Role of cyclooxygenases in radiation enteropathy

TAO Yulong; YANG Hong; TAO Xia

doi:10.3969/j.issn.1006-0111.2016.03.001

Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review, editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name

E-mail

Phone

Title

Content

Verification Code

Gastrointestinal tract is one of the most sensitive organs exposed to ionizing radiation. Radiation enteropathy is a hot topic in radiobiological field. Cumulative evidences demonstrated that cyclooxygenases (COXs) might contribute substantially to attenuating intestinal damage provoked by irradiation. The role of cyclooxygenases in radiation-induced intestinal damage was reviewed in this paper.

Role of cyclooxygenases in radiation enteropathy

Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China

Received Date: 2015-09-06

Rev Recd Date: 2015-10-21

Key words:

Abstract: Gastrointestinal tract is one of the most sensitive organs exposed to ionizing radiation. Radiation enteropathy is a hot topic in radiobiological field. Cumulative evidences demonstrated that cyclooxygenases (COXs) might contribute substantially to attenuating intestinal damage provoked by irradiation. The role of cyclooxygenases in radiation-induced intestinal damage was reviewed in this paper.

HTML

Reference (19)

[1]	Williams JP, Brown SL, Georges GE, et al. Animal models for medical countermeasures to radiation exposure[J]. Radiat Res, 2010,173(4):557-578.
[2]	Hauer-Jensen M, Denham JW, Andreyev HJ. Radiation enteropathy- -pathogenesis, treatment and prevention[J]. Nat Rev Gastroenterol Hepatol, 2014,11(8):470-479.
[3]	Theis VS, Sripadam R, Ramani V, et al. Chronic radiation enteritis[J]. Clin Oncol (R Coll Radiol), 2010,22(1):70-83.
[4]	Singh VK, Newman VL, Berg AN, et al. Animal models for acute radiation syndrome drug discovery[J]. Expert Opin Drug Discov, 2015,10(5):497-517.
[5]	Houchen CW, Stenson WF, Cohn SM. Disruption of cyclooxygenase-1 gene results in an impaired response to radiation injury[J]. Am J Physiol Gastrointest Liver Physiol, 2000,279(5):G858-865.
[6]	Ciorba MA, Riehl TE, Rao MS, et al. Lactobacillus probiotic protects intestinal epithelium from radiation injury in a TLR-2/cyclo-oxygenase-2-dependent manner[J]. Gut, 2012,61(6):829-838.
[7]	Vance DE, Vance JE. Biochemistry of lipids, lipoproteins and membranes[M]. 5th ed. San Diego:Elsevier, 2008:332-361.
[8]	Smith WL, Song I. The enzymology of prostaglandin endoperoxide H synthases-1 and -2[J]. Prostaglandins Other Lipid Mediat, 2002,(68-69):115-128.
[9]	Jackson LM, Wu KC, Mahida YR, et al. Cyclooxygenase (COX) 1 and 2 in normal, inflamed, and ulcerated human gastric mucosa[J]. Gut, 2000,47(6):762-770.
[10]	Zhang Z, Andoh A, Inatomi O, et al. Interleukin-17 and lipopolysaccharides synergistically induce cyclooxygenase-2 expression in human intestinal myofibroblasts[J]. J Gastroenterol Hepatol, 2005,20(4):619-627.
[11]	Brown SL, Riehl TE, Walker MR, et al. Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury[J]. J Clin Invest, 2007,117(1):258-269.
[12]	Hall E J. Radiobiology for the radiologist[M]. 5th ed. USA:Lippincott Williams & Wilkins, 2000:32-66.
[13]	Shadad AK, Sullivan FJ, Martin JD, et al. Gastrointestinal radiation injury:symptoms, risk factors and mechanisms[J]. World J Gastroenterol, 2013,19(2):185-198.
[14]	Barker N. Adult intestinal stem cells:critical drivers of epithelial homeostasis and regeneration[J]. Nat Rev Mol Cell Biol, 2014,15(1):19-33.
[15]	Riehl T, Cohn S, Tessner T, et al. Lipopolysaccharide is radioprotective in the mouse intestine through a prostaglandin-mediated mechanism[J]. Gastroenterology, 2000,118(6):1106-1016.
[16]	Walker MR, Brown SL, Riehl TE, et al. Growth factor regulation of prostaglandin-endoperoxide synthase 2(Ptgs2) expression in colonic mesenchymal stem cells[J]. J Biol Chem, 2010,285(7):5026-5039.
[17]	Zhang X, Schwarz EM, Young DA, et al. Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair[J]. J Clin Invest, 2002,109(11):1405-1415.
[18]	Kurtova AV, Xiao J, Mo Q, et al. Blocking PGE₂-induced tumour repopulation abrogates bladder cancer chemoresistance[J]. Nature, 2015,517(7533):209-213.
[19]	Houchen CW, Sturmoski MA, Anant S, et al. Prosurvival and antiapoptotic effects of PGE₂ in radiation injury are mediated by EP₂ receptor in intestine[J]. Am J Physiol Gastrointest Liver Physiol, 2003,284(3):G490-498.

Message Board

Role of cyclooxygenases in radiation enteropathy

doi: 10.3969/j.issn.1006-0111.2016.03.001

Abstract

References

Proportional views

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Related

Proportional views