大承气汤改善家兔实验性肺水肿及多脏器损害的病理学研究
The pathological studies on Dachengqi decoction for treating experimental pulmonary edema in rabbits
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摘要: 目的 研究大承气汤改善阳明腑实喘满证中肺通气功能和肺组织病变的机制。方法 将家兔随机分为对照组(A)、治疗组(B)和大承气汤组(C)。从兔耳缘静脉注入油酸建立家兔实验性肺水肿的动物模型。大承气汤以胃管插入进行治疗,观察动物一般情况、血气分析及形态学改变等指标。结果 油酸可以致家兔实验性肺水肿,以肺水肿、肺出血、毛细血管微血栓和肺泡内透明膜形成为主要标志,同时伴多脏器损伤。大承气汤具有改善肺水肿、促进肺泡上皮增生特别是Ⅱ型上皮增生、保护多脏器功能,促进损伤修复的作用。结论 大承气汤的治疗作用可能与其促进水肿液的吸收、促进肺泡上皮增生特别是Ⅱ型上皮增生与修复、改善肺泡/通气血流比例、保护多脏器以及改善内环境等多种作用有关。Abstract: OBJECTIVE In order to investigate the mechanism of the action of Da-cheng-qi-decoction (DD) in treating acute pulmonary edema, Rabbit model of experimental pulmonary edema was made with injecting oleic acid (group B), and then treated with DD (group C). Randomly 10 cases of normal rabbit without any treatment were served as the normal control group (group A). RESULT:In group B, the important pathological changes are interstitial and intra-alveolar edema, hemorrhage, hyaline thrombus in small pulmonary venules and hyaline membranes in the alveolar lumina. DD show a effection of improving above pathological changes, promoting growth of pneumocyte espectialy pneumocyte Ⅱ, reducing multi-organs injury. These findings indicate that it may be its mainly mechanism in treating with acute pulmonary edema by eliminating exudation, enhancing the growth of pneu-mocyte Ⅱ, adjusting the balance of ventilation-perfusion, protecting organs from injury and so on.
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Key words:
- Da-cheng-qi-decoction(DT) /
- oleic acid /
- pulmonary edema /
- pneumocyte Ⅱ
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