MA Huiping, WANG Xin, WU Ningzi, JING Linlin, JIA Zhengping, ZHANG Jun. Pharmacodynamics of the effective anti-hypoxia constituents in Saussurea involucrata[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 247-249,254. doi: 10.3969/j.issn.1006-0111.2018.03.012
| Citation:
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MA Huiping, WANG Xin, WU Ningzi, JING Linlin, JIA Zhengping, ZHANG Jun. Pharmacodynamics of the effective anti-hypoxia constituents in Saussurea involucrata[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 247-249,254. doi: 10.3969/j.issn.1006-0111.2018.03.012
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Pharmacodynamics of the effective anti-hypoxia constituents in Saussurea involucrata
- Received Date: 2017-11-08
- Rev Recd Date:
2018-01-18
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Abstract
Objective To study pharmacodynamics of the effective anti-hypoxia components in the petroleum ether extract of Saussurea Involucrate (PESI) and octacosane. Methods PESI and octacosane were first evaluated by normobaric hypoxia model, acute decompression model and followed by chemical induced hypoxic models with potassium cyanide, sodium nitrite and isoprenaline hydrochloride poisoning. Results PESI and octacosane can effectively prolong the survival time of hypobaric hypoxic mice (P<0.01) and reduce the mortality of acute hypobaric hypoxia mice (P<0.01) in a dose-dependent manner. Anti-hypoxic potency of PESI and octacosane obtained by chemical induced hypoxic model indicated that they significantly increase survival time(P<0.05)of hypoxia mice than acetazolamide. Conclusion PESI and octacosane have good anti-hypoxia activity.
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