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2024 Vol. 42, No. 1

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Research progress on clinical application and quality control of sprays
ZHANG Yingnan, XU Ziyi, LU Guangzhao, LU Ying, ZHANG He
2024, 42(1): 1-5, 17. doi: 10.12206/j.issn.2097-2024.202306047
Abstract(7058) HTML (2690) PDF (1262KB)(57)
Abstract:
Sprays have gained significant attention and widespread use due to their numerous advantages, including rapid action, safety, and convenience. They are widely used in various fields such as dermatology, respiratory disease treatment, wound repair, an...
Progress on the relationship of aldehyde dehydrogenase 2 with human diseases and its small-molecule activators
SUN Xiangpei, GAO Xing, ZHAO Fengping, WANG Wentao, ZHANG Tianyi, TIAN Wei, ZHENG Canhui, CHEN Xin
2024, 42(1): 6-11. doi: 10.12206/j.issn.2097-2024.202302038
Abstract(6891) HTML (2369) PDF (1990KB)(90)
Abstract:
Aldehyde dehydrogenase 2 (ALDH2) is one of important factors against from the damage under oxidative stress in human body. A high proportion of East Asians carry ALDH2 inactive mutation gene. There are many diseases closely related to ALDH2, such as ...
Study on the stability and H+ permeable membrane properties of polymersomes
BIAN Kangqing, GUO Lingyi, CHI Wenya, YU Yuan
2024, 42(1): 12-17. doi: 10.12206/j.issn.2097-2024.202309010
Abstract(4392) HTML (1359) PDF (1658KB)(19)
Abstract:
Objective  To prepare polymersomes (PSs) by block copolymers, evaluate their membrane structural stability, investigate the H+ transmembrane permeability of PSs and the impact of 1,4-dioxane and establish a foundation for drug encapsulation within p...
Synthesis and biological activities of chlorin e6-based conjugate of fluorouracil as dual-mode antitumor photosensitizer
SHEN Jie, HUANG Fei, ZHANG Xingjie, YAO Jianzhong
2024, 42(1): 18-23. doi: 10.12206/j.issn.2097-2024.202306030
Abstract(3372) HTML (1392) PDF (2570KB)(72)
Abstract:
Objective  To design and synthesize the conjugate (compound 1 ) of chlorin e6 (compound 3 ) with fluorouracil (5-Fu) as novel pH-responsive dual-mode antitumor photosensitizer by acyl hydrazone bond coupling, based on literature reports that c...
Mechanism of Qizhenziyin mixture in the treatment of hypogonadism based on network pharmacology analysis and molecular docking
PAN Yujiong, HE Zhigao, CHEN Shixiu, ZHOU Gui, ZHOU Xin, YU Chao
2024, 42(1): 24-31. doi: 10.12206/j.issn.2097-2024.202208111
Abstract(4524) HTML (1761) PDF (3547KB)(38)
Abstract:
Objective  To investigate the mechanism of Qizhenziyin mixture in the treatment of hypogonadism by using the network pharmacology approach.   Methods  The active components of Qizhenziyin mixture were obtained by searching TCMSP , TCMID and HIT da...
Analysis on risk factors of clopidogrel resistance in patients with ischemic stroke
WANG Yajuan, ZHAO Yan, LI Weiliang, YU Airong
2024, 42(1): 32-37. doi: 10.12206/j.issn.2097-2024.202209054
Abstract(3941) HTML (1451) PDF (917KB)(24)
Abstract:
Objective  To investigate the risk factors of drug resistance in patients with ischemic stroke by clopidogrel therapy and provide references for promoting clinical individualized drug therapy.   Methods  A total of 202 inpatients diagnosed with is...
Analysis of 111 cases of aristolochic acids nephropathy
SHI Wenhui, WANG Yanmei, JIANG Li, LI Jun, LI Xiaomeng, HE Zhijun
2024, 42(1): 38-42. doi: 10.12206/j.issn.2097-2024.202308066
Abstract(3718) HTML (2141) PDF (1193KB)(25)
Abstract:
Objective   To analyze the clinical characteristics and regularity of aristolochic acid nephropathy (AAN) induced by drugs containing aristolochic acid.   Methods   The clinical data of 111 patients with AAN induced by aristolochic acid were revie...