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真菌多药耐药外排机制的研究进展

康烨 周密 阎澜

康烨, 周密, 阎澜. 真菌多药耐药外排机制的研究进展[J]. 药学实践与服务, 2016, 34(6): 485-488. doi: 10.3969/j.issn.1006-0111.2016.06.002
引用本文: 康烨, 周密, 阎澜. 真菌多药耐药外排机制的研究进展[J]. 药学实践与服务, 2016, 34(6): 485-488. doi: 10.3969/j.issn.1006-0111.2016.06.002
KANG Ye, ZHOU Mi, YAN Lan. Progress of the drug efflux mechanisms underlying fungi multidrug resistance[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 485-488. doi: 10.3969/j.issn.1006-0111.2016.06.002
Citation: KANG Ye, ZHOU Mi, YAN Lan. Progress of the drug efflux mechanisms underlying fungi multidrug resistance[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 485-488. doi: 10.3969/j.issn.1006-0111.2016.06.002

真菌多药耐药外排机制的研究进展

doi: 10.3969/j.issn.1006-0111.2016.06.002
基金项目: 国家自然科学基金面上项目(81470158)

Progress of the drug efflux mechanisms underlying fungi multidrug resistance

  • 摘要: 真菌多药耐药性是指真菌细胞对结构不同、作用靶点不同的药物同时具有耐药性的现象,是导致临床抗真菌治疗失败的重要原因之一。本文综述了酿酒酵母、条件致病真菌白假丝酵母、光滑假丝酵母和烟曲霉中多药耐药相关转运蛋白、药物外排机制以及基因表达调控网络的研究进展,旨在为深入了解真菌多药耐药性的机制、探讨克服多药耐药性的策略和提高抗真菌药物的药效提供参考。
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真菌多药耐药外排机制的研究进展

doi: 10.3969/j.issn.1006-0111.2016.06.002
    基金项目:  国家自然科学基金面上项目(81470158)

摘要: 真菌多药耐药性是指真菌细胞对结构不同、作用靶点不同的药物同时具有耐药性的现象,是导致临床抗真菌治疗失败的重要原因之一。本文综述了酿酒酵母、条件致病真菌白假丝酵母、光滑假丝酵母和烟曲霉中多药耐药相关转运蛋白、药物外排机制以及基因表达调控网络的研究进展,旨在为深入了解真菌多药耐药性的机制、探讨克服多药耐药性的策略和提高抗真菌药物的药效提供参考。

English Abstract

康烨, 周密, 阎澜. 真菌多药耐药外排机制的研究进展[J]. 药学实践与服务, 2016, 34(6): 485-488. doi: 10.3969/j.issn.1006-0111.2016.06.002
引用本文: 康烨, 周密, 阎澜. 真菌多药耐药外排机制的研究进展[J]. 药学实践与服务, 2016, 34(6): 485-488. doi: 10.3969/j.issn.1006-0111.2016.06.002
KANG Ye, ZHOU Mi, YAN Lan. Progress of the drug efflux mechanisms underlying fungi multidrug resistance[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 485-488. doi: 10.3969/j.issn.1006-0111.2016.06.002
Citation: KANG Ye, ZHOU Mi, YAN Lan. Progress of the drug efflux mechanisms underlying fungi multidrug resistance[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 485-488. doi: 10.3969/j.issn.1006-0111.2016.06.002
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