异甘草酸镁预防奥沙利铂肝损伤的临床观察

吕建峰; 刘华; 叶爱琴; 刘君; 丁荣杰

doi:10.3969/j.issn.1006-0111.2015.02.021

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异甘草酸镁预防奥沙利铂肝损伤的临床观察

吕建峰, 刘华, 叶爱琴, 刘君, 丁荣杰

文章导航 > 药学实践与服务 > 2015 > 33(2): 171-172

吕建峰, 刘华, 叶爱琴, 刘君, 丁荣杰. 异甘草酸镁预防奥沙利铂肝损伤的临床观察[J]. 药学实践与服务, 2015, 33(2): 171-172. doi: 10.3969/j.issn.1006-0111.2015.02.021

引用本文:

吕建峰, 刘华, 叶爱琴, 刘君, 丁荣杰. 异甘草酸镁预防奥沙利铂肝损伤的临床观察[J]. 药学实践与服务, 2015, 33(2): 171-172. doi: 10.3969/j.issn.1006-0111.2015.02.021

LÜ Jianfeng, LIU Hua, YE Aiqin, LIU Jun, DING Rongjie. Observation of glutathione to prevent oxaliplatin-induced hepatic lesion[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 171-172. doi: 10.3969/j.issn.1006-0111.2015.02.021

Citation:

LÜ Jianfeng, LIU Hua, YE Aiqin, LIU Jun, DING Rongjie. Observation of glutathione to prevent oxaliplatin-induced hepatic lesion[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 171-172. doi: 10.3969/j.issn.1006-0111.2015.02.021

异甘草酸镁预防奥沙利铂肝损伤的临床观察

doi: 10.3969/j.issn.1006-0111.2015.02.021

泰兴市人民医院, 江苏泰兴 225400

Observation of glutathione to prevent oxaliplatin-induced hepatic lesion

Taixing People's Hospital, Taixing 225400, China

摘要: 目的观察异甘草酸镁预防奥沙利铂致肝损伤的疗效。方法对照组采用奥沙利铂、亚叶酸钙、氟尿嘧啶方案化疗,治疗组采用奥沙利铂、亚叶酸钙、氟尿嘧啶方案化疗同时使用异甘草酸镁,以28 d为1个疗程,治疗周期为2~4个疗程,观察患者发生肝损伤的比例。结果对照组肝损伤发生率为44.4%,治疗组肝损伤发生率为19.4%,两组间有显著性差异(P<0.01)。结论异甘草酸镁可有效预防奥沙利铂所致的肝损伤,值得临床推广使用。
- 奥沙利铂 /
- 异甘草酸镁 /
- 肝损伤
Abstract: Objective To observe the curative effect of magnesium isoglycyrrhizinate in prevention of liver injury induced by oxaliplatin. Methods The control group used oxaliplatin, leucovorin, 5-fluorouracil chemotherapy, the treatment group were treated with oxaliplatin, leucovorin, 5-fluorouracil chemotherapy and simultaneous magnesium isoglycyrrhizinate were used at the same time. With 28 d for 1 course of treatment, the treatment period consisted of 2-4 courses, observation of patients and the proportion of liver injury were made. Results In the control group, liver injury incidence rate was 44.4%, the rate of injury was 19.4% in treatment group, there was significant difference between the two groups (P<0.01). Conclusion Magnesium isoglycyrrhizinate could be effective in prevention of oxaliplatin induced liver injury.
- oxalic acid platinum /
- magnesium isoglycyrrhizinate injection /
- liver function damage

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异甘草酸镁预防奥沙利铂肝损伤的临床观察

doi: 10.3969/j.issn.1006-0111.2015.02.021

泰兴市人民医院, 江苏泰兴 225400

收稿日期: 2013-12-10
修回日期: 2014-03-17

关键词:

奥沙利铂 /

异甘草酸镁 /

肝损伤

摘要: 目的观察异甘草酸镁预防奥沙利铂致肝损伤的疗效。方法对照组采用奥沙利铂、亚叶酸钙、氟尿嘧啶方案化疗,治疗组采用奥沙利铂、亚叶酸钙、氟尿嘧啶方案化疗同时使用异甘草酸镁,以28 d为1个疗程,治疗周期为2~4个疗程,观察患者发生肝损伤的比例。结果对照组肝损伤发生率为44.4%,治疗组肝损伤发生率为19.4%,两组间有显著性差异(P<0.01)。结论异甘草酸镁可有效预防奥沙利铂所致的肝损伤,值得临床推广使用。