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微针透皮给药系统应用研究进展

万展,  周剑,  韩美娜,  杨峰

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文章导航 > 药学实践与服务  > 2012 >  30(2): 86-88,142
万展, 周剑, 韩美娜, 杨峰. 微针透皮给药系统应用研究进展[J]. 药学实践与服务, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
引用本文: 万展, 周剑, 韩美娜, 杨峰. 微针透皮给药系统应用研究进展[J]. 药学实践与服务, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
shu
WAN Zhan, ZHOU Jian, HAN Mei-na, YANG Feng. Progress on micro-needles transdermal drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
Citation: WAN Zhan, ZHOU Jian, HAN Mei-na, YANG Feng. Progress on micro-needles transdermal drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
shu

微针透皮给药系统应用研究进展

doi: 10.3969/j.issn.1006-0111.2012.02.002
  • 1.

    河北北方学院基础医学院, 河北 张家口 075000;第二军医大学药学院, 上海 200433

  • 2.

    重庆医科大学药学院, 重庆 400331;第二军医大学药学院, 上海 200433

  • 3.

    第二军医大学药学院, 上海 200433

基金项目: 上海高校选拔培养优秀青年教师科研专项基金(egd09014).

Progress on micro-needles transdermal drug delivery system

  • 1.

    School of Basic Medical Sciences, Hebei North University, Zhangjiakou 075000, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 2.

    School of Pharmacy, Chongqing Medical University, Chongqing 400331, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 3.

    School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 摘要: 微针透皮给药系统是近年来透皮给药系统研究的热点。微针透皮给药系统具有注射给药和透皮给药的双重优势,具有快速、方便、无痛等众多优点,研究表明可以显著提高药物透皮速率和吸收量,特别是在蛋白质、多肽、DNA和RNA等大分子物质的透皮制剂研究领域表现出良好的效果和应用前景,本文对微针透皮给药系统应用研究的最新进展进行了综述。随着微针加工技术、载药技术和应用研究的不断深入,微针透皮技术在临床领域将会有更广泛的应用。
    Abstract: Micro-needles transdermal drug delivery system became the hot spot in the field of transdermal drug delivery system, which had the double advantages in both injection drug delivery and transdermal drug delivery. It also had the merits of fast absorption, continence and painless utility in clinical. Research indicated both transdermal speed and dose of drugs were highly increased when micro-needles transdermal drug delivery system was applied, which especially showed outstanding effects and promise in the preparation of drugs composed of protein, polypeptide, DNA and RNA, etc. Latest developments of micro-needles transdermal drug delivery system were reviewed in this paper. With the development of the industrial arts of the micro-needle, drug delivery technology and application research, micro-needles transdermal drug delivery system would be extensively employed in clinical field.
  • [1] Henry S, McAllister DV, Allen MG, et al. Microfabricated microneedles : a novel approach to transdermal drug delivery[J]. J Pharmacol Sci,1998,87(8):922.
    [2] Mark RP, Robert L. Transdermal drug delivery[J].Nat Biotechnol,2008,26(11):1261.
    [3] Kalluri H, Banga AK. Transdermal delivery of proteins[J]. AAPS Pharmscitech, 2011.12(1):431.
    [4] Zhu QY,Zarnitsyn VG,Ye L,et al.Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge[J].Proc Natl Acad Sci USA,2009,106(19):7968.
    [5] Kaushik S, Hord AH, Denson DD, et al. Lack of pain associated with microfabricated microneedles[J]. Anesth.Analg,2001,92(2):502.
    [6] Ding Z,Riet V,Romeijn S,et al.Immune modulation by adjuvants combined with diphtheria toxoid administered topically in BALB／c mice after microneedle array pretreatment [J].Pharm Res,2009,26(7):163.
    [7] Sullivan SP, Koutsonanos DG,Del Pilar Martin M, et al.Dissolving polymer microneedle patches for influenza vaccination[J].Nat Med,2010,16(8):915.
    [8] Quan FS,Kim YC, Compans RW,et al. Dose sparing enabled by skin immunization with influenza virus-like particle vaccine using microneedles[J].J Controlled Release,2010,147(3):326.
    [9] Hiraishi Y,Nandakumar S,Choi SO,et al.Bacillus Calmette-Guerin vaccination using a microneedle patch[J].Vaccine,2011,29(14):2626.
    [10] Nordquist L,Roxhed N,Griss P,et al.ovel microneedle patches for active insulin delivery are efficientin maintaining glycaemic control:an initial comparison with ubcutaneous administration[J].Pharm Res,2007,24(7):1381.
    [11] Chen HB, Zhu HD,Zheng JN,et al. Iontophoresis-driven penetration of nanovesicles through microneedle induced skin microchannels for enhancing transdermal delivery of insulin[J]. J Controlled Release,2009,139(1):63.
    [12] Gupta J,Felner EI,Prausnitz MR.Rapid pharmacokinetics of intradermal insulin administered using microneedles in type 1 diabetes subjects[J].Diabetes Technol Ther,2011 13(4):451.
    [13] You X,Chang Jong-hyeon,Ju Byeong-Kwon,et al.Rapidly dissolving fibroin microneedles for transdermal drug delivery[J]. Mater Sci Eng.,C 2011,31(8):1632.
    [14] Qin G, Gao Y, Wu Y,et al.Simultaneous basal-bolus delivery of fast-acting insulin and its significance in diabetes management[J].Nanomedicine:NBM 2011,doi: 10.1016/j.nano.2011.05.017.
    [15] Harvey AJ,Kaestner SA,Sutter DE,et al.Microneedle-based intradermal delivery enables rapid lymphatic uptake and distribution of protein drugs[J].Pharm Res,2011,28(1):107.
    [16] Pearton M, Allender C, Brain K,et al.Gene delivery to the epidermal cells of human skin explants using microfabricated microneedles and hydrogel formulations[J]. Pharm Res,2008,25(2):407.
    [17] Gill HS, Soderholm J,Prausnitz MR,et al.Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine[J]. Gene Ther,2010,17(6):811.
    [18] Chen X,Kask AS,Crichton ML,et al.Improved DNA vaccination by skin-targeted delivery using dry-coated densely-packed microprojection arrays[J].J Controlled Release,2010,148(3):321.
    [19] Kask AS,Chen X,Marshak JO,et al.DNA vaccine delivery by densely-packed and short microprojection arrays to skin protects against vaginal HSV-2 challenge[J].Vaccine,2010,28(47):7483.
    [20] Gonzalez-Gonzalez E, Speaker TJ,Hickerson RP,et al.Silencing of reporter gene expression in skin using siRNAs and Expression of plasmid DNA delivered by a soluble protrusion array device[J]. Mol Ther,2010,18(9):1667.
    [21] Donnelly RF,Morrow DI,Fay F,et al.Microneedle-mediated intradermal nanoparticle delivery:potential for enhanced local administration of hydrophobic pre-formed photosensitisers[J].Photodiagnosis Photodyn Ther,2010,7(4):222.
    [22] Ito Y,Murano H,Hamasaki N,et al.Incidence of low bioavailability of leuprolide acetate after percutaneous administration to rats by dissolving microneedles[J].Int J Pharm,2011,407(1-2):126.
    [23] Baek C,Han M,Min J,et al.Local transdermal delivery of phenylephine to the anal sphincter muscle using microneedles[J].J Controlled Release,2011,154(2):138.
    [24] Milewski M,Yerramreddy TR,Ghosh P,et al.In vitro permeation of apegylated naltrexone prodrug across microneedle-treated skin[J].J Controlled Release,2010,146(1):37.
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出版历程
  • 收稿日期:  2011-09-01
  • 修回日期:  2011-12-06

微针透皮给药系统应用研究进展

doi: 10.3969/j.issn.1006-0111.2012.02.002
  • 1. 河北北方学院基础医学院, 河北 张家口 075000;第二军医大学药学院, 上海 200433
  • 2. 重庆医科大学药学院, 重庆 400331;第二军医大学药学院, 上海 200433
  • 3. 第二军医大学药学院, 上海 200433
    • 基金项目:  上海高校选拔培养优秀青年教师科研专项基金(egd09014).
  • 收稿日期: 2011-09-01
  • 修回日期: 2011-12-06

摘要: 微针透皮给药系统是近年来透皮给药系统研究的热点。微针透皮给药系统具有注射给药和透皮给药的双重优势,具有快速、方便、无痛等众多优点,研究表明可以显著提高药物透皮速率和吸收量,特别是在蛋白质、多肽、DNA和RNA等大分子物质的透皮制剂研究领域表现出良好的效果和应用前景,本文对微针透皮给药系统应用研究的最新进展进行了综述。随着微针加工技术、载药技术和应用研究的不断深入,微针透皮技术在临床领域将会有更广泛的应用。

English Abstract

万展, 周剑, 韩美娜, 杨峰. 微针透皮给药系统应用研究进展[J]. 药学实践与服务, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
引用本文: 万展, 周剑, 韩美娜, 杨峰. 微针透皮给药系统应用研究进展[J]. 药学实践与服务, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
shu
WAN Zhan, ZHOU Jian, HAN Mei-na, YANG Feng. Progress on micro-needles transdermal drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
Citation: WAN Zhan, ZHOU Jian, HAN Mei-na, YANG Feng. Progress on micro-needles transdermal drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
shu

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