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白色念珠菌TOR信号转导通路研究现状

梁华军,  阎澜,  曹永兵,  姜远英,  颜天华

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文章导航 > 药学实践与服务  > 2014 >  32(4): 246-249,287
梁华军, 阎澜, 曹永兵, 姜远英, 颜天华. 白色念珠菌TOR信号转导通路研究现状[J]. 药学实践与服务, 2014, 32(4): 246-249,287. doi: 10.3969/j.issn.1006-0111.2014.04.002
引用本文: 梁华军, 阎澜, 曹永兵, 姜远英, 颜天华. 白色念珠菌TOR信号转导通路研究现状[J]. 药学实践与服务, 2014, 32(4): 246-249,287. doi: 10.3969/j.issn.1006-0111.2014.04.002
shu
LIANG Huajun, YAN Lan, CAO Yongbing, JIANG Yuanying, YAN Tianhua. Advances in TOR pathway in Candida albicans[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 246-249,287. doi: 10.3969/j.issn.1006-0111.2014.04.002
Citation: LIANG Huajun, YAN Lan, CAO Yongbing, JIANG Yuanying, YAN Tianhua. Advances in TOR pathway in Candida albicans[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 246-249,287. doi: 10.3969/j.issn.1006-0111.2014.04.002
shu

白色念珠菌TOR信号转导通路研究现状

doi: 10.3969/j.issn.1006-0111.2014.04.002
  • 1.

    中国药科大学药学院, 江苏 南京 210009

  • 2.

    第二军医大学药学院新药研究中心, 上海 200433

基金项目: 国家973项目(2013CB531602);国家自然科学基金资助项目(31000079);上海市基础研究重点项目(14JC1417500).

Advances in TOR pathway in Candida albicans

  • 1.

    School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China

  • 2.

    Center for New Drug Research, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 摘要: 雷帕霉素靶(target of rapamycin,TOR)蛋白是真核细胞生长的关键调控因子,是一类进化上保守的丝氨酸/苏氨酸(Ser/Thr)蛋白激酶,属于磷脂酰肌醇相关激酶(phosphatidylinositol kinase-related kinases, PIKKs)家族。TOR信号通路通过参与调节翻译的起始和延伸,核糖体生成,蛋白质生物合成,氨基酸转运,以及多种代谢酶的转运而使细胞对外界环境刺激产生应答。在此对人类条件性致病菌白色念珠菌TOR信号通路的研究现状作一综述。
    Abstract: The target of rapamycin (TOR), a Ser/Thr protein kinase of PIKKs (phosphatidylinositol kinase-related kinases), is the central factor of a highly conserved signaling pathway in eukaryotes, and regulates cell growth in response to nutrients, hormones, and stresses.It controls temporal growth by activating anabolic processes such as translation, ribosome biogenesis, protein synthesis, transportation of amino acid and metabolic enzymes.The advances in TOR pathway in the most pervasive human fungal pathogen Candida albicans.
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    [15] Tsao CC, Chen YT, Lan CY. A small G protein Rhb1 and a GTP ase-activating protein Tsc2 involved in nitrogen starvation-induced morphogenesis and cell wall integrity of Candida albicans[J]. Fungal Genet Biol, 2009, 46(2): 126-136.
    [16] Zacchi LF, Gomez-Raja J, Davis DA. Mds3 regulates morphogenesis in Candida albicans through the TOR pathway[J]. Mol Cell Biol, 2010, 30(14): 3695-3710.
    [17] Lee CM, Nantel A, Jiang LH, et al. The serine/threonine protein phosphatase SIT4 modulates yeast-to-hypha morphogenesis and virulence in Candida albicans[J]. Mol Microbol, 2004, 51(3): 691-709.
    [18] Liao WL, RamÓn AM, Fonzi WA. GLN3 encodes a global regulator of nitrogen metabolism and virulence of Candida albicans[J]. Fungal Genet Biol, 2008, 45(4): 514-526.
    [19] Huber A, Bodenmiller B, Uotila A, et al. Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis[J]. Genes Dev, 2009, 23: 1929-1943.
    [20] Liu W, Zhao JW, Li XC, et al. The protein kinase CaSch9p is required for the cell growth, filamentation and virulence in the human fungal pathogen Candida albica[J]. FEMS Yeast Res, 2010, 10(4): 462-470.
    [21] Li H, Tsang CK, Watkins M, et al. Nutrient regulates Tor1 nuclear localization and association with rDNA promoter[J]. Nature, 2006, 442: 1058-1061.
    [22] Strugill TW, Cohen A, Diefenbacher M, et al. TOR1 and TOR2 have distinct locations in live cells[J]. Eukaryot Cell, 2008, 7(10): 1819-1830.
    [23] Kim JE, Chen J. Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation[J]. PNAS, 2000, 97(26):14340-14345.
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    [25] Bastidas RJ, Heitman J, Cardenas ME. The protein kinase Tor1 regulates adhesin gene expression in Candida albicans[J]. PLoS Pathol, 2009, 5(2): e1000294.
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    [28] Lempiäinen H, Uotila A, Urban J, et al. Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling[J]. Mol Cell, 2009, 33(6): 704-716.
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    [32] Pedruzzi I, Dubouloz F, Cameroni E, et al. TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0 [J]. Mol Cell, 2003, 12(6): 1607-1613.
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  • 收稿日期:  2013-01-23
  • 修回日期:  2013-05-20

白色念珠菌TOR信号转导通路研究现状

doi: 10.3969/j.issn.1006-0111.2014.04.002
  • 1. 中国药科大学药学院, 江苏 南京 210009
  • 2. 第二军医大学药学院新药研究中心, 上海 200433
    • 基金项目:  国家973项目(2013CB531602);国家自然科学基金资助项目(31000079);上海市基础研究重点项目(14JC1417500).
  • 收稿日期: 2013-01-23
  • 修回日期: 2013-05-20

摘要: 雷帕霉素靶(target of rapamycin,TOR)蛋白是真核细胞生长的关键调控因子,是一类进化上保守的丝氨酸/苏氨酸(Ser/Thr)蛋白激酶,属于磷脂酰肌醇相关激酶(phosphatidylinositol kinase-related kinases, PIKKs)家族。TOR信号通路通过参与调节翻译的起始和延伸,核糖体生成,蛋白质生物合成,氨基酸转运,以及多种代谢酶的转运而使细胞对外界环境刺激产生应答。在此对人类条件性致病菌白色念珠菌TOR信号通路的研究现状作一综述。

English Abstract

梁华军, 阎澜, 曹永兵, 姜远英, 颜天华. 白色念珠菌TOR信号转导通路研究现状[J]. 药学实践与服务, 2014, 32(4): 246-249,287. doi: 10.3969/j.issn.1006-0111.2014.04.002
引用本文: 梁华军, 阎澜, 曹永兵, 姜远英, 颜天华. 白色念珠菌TOR信号转导通路研究现状[J]. 药学实践与服务, 2014, 32(4): 246-249,287. doi: 10.3969/j.issn.1006-0111.2014.04.002
shu
LIANG Huajun, YAN Lan, CAO Yongbing, JIANG Yuanying, YAN Tianhua. Advances in TOR pathway in Candida albicans[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 246-249,287. doi: 10.3969/j.issn.1006-0111.2014.04.002
Citation: LIANG Huajun, YAN Lan, CAO Yongbing, JIANG Yuanying, YAN Tianhua. Advances in TOR pathway in Candida albicans[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(4): 246-249,287. doi: 10.3969/j.issn.1006-0111.2014.04.002
shu

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