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纤维化是一种由器官慢性损伤或炎症反应引起的病理变化,其主要特征是细胞外基质(ECM)的过度积累,可见于心、肺、肝、肾、皮肤等多种组织器官,纤维化持续进展可导致组织结构破坏及器官功能障碍,最终引起器官衰竭[1]。尽管各组织器官的纤维化发病机制不尽相同,但其基本过程大抵相似,由器官损伤引起炎症免疫反应,进而激活局部肌成纤维细胞,降低组织收缩力,促进炎症介质的分泌和ECM的合成,从而逐步发展为纤维化。重要脏器的纤维化严重影响人类的健康,是目前世界医学的研究难题。
隐丹参酮(CTS)是一种从唇形科植物丹参Salvia miltiorrhiza Bge的干燥根和根茎中提取的脂溶性二萜类蒽醌化合物,具有抗炎[2]、抗肿瘤[3]、抗菌[4]、神经保护[5]、心血管保护[6]等多种药理活性,近年来研究发现其还具有良好的抗组织纤维化作用[7-9]。目前研究显示,隐丹参酮的抗纤维化作用机制主要与信号转导和转录激活因子3(signal transduction and transcriptional activator 3, STAT3)、转化生长因子β(transforming growth factor-beta, TGFβ)和核因子κB(nuclear factor kappa-B, NF-κB)信号通路的抑制作用有关[7, 9,10]。本文主要就隐丹参酮对心、肺、肝、肾、皮肤等多种组织器官纤维化的治疗作用及其机制进行综述,为隐丹参酮的药物研究提供参考。
Research progress of cryptotanshinone on anti-fibrosis and its mechanism
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摘要: 隐丹参酮(CTS)作为一种高效低毒的天然化合物,在各器官组织中具有良好的抗纤维化作用,但目前其作用机制尚未明确,且无系统的文献综述对其抗纤维化潜在机制进行描述。笔者综述了隐丹参酮治疗各脏器纤维化的疗效及其机制,并提出了未来展望。Abstract: As a natural compound with high efficiency and low toxicity, cryptotanshinone (CTS) has a good anti-fibrosis effect in various organs and tissues. However, its mechanism of action has not been clearly defined, and there is no systematic literature review to describe its potential anti-fibrosis mechanism. The efficacy and mechanism of cryptotanshinone in the treatment of fibrosis in various organs were summarized and the use prospects were put forward in this paper.
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Key words:
- cryptotanshinone /
- renal fibrosis /
- pulmonary fibrosis /
- cardiac fibrosis /
- liver fibrosis /
- mechanism
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