气管炎丸的药理学研究
Antitussive, expectorant and antiasthmatic actions of Qiguanyan pill
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摘要: 目的 研究气管炎丸的止咳、平喘、祛痰作用。方法 采用豚鼠离体气管法和拘橼酸引喘法观察气管炎丸的平喘作用;用雾化氨水刺激小鼠引咳法观察该药的镇咳作用;用小鼠酚红实验观察其祛痰作用。结果 该药可以有效地降低动物由氨水刺激引咳的咳嗽次数,可以明显延长豚鼠致喘的潜伏期,对乙酰胆碱及组胺造成的豚鼠离体气管平滑肌收缩有显著的拮抗作用,可以增加小鼠气管及支气管酚红的分泌量。结论 气管炎丸具有较好的止咳、平喘、祛痰效果。Abstract: Objective To study antitussive, expectorant and antiasthmatic actions of Qiguanye pill. Methods Histamine was used to induce tracheaspasm in whole body and Guinea pig's isolated trachea test was used to observe the antiasthmatic action Of Qiguanye pill. Phenol red test was used to observe its expectorant action in mice. The cough of animal was induced by ammonia water to trachea tract. Results Qiguanye pill could obviously prolong the incubation period of asthma produced by histamine and also could markedly reduce the contraction amplitude, induced by histamine and acetylcholine of isolated trachea of Guinea pig. The contraction amplitudes were reduced. It could markedly increase excretion of phenol red in the trachial cavity of mice and could obviously reduce cough times of felines and mice. Conclusion Qiguanye pill has good antitussive,expectorant and antiasthmatic actions.
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Key words:
- Qiguanye pill /
- Antiasthmatic action /
- Expectorant action /
- Antitussive
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