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Volume 36 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2018  >  36(3): 247-249,254

GAO Yanxia, SU Juan, JIN Huizi. Study on HPLC fingerprint of Ginseng Radix et Rhizoma Rubra[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 249-251,254. doi: 10.3969/j.issn.1006-0111.2016.03.014
Citation: MA Huiping, WANG Xin, WU Ningzi, JING Linlin, JIA Zhengping, ZHANG Jun. Pharmacodynamics of the effective anti-hypoxia constituents in Saussurea involucrata[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 247-249,254. doi: 10.3969/j.issn.1006-0111.2018.03.012
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Pharmacodynamics of the effective anti-hypoxia constituents in Saussurea involucrata

doi: 10.3969/j.issn.1006-0111.2018.03.012

  • Lanzhou General Hospital Key Lab of PLA for Prevention and Treatment of Injuries induced by High Altitude, Lanzhou 730050, China

  • Received Date: 2017-11-08
  • Rev Recd Date: 2018-01-18
  • Objective To study pharmacodynamics of the effective anti-hypoxia components in the petroleum ether extract of Saussurea Involucrate (PESI) and octacosane. Methods PESI and octacosane were first evaluated by normobaric hypoxia model, acute decompression model and followed by chemical induced hypoxic models with potassium cyanide, sodium nitrite and isoprenaline hydrochloride poisoning. Results PESI and octacosane can effectively prolong the survival time of hypobaric hypoxic mice (P<0.01) and reduce the mortality of acute hypobaric hypoxia mice (P<0.01) in a dose-dependent manner. Anti-hypoxic potency of PESI and octacosane obtained by chemical induced hypoxic model indicated that they significantly increase survival time(P<0.05)of hypoxia mice than acetazolamide. Conclusion PESI and octacosane have good anti-hypoxia activity.
  • [1] 翟科峰,王聪,高贵珍,等.天山雪莲的研究进展.湖北农业科学,2009,48(11):2869-2873.
    [2] Jia JM,Wu CF,Liu W,et al.Antiinflammatory and analgesic activities of the tissue culture of Saussurea involucrata[J].BiolPharm Bull,2005,28(9):1612-1614.
    [3] Lee JC,Kao JY,Kuo DH,et al.Antifatigue and antioxidant activity of alcoholic extract from Saussurea involucrata[J].J Trad Compl Med,2011,1(1):64-68.
    [4] 马慧萍,焦阳,高荣敏,等.大苞雪莲乙醇提取物对模拟高原缺氧小鼠生化指标的影响[J].中药材,2014,37(1):99-103.
    [5] Ma HP,Fan PC,Jing LL,et al.Anti-hypoxic activity at simulated high altitude was isolated in petroleum ether extract of Saussurea involucrata[J].J Ethnopharmacol, 2011, 137(3):1510-1515.
    [6] 景临林,何蕾,樊鹏程,等.天山雪莲抗缺氧活性成分研究[J].中药材,2015,38(1):89-92.
    [7] 马慧萍,何蕾,王昕,等.藏紫菀总黄酮对模拟高原缺氧小鼠的保护作用[J].解放军医药杂志,2016,28(6):1-4.
    [8] 陈奇.中药药理研究方法学[M].北京:人民卫生出版社,2006:63-78.
    [9] 许福会,曾南,彭希,等.芳香开窍药对小鼠急性缺氧损伤的影响[J].中药药理与临床,2010,26(5):72-74.
    [10] 景临林,马慧萍,杨芳芳,等.新型双靶标化合物的合成与其抗高原缺氧损伤活性研究[J].解放军医药杂志, 2016,28(6):5-8,13.
    [11] 马慧萍,高荣敏,吴金华,等.大苞雪莲乙醇提取物对模拟高原缺氧小鼠物质代谢的影响[J].解放军药学学报,2013,29(4):279-282.
    [12] 蒋炜,樊鹏程,何蕾,等.天山雪莲乙醇提取物对缺氧小鼠肝脏线粒体的保护作用研究[J].中药材,2015,38(4):790-793.
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    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 20.2 %其他: 20.2 %China: 1.4 %China: 1.4 %India: 0.4 %India: 0.4 %上海: 2.8 %上海: 2.8 %东莞: 0.4 %东莞: 0.4 %临汾: 0.4 %临汾: 0.4 %乌鲁木齐: 0.2 %乌鲁木齐: 0.2 %信阳: 0.2 %信阳: 0.2 %北京: 11.9 %北京: 11.9 %南京: 0.2 %南京: 0.2 %南宁: 0.2 %南宁: 0.2 %南昌: 0.5 %南昌: 0.5 %南通: 0.2 %南通: 0.2 %台湾省: 0.2 %台湾省: 0.2 %合肥: 0.2 %合肥: 0.2 %咸阳: 0.5 %咸阳: 0.5 %唐山: 1.2 %唐山: 1.2 %大连: 0.9 %大连: 0.9 %天津: 0.4 %天津: 0.4 %孝感: 0.2 %孝感: 0.2 %安顺: 0.2 %安顺: 0.2 %广州: 0.9 %广州: 0.9 %张家口: 0.7 %张家口: 0.7 %惠州: 0.2 %惠州: 0.2 %成都: 0.7 %成都: 0.7 %无锡: 0.2 %无锡: 0.2 %昆明: 0.2 %昆明: 0.2 %杭州: 0.4 %杭州: 0.4 %梧州: 0.2 %梧州: 0.2 %武汉: 0.5 %武汉: 0.5 %洛阳: 0.2 %洛阳: 0.2 %济南: 0.2 %济南: 0.2 %深圳: 0.7 %深圳: 0.7 %漳州: 0.2 %漳州: 0.2 %濮阳: 0.2 %濮阳: 0.2 %盐城: 0.4 %盐城: 0.4 %石家庄: 0.5 %石家庄: 0.5 %聊城: 0.2 %聊城: 0.2 %芒廷维尤: 26.2 %芒廷维尤: 26.2 %芝加哥: 0.2 %芝加哥: 0.2 %苏州: 0.5 %苏州: 0.5 %菏泽: 0.2 %菏泽: 0.2 %西宁: 20.5 %西宁: 20.5 %西安: 0.2 %西安: 0.2 %赤峰: 0.4 %赤峰: 0.4 %运城: 0.9 %运城: 0.9 %郑州: 0.2 %郑州: 0.2 %长沙: 0.4 %长沙: 0.4 %长治: 0.5 %长治: 0.5 %黄冈: 0.9 %黄冈: 0.9 %黄冈市麻城: 0.2 %黄冈市麻城: 0.2 %其他ChinaIndia上海东莞临汾乌鲁木齐信阳北京南京南宁南昌南通台湾省合肥咸阳唐山大连天津孝感安顺广州张家口惠州成都无锡昆明杭州梧州武汉洛阳济南深圳漳州濮阳盐城石家庄聊城芒廷维尤芝加哥苏州菏泽西宁西安赤峰运城郑州长沙长治黄冈黄冈市麻城Highcharts.com
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Pharmacodynamics of the effective anti-hypoxia constituents in Saussurea involucrata

doi: 10.3969/j.issn.1006-0111.2018.03.012
  • Lanzhou General Hospital Key Lab of PLA for Prevention and Treatment of Injuries induced by High Altitude, Lanzhou 730050, China
  • Received Date: 2017-11-08
  • Rev Recd Date: 2018-01-18

Abstract: Objective To study pharmacodynamics of the effective anti-hypoxia components in the petroleum ether extract of Saussurea Involucrate (PESI) and octacosane. Methods PESI and octacosane were first evaluated by normobaric hypoxia model, acute decompression model and followed by chemical induced hypoxic models with potassium cyanide, sodium nitrite and isoprenaline hydrochloride poisoning. Results PESI and octacosane can effectively prolong the survival time of hypobaric hypoxic mice (P<0.01) and reduce the mortality of acute hypobaric hypoxia mice (P<0.01) in a dose-dependent manner. Anti-hypoxic potency of PESI and octacosane obtained by chemical induced hypoxic model indicated that they significantly increase survival time(P<0.05)of hypoxia mice than acetazolamide. Conclusion PESI and octacosane have good anti-hypoxia activity.

GAO Yanxia, SU Juan, JIN Huizi. Study on HPLC fingerprint of Ginseng Radix et Rhizoma Rubra[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 249-251,254. doi: 10.3969/j.issn.1006-0111.2016.03.014
Citation: MA Huiping, WANG Xin, WU Ningzi, JING Linlin, JIA Zhengping, ZHANG Jun. Pharmacodynamics of the effective anti-hypoxia constituents in Saussurea involucrata[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 247-249,254. doi: 10.3969/j.issn.1006-0111.2018.03.012
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