2000 Vol. 18, No. 1
Display Method:
The pharmacokinetics in rabbits of the fluorofur implants made by irradiation-induced polymerization
2000, (1): 19-21.
Abstract:
OBJECTIVE To investigate the in vitro release and the pharmacokinetics in rabbits of the fluorofur implants.METHODS The implant,poly(2-hydroxyelthyl methacrylate)[poly(HEMA)]-collagen composite,made by fluorofur injection. RESULTS The release profiles in vitro conformed to Higuchi kinetics. The release index of the implant was t1/2=9.9h, t0.9=32.7h. The pharmacokinetic parameters in rabbits were:AUC=268.666h·μg/ml,MRT=41.704h,ka=0.334/h. CONCLUSION: The results clearly indicated that the poly(HEMA)-collagen hydrogel made by irradiation-induced polymerization offers excellent potential as a carrier for the sustained release implant of anticancer drugs.
OBJECTIVE To investigate the in vitro release and the pharmacokinetics in rabbits of the fluorofur implants.METHODS The implant,poly(2-hydroxyelthyl methacrylate)[poly(HEMA)]-collagen composite,made by fluorofur injection. RESULTS The release profiles in vitro conformed to Higuchi kinetics. The release index of the implant was t1/2=9.9h, t0.9=32.7h. The pharmacokinetic parameters in rabbits were:AUC=268.666h·μg/ml,MRT=41.704h,ka=0.334/h. CONCLUSION: The results clearly indicated that the poly(HEMA)-collagen hydrogel made by irradiation-induced polymerization offers excellent potential as a carrier for the sustained release implant of anticancer drugs.
2000, (1): 21-24.
Abstract:
OBJECTIVE To study the preparation technique and qualitative identification of ShuLe granules(preparation of chinese medicine).METHODS The optimal extractive factors were found with orthogonal experiment design with table L9(34), the index were the extraction recovery rate. Thin-layer chromatography was employed for qualitative identification of the herbs of Ligusticum Chuanxiog Hort, Angelica Sinensis (Oliv) and Corydalis Turtschaninovii Bess. RESULTS The optimal extract technique was boiling two times, the first boiling 1.5h, adding 15 times content water, the second boiling 1.0h, adding 10 times content water, and definition of the sports was good. CONCLUSION: The extraction technique and the quality standards are feasible.
OBJECTIVE To study the preparation technique and qualitative identification of ShuLe granules(preparation of chinese medicine).METHODS The optimal extractive factors were found with orthogonal experiment design with table L9(34), the index were the extraction recovery rate. Thin-layer chromatography was employed for qualitative identification of the herbs of Ligusticum Chuanxiog Hort, Angelica Sinensis (Oliv) and Corydalis Turtschaninovii Bess. RESULTS The optimal extract technique was boiling two times, the first boiling 1.5h, adding 15 times content water, the second boiling 1.0h, adding 10 times content water, and definition of the sports was good. CONCLUSION: The extraction technique and the quality standards are feasible.
2000, (1): 24-26.
Abstract:
OBJECTIVE To determine the release rate of compound sulfanethoxazole tablet.METHODS Refering to USP(ⅩⅫ), the release rate of the sample from five domestic plants was determined by dualwavelength spectrophotometry. RESULTS The release rates of the sample from five domestic plants were markedly different(P<0.01). CONCLUTION It's necessary to determine the release rate for ensuring the quality of compound sulfamethoxazole tablet made in our country.
OBJECTIVE To determine the release rate of compound sulfanethoxazole tablet.METHODS Refering to USP(ⅩⅫ), the release rate of the sample from five domestic plants was determined by dualwavelength spectrophotometry. RESULTS The release rates of the sample from five domestic plants were markedly different(P<0.01). CONCLUTION It's necessary to determine the release rate for ensuring the quality of compound sulfamethoxazole tablet made in our country.
2000, (1): 32-34.
Abstract:
OBJECTIVE To establish a method for the determination of lomefloxacin aspartate injection.METHODS The concentration of lomenfloxacin aspartate was assayed on a μ-Bondapak-C 18 column with a mobile ph
OBJECTIVE To establish a method for the determination of lomefloxacin aspartate injection.METHODS The concentration of lomenfloxacin aspartate was assayed on a μ-Bondapak-C 18 column with a mobile ph
2000, (1): 39-42.
Abstract:
Apoptosis is one form of cell death which commonly occurs during many physiological and pathological processes.The principle,working procedures and related problems of ELISA assay were described in detail in this article, which allows quantitative determination of mono and ligonucleosomes in apoptotic cells.
Apoptosis is one form of cell death which commonly occurs during many physiological and pathological processes.The principle,working procedures and related problems of ELISA assay were described in detail in this article, which allows quantitative determination of mono and ligonucleosomes in apoptotic cells.
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