阿魏酸钠滴丸的制备及溶出度测定
Studies on the preparation and dissolution of sodium ferulate dropping pill
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摘要: 目的： 通过固体分散技术制备滴丸, 以提高阿魏酸钠的溶出度。 方法： 以聚乙二醇(PEG)6000、泊洛沙姆188为载体基质制备滴丸, HPLC法测定含量, 转篮法考察溶出度。 结果： 滴丸中PEG 6000/药物比值越大, 阿魏酸钠溶出越快；所制得滴丸外观圆整, 质地均匀；分别以0．1mol/L盐酸溶液、水、pH 6．8磷酸盐缓冲液为溶出介质, 阿魏酸钠滴丸均较市售片显著增加溶出度。 结论： 阿魏酸钠滴丸具有良好的速释效果。Abstract: Objective: To improve the dissolution rate of sodium ferulate by preparing the dropping pill using the technology of solid dispersion. Methods: The dropping pill was prepared with PEG 6000 and poloxamer 188 as carriers.The dissolution rate of sodium fer-ulate was measured using the basket method as well as HPLC. Results: The higher the ratio of PEG 6000 vs sodium ferulate in the dropping pill was, the greater the dissolution rate of the drug was.The dropping pill prepared was rounded and homogeneous.With 0.1 mol/L hydrochloride solution, water and pH 6.8 phosphrate buffer solution as the media, the dissolution rate of sodium ferulate from dropping pill was significantly faster than that from the marketing tablet of sodium ferulate, respectively. Conclusion: Sodium ferulate dropping pill had excellent rapid release effect.
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Key words:
- sodium ferulate /
- dropping pill /
- dissolution
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