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2023 Vol. 41, No. 6

Cover Catalogue
Reviews
Mitochondrial oxidative stress in vascular endothelial cell and atherosclerosis
WANG Daoxin, ZHANG Tianguang, MIAO Chaoyu
2023, 41(6): 329-334, 392. doi: 10.12206/j.issn.2097-2024.202205116
Abstract(6097) HTML (7728) PDF (1693KB)(79)
Abstract:
The injury of vascular endothelial cell function is the beginning of the pathological process of atherosclerosis. Mitochondrial oxidative stress is closely related to vascular endothelial cell function, which causes the dysfunction of vascular endoth...
Advances in the treatment of diabetic ulcers by Chinese herbal extracts
LU Hanzhi, WANG Yi, GUO Dongjie, GUO Wanjun, ZHU Jianyong, LI Fulun
2023, 41(6): 335-340, 357. doi: 10.12206/j.issn.2097-2024.202204111
Abstract(6100) HTML (3843) PDF (2401KB)(34)
Abstract:
Skin ulcers are the most prevalent consequence of diabetes mellitus, and people with diabetic ulcers have a substantially greater death risk than those who do not have ulcers. Herbal medications have gained wide concern in recent years due to their m...
Advances and prospects in targeted protein degradation
ZHOU Luozhu, SHENG Chunquan
2023, 41(6): 341-351, 365. doi: 10.12206/j.issn.2097-2024.202303008
Abstract(7698) HTML (9895) PDF (2184KB)(193)
Abstract:
Targeted protein degradation (TPD) techniques eliminate pathogenic proteins by hijacking the intracellular proteolysis machinery which includes the ubiquitin-proteasome system (UPS) and the lysosomal degradation pathway, holding promise to overcome t...
Research progress on drug combination therapy against Candida albicans
DENG Zhongyu, GUO Shijin, GUO Yifan, FENG Juncheng, LYU Quanzhen, QIU Lijuan
2023, 41(6): 352-357. doi: 10.12206/j.issn.2097-2024.202112019
Abstract(7450) HTML (2326) PDF (1028KB)(50)
Abstract:
Candida albicans is one of the most common species of Candida, which is an important cause of invasive candidiasis in clinic. Due to the frequently use of classical antifungal agents, there are amounts of drug resistant C. albicans being isolated, ca...
Original articles
In vivo pharmacokinetic study on determination of effective components in Xiakucao Xiaoliu mixture in Normal Rat Plasma By LC-MS/MS
DAI Yuanyuan, MA Minghua, XU Xiaohong, WANG Xiaohe, ZHANG Ruoxi, XU Zhiru, NIAN Hua
2023, 41(6): 358-365. doi: 10.12206/j.issn.2097-2024.202111008
Abstract(6628) HTML (2018) PDF (1776KB)(16)
Abstract:
Objective   To establish a method and study the pharmacokinetics for concentration determination of effective components in Xiakucao Xiaoliu mixture in Normal Rat Plasma By LC-MS/MS.   Methods  The mobile phase was methanol-water (0.1% formic acid...
Species differences of Baishouwu based on characteristic chromatogram and content determination of acetophenones
LIN Meiyu, CHEN Wenhua, XU Lingchuan, HAN Ting, SU Juan, ZHANG Chi
2023, 41(6): 366-371. doi: 10.12206/j.issn.2097-2024.202207036
Abstract(3898) HTML (1403) PDF (1556KB)(10)
Abstract:
Objectives   To provide scientific basis for the quality control of different species of Baishouwu by establishing the HPLC fingerprint of domestic of Baishouwu and determining the main active components of acetophenones.   Methods   HPLC-DAD meth...
Comparison of contents variation of six isoflavones in black beans, semifinished and finished Sojae Semen Praeparatum
JIANG Yuetong, GAO Congcong, ZHANG Yujia, OU Yangyu, ZHOU Tingting
2023, 41(6): 372-376. doi: 10.12206/j.issn.2097-2024.202209085
Abstract(4256) HTML (1757) PDF (1026KB)(25)
Abstract:
Objective  To compare the contents variation of six flavonoids includingdaidzin, glycitin, genistin, daidzein, glycitein and genisteinin black beans, semifinished and finished Sojae Semen Praeparatum.Methods The contents of flavonoids were determine...
Research reports
Data verification and sensitivity analysis of statistical analysis in bioequivalence studies
LI Linhe
2023, 41(6): 377-379. doi: 10.12206/j.issn.2097-2024.202212040
Abstract(4115) HTML (1792) PDF (896KB)(48)
Abstract:
Objective  To sort out the key points, problems and countermeasures of data verification through data verification of statistical analysis in 18 bioequivalence studies, and provide reference for improving the statistical analysis reports of related r...
Medicine & Clinical
Efficacy of Jiangsha Banxia nano-paste on nausea and vomiting in end-stage patients and its effect on QOL in cancer patients
ZHANG Tianhong, LIU Xiufeng, WANG Hua, DING Xiujuan, DAI Haimin, HU Ping, WANG Weifeng, LU Qing, XU Feng, HE Wanhong
2023, 41(6): 380-384. doi: 10.12206/j.issn.2097-2024.202210049
Abstract(3268) HTML (1632) PDF (913KB)(6)
Abstract:
Objective  To observe the clinical efficacy of Jiangshabanxia nano-paste on nausea and vomiting in end-stage patients and its effect on the quality-of-life (QOL) in cancer patients.   Methods  120 end-stage patients with nausea and vomiting symptoms ...
Establishment and application of DUE criteria of Dolasetron
ZHANG Min, GAO Ningzhou, ZHANG Yunxuan, ZHOU Haifeng
2023, 41(6): 385-388. doi: 10.12206/j.issn.2097-2024.202202026
Abstract(2456) HTML (1769) PDF (884KB)(16)
Abstract:
Objective   To establish the drug use evaluation ( DUE) of Dolasetron, evaluate the rationality of the clinical use of Dolasetron and provide a reference for the rationally clinical use of Dolasetron.  Methods  On the basis of Dolasetron DUE criteria...
Pharmacy administration
Design and application of auxiliary system for drug distribution in outpatient pharmacy
YANG Bin, LI Xin, WEI Ping, CHU Zheng
2023, 41(6): 389-392. doi: 10.12206/j.issn.2097-2024.202106003
Abstract(3296) HTML (2252) PDF (952KB)(27)
Abstract:
Objective   To construct the auxiliary system of outpatient drug distribution, reduce errors and improve the quality of outpatient pharmaceutical service.   Methods   The bar code technology was used to independently develop outpatient pharmacy dispe...