Preparation of nicardipine hydrochloride sustained-release pellets
-
摘要: 目的 制备盐酸尼卡地平缓释微丸,并考察其体外释药的影响因素。 方法 采用底喷式流化床包衣法,以空白丸芯为基础制备速释微丸,乙基纤维素水分散体为包衣材料制备盐酸尼卡地平缓释微丸,考察其包衣处方及工艺的影响因素。 结果 所得缓释微丸在2、6、12 h的累积释药百分率分别为24%、69%、87%,体外释放曲线符合一级方程。 结论 制备的微丸缓释效果理想,且制备工艺简单,操作方便。Abstract: Objective To prepare nicardipine hydrochloride sustained-release pellets and investigate the influencing factors of the drug release in vitro. Methods The rapid-release pellets were prepared by fluidized bed coating method based on blank pill core and then nicardipine hydrochloride sustained-release pellets were prepared with surelease. The factors to influence the drug release behaviors and their properties were evaluated. Results The release percentage of the sustained-release pellets could be controlled by 24%, 69%, 87% at 2 h, 6 h, 12 h respectively, the drug release mechanism in vitro followed first-order equations. Conclusion The pellets showed an obviously sustained-release effect.The preparation process was simple and convenient.
-
Key words:
- nicardipine hydrochloride /
- surelease /
- sustained-release pellets /
- fluidized bed
-
[1] 陈新谦,金有豫,汤 光.新编药物学[M].第16版.北京:人民卫生出版社,2007:365. [2] 中国药典2010年版.二部[S]. 2010:附录87. [3] Costa P,Sousa LJM.Modeling and comparison of dissolution profiles[J].Eur J Pharm Sci,2001,13(2):123. [4] 张 强,武凤兰.药剂学[M].北京:北京大学医学出版社,2005:52. [5] 李 霞,刘晓军,马桂芝,等.盐酸曲马多缓释微丸的制备及处方工艺考察[J].解放军药学学报,2007,23(3):78.
计量
- 文章访问数: 2814
- HTML全文浏览量: 267
- PDF下载量: 513
- 被引次数: 0