Study of total celosins on liver protection in different liver damage model

TANG Ying; LIANG Lin; GUO Meili

doi:10.3969/j.issn.1006-0111.2016.03.003

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Objective To study the liver protection of total celosins (CES) in different liver damage models. Method Acute liver damage mouse model, chronic liver damage rat model and immune liver damage mouse model were established for this study. Liver function tests, liver lipid peroxidation indicators and liver pathology were observed. Results CES of each dose group can lower serum ALT and AST in different degrees, can significantly reduce the content of MDA in liver homogenate, while can increase SOD activity. Pathological examination showed that animals administered significantly reduced the degree of liver cell damage. Conclusion CES have protective effects on acute liver damage induced by CCl₄, chronic liver damage induced by CCl₄ and immunological liver damage induced by concanavalin A. Its hepatoprotective effect may be related to its antioxidant effects.

Study of total celosins on liver protection in different liver damage model

1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China

2. Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

3. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China;Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2016-03-01

Rev Recd Date: 2016-04-26

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Abstract: Objective To study the liver protection of total celosins (CES) in different liver damage models. Method Acute liver damage mouse model, chronic liver damage rat model and immune liver damage mouse model were established for this study. Liver function tests, liver lipid peroxidation indicators and liver pathology were observed. Results CES of each dose group can lower serum ALT and AST in different degrees, can significantly reduce the content of MDA in liver homogenate, while can increase SOD activity. Pathological examination showed that animals administered significantly reduced the degree of liver cell damage. Conclusion CES have protective effects on acute liver damage induced by CCl₄, chronic liver damage induced by CCl₄ and immunological liver damage induced by concanavalin A. Its hepatoprotective effect may be related to its antioxidant effects.

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Study of total celosins on liver protection in different liver damage model

doi: 10.3969/j.issn.1006-0111.2016.03.003

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