Preparation and physical chemistry properties research of cholesterol succinyl Bletilla striata polysaccharide
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摘要: 目的 对白芨多糖疏水改性,并测其分子量和研究其理化性质。 方法 以白芨多糖为原料,合成胆甾醇琥珀酰基-白芨多糖;用红外光谱对结构进行表征;用高效凝胶渗透色谱法测分子量。 结果 合成了胆甾醇琥珀酰基白芨多糖;分子量为650 kDa;其理化性质:pH 6.89;黏度130 mPa·s;等电点 5.07;溶解度 0.9 g。 结论 合成方法可行,得率稳定,为进一步扩大试验提供了研究基础。Abstract: Objective To determination the molecular weight and studies on its properties after hydrophobic modification of Bletilla striata polysaccharide. Methods Bletilla striata polysaccharide were used as the starting materials, which reacted with cholesterol succinate to afford a derivate of cholesterol succinate polysaccharide, characterizate its structure by infrared spectroscopy, determinate its molecular weight by Sephadex chromatography(HPGPC). Results Acholesterol succinate polysaccharide was synthesized:molecular weight 650 kDa, pH 6.89, viscosity 130 mpa, isoelectric point 5.07, solubilit 0.9 g. Conclusion The method of synthesis was feasible and stable, which provided valuable research base for expand test.
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[1] 刘逢芹,夏丽娅.中药白芨的现代研究概况[J].山东医药工业,2000,19(5):32. [2] Wang QP,Zhang DH.The characters of Blelitta striata Reichb.f.and its potential potential developing vaines[J].Resecrce Development&Market,2000,16(4):216. [3] 江 倩,王银松. 新型两亲性小分子-N-胆甾醇基琥珀酰基氨基葡萄糖的合成及其自组装行为的初步研究[J].国际生物医学工程,2009,32(3):142. [4] 韩 笑,谭天伟.羧甲基壳聚糖制备新工艺研究[N].北京化工大学学报.2000,27(3):1. [5] Rong HC.Conformational changes of chitosan molecules and the shift of break point of Mark Houwink equation by increasing urea concentration[J].Appl Polym Sci,2000,75(4):452. [6] 中国药典2010年版二部[S].2010:附录42. [7] Skiyoshi K, Sunamoto J.Supramolecular assembly of hydrophobized polysaccharides[J].Supramol Sci,1996,3(4):157. -
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