi: 10.12206/j.issn.2097-2024.202305032
    [2] 孙丹倪, 黄勇, 张嘉宝, 王培.  代谢相关脂肪性肝病的无创诊断与药物治疗 . 药学实践与服务, 2024, 42(10): 411-418. doi: 10.12206/j.issn.2097-2024.202403049
    [3] 陈静, 何瑞华, 翁月, 徐熠, 刘静, 黄瑾.  基于网络药理学和分子对接技术探究定清片活性成分治疗白血病的作用机制 . 药学实践与服务, 2024, 42(11): 479-486. doi: 10.12206/j.issn.2097-2024.202401073
    [4] 景凯, 杨慈荣, 张圳, 臧艺蓓, 刘霞.  黄芪甲苷衍生物治疗慢性心力衰竭小鼠的药效评价及作用机制研究 . 药学实践与服务, 2024, 42(5): 190-197. doi: 10.12206/j.issn.2097-2024.202310004
    [5] 赖立勇, 夏天爽, 徐圣焱, 蒋益萍, 岳小强, 辛海量.  中药青蒿抗氧化活性的谱效关系研究 . 药学实践与服务, 2024, 42(5): 203-210, 216. doi: 10.12206/j.issn.2097-2024.202211012
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  3246
  • HTML全文浏览量:  493
  • PDF下载量:  487
  • 被引次数: 0
出版历程
  • 收稿日期:  2018-10-02
  • 修回日期:  2019-03-04

珊瑚共附生真菌次级代谢产物研究进展

doi: 10.3969/j.issn.1006-0111.2019.03.001
  • 1. 海军军医大学药学院 上海 200433;陆军军医大学士官学校 河北 石家庄 050000
  • 2. 海军军医大学药学院 上海 200433
    • 基金项目:  国家自然科学基金（41576157）
  • 收稿日期: 2018-10-02
  • 修回日期: 2019-03-04

摘要: 近年来，珊瑚共附生真菌化学成分研究受到越来越多的关注，截至2014年底，已经从38种珊瑚中分离共附生真菌95种，涉及44个属，从中分离得到化合物200余个，这些化合物表现出抗肿瘤、抗真菌、抗炎和抗污等生物活性。珊瑚共附生真菌来源的新化合物数量呈逐年上升趋势，仅4年时间就发现化合物近百个，这些化合物显示出不同的生物活性。从化学结构和生物活性两个方面综述近4年对珊瑚共附生真菌次级代谢产物的研究进展，以期为进一步的深入研究提供参考。

English Abstract

王洪亮, 张文. 珊瑚共附生真菌次级代谢产物研究进展[J]. 药学实践与服务, 2019, 37(3): 193-200,253. doi: 10.3969/j.issn.1006-0111.2019.03.001
引用本文: 王洪亮, 张文. 珊瑚共附生真菌次级代谢产物研究进展[J]. 药学实践与服务, 2019, 37(3): 193-200,253. doi: 10.3969/j.issn.1006-0111.2019.03.001
shu
WANG Hongliang, ZHANG Wen. Advances in secondary metabolites of coral epiphytic fungi[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 193-200,253. doi: 10.3969/j.issn.1006-0111.2019.03.001
Citation: WANG Hongliang, ZHANG Wen. Advances in secondary metabolites of coral epiphytic fungi[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 193-200,253. doi: 10.3969/j.issn.1006-0111.2019.03.001
shu

    全文HTML

参考文献 (31)

目录

    /

    返回文章
    返回

    版权所有：《药学实践与服务》编辑委员会

    主管、主办: 中国人民解放军海军军医大学地址: 上海市杨浦区国和路325号邮政编码: 200433

    电话: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    本系统由 北京仁和汇智信息技术有限公司 开发    百度统计