摄食的神经及内分泌调节

孙旸; 王鹏源; 刘霞

doi:10.3969/j.issn.1006-0111.2016.06.006

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

x 关闭永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

摄食的神经及内分泌调节

孙旸, 王鹏源, 刘霞

文章导航 > 药学实践与服务 > 2016 > 34(6): 501-506,521

孙旸, 王鹏源, 刘霞. 摄食的神经及内分泌调节[J]. 药学实践与服务, 2016, 34(6): 501-506,521. doi: 10.3969/j.issn.1006-0111.2016.06.006

引用本文:

孙旸, 王鹏源, 刘霞. 摄食的神经及内分泌调节[J]. 药学实践与服务, 2016, 34(6): 501-506,521. doi: 10.3969/j.issn.1006-0111.2016.06.006

SUN Yang, WANG Pengyuan, LIU Xia. Neuronal and endocrine regulation of food intake[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 501-506,521. doi: 10.3969/j.issn.1006-0111.2016.06.006

Citation:

SUN Yang, WANG Pengyuan, LIU Xia. Neuronal and endocrine regulation of food intake[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(6): 501-506,521. doi: 10.3969/j.issn.1006-0111.2016.06.006

摄食的神经及内分泌调节

doi: 10.3969/j.issn.1006-0111.2016.06.006

第二军医大学药学院药理学教研室, 上海 200433

基金项目: “重大新药创制”科技重大专项（2014ZX09J14103-08C），国家自然科学基金（81473259）

Neuronal and endocrine regulation of food intake

Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

摘要: 摄食的神经调控和激素调节拓展了我们对于能量稳态的认识。中枢神经系统接受中枢和外周的多种内分泌信号，调节摄食和能量消耗，以维持能量代谢平衡。神经系统和内分泌系统相互作用，共同调控机体的摄食行为。本文综述了神经及内分泌系统对于摄食行为的调控机制，望有助于肥胖、代谢性疾病以及其他营养性疾病的研究和治疗。
- 摄食 /
- 弓状核 /
- 孤束核 /
- 内分泌 /
- 能量稳态
Abstract: The neuronal and hormonal regulations of food intake expand our knowledge about energy balance. The central nervous system integrates endocrine signals to regulate food intake and energy consumption. The nervous system and endocrine system interact with each other to regulate feeding behavior. This paper was a review of the neuronal and endocrine regulation of food intake, and offered a revealing insight for the study and treatment of metabolic disorders.
- food intake /
- arcuate nucleus /
- nucleus tractus solitarii /
- endocrine /
- energy homeostasis

[1]	Boguszewski CL, Paz-Filho G, Velloso LA. Neuroendocrine body weight regulation:integration between fat tissue, gastrointestinal tract, and the brain[J]. Endokrynol Pol, 2010, 61(2):194-206.
[2]	Morton GJ, Cummings DE, Baskin DG, et al. Central nervous system control of food intake and body weight[J]. Nature, 2006, 443(7109):289-295.
[3]	Kennedy GC. The role of depot fat in the hypothalamic control of food intake in the rat[J]. Proc R Soc Lond B Biol Sci, 1953, 140(901):578-596.
[4]	Schwartz MW, Woods SC, Porte D, Jr., et al. Central nervous system control of food intake[J]. Nature, 2000, 404(6778):661-671.
[5]	Gibbs J, Young RC, Smith GP. Cholecystokinin decreases food intake in rats[J]. J Comp Physiol Psychol, 1973, 84(3):488-495.
[6]	Cowley MA,Smart JL,Rubinstein M,et al.Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus[J].Nature,2001,411(6836):480-484.
[7]	Horvath TL. The hardship of obesity:a soft-wired hypothalamus[J]. Nat Neurosci, 2005, 8(5):561-565.
[8]	Myers MG, Jr., Munzberg H, Leinninger GM, et al. The geometry of leptin action in the brain:more complicated than a simple ARC[J]. Cell Metab, 2009, 9(2):117-123.
[9]	Grill HJ. Distributed neural control of energy balance:contributions from hindbrain and hypothalamus[J]. Obesity (Silver Spring), 2006, 14 Suppl 5:216S-221S.
[10]	Grill HJ. Leptin and the systems neuroscience of meal size control[J]. Front Neuroendocrinol, 2010, 31(1):61-78.
[11]	Ravinet Trillou C, Delgorge C, Menet C, et al. CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity[J]. Int J Obes Relat Metab Disord, 2004, 28(4):640-648.
[12]	Farooqi S, O'Rahilly S. Genetics of obesity in humans[J]. Endocr Rev, 2006, 27(7):710-718.
[13]	Niswender KD, Morrison CD, Clegg DJ, et al. Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus:a key mediator of insulin-induced anorexia[J]. Diabetes, 2003, 52(2):227-231.
[14]	Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signalling pathways:insights into insulin action[J]. Nat Rev Mol Cell Biol, 2006, 7(2):85-96.
[15]	Ahima RS, Lazar MA. Adipokines and the peripheral and neural control of energy balance[J]. Mol Endocrinol, 2008, 22(5):1023-1031.
[16]	Moller DE. Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes[J]. Trends Endocrinol Metab, 2000, 11(6):212-217.
[17]	Wallenius K, Jansson JO, Wallenius V. The therapeutic potential of interleukin-6 in treating obesity[J]. Expert Opin Biol Ther, 2003, 3(7):1061-1070.
[18]	Cummings DE, Overduin J. Gastrointestinal regulation of food intake[J]. J Clin Invest, 2007, 117(1):13-23.
[19]	Drucker DJ. The biology of incretin hormones[J]. Cell Metab, 2006, 3(3):153-165.
[20]	Wynne K, Park AJ, Small CJ, et al. Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects:a double-blind, randomized, controlled trial[J]. Diabetes, 2005, 54(8):2390-2395.
[21]	Degen L, Oesch S, Casanova M, et al. Effect of peptide YY3-36 on food intake in humans[J]. Gastroenterology, 2005, 129(5):1430-1436.
[22]	Kovacs EM, Lejeune MP, Westerterp-Plantenga MS. The effects of enterostatin intake on food intake and energy expenditure[J]. Br J Nutr, 2003, 90(1):207-214.
[23]	Fujimoto K, Fukagawa K, Sakata T, et al. Suppression of food intake by apolipoprotein A-IV is mediated through the central nervous system in rats[J]. J Clin Invest, 1993, 91(4):1830-1833.
[24]	Hollander P, Maggs DG, Ruggles JA, et al. Effect of pramlintide on weight in overweight and obese insulin-treated type 2 diabetes patients[J]. Obes Res, 2004, 12(4):661-668.
[25]	Obici S, Feng Z, Morgan K, et al. Central administration of oleic acid inhibits glucose production and food intake[J]. Diabetes, 2002, 51(2):271-275.

点击查看大图

计量

文章访问数: 3515
HTML全文浏览量: 449
PDF下载量: 804
被引次数: 0

摄食的神经及内分泌调节

doi: 10.3969/j.issn.1006-0111.2016.06.006

第二军医大学药学院药理学教研室, 上海 200433

基金项目: “重大新药创制”科技重大专项（2014ZX09J14103-08C），国家自然科学基金（81473259）

收稿日期: 2016-06-02
修回日期: 2016-07-19

关键词:

摄食 /

弓状核 /

孤束核 /

内分泌 /

能量稳态

摘要: 摄食的神经调控和激素调节拓展了我们对于能量稳态的认识。中枢神经系统接受中枢和外周的多种内分泌信号，调节摄食和能量消耗，以维持能量代谢平衡。神经系统和内分泌系统相互作用，共同调控机体的摄食行为。本文综述了神经及内分泌系统对于摄食行为的调控机制，望有助于肥胖、代谢性疾病以及其他营养性疾病的研究和治疗。