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Volume 29 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2011  >  29(6): 457-459

Tang Zhong-jin, Wang Xiu-ying, Chen Hong, Guan Ying, Zhu Quan-ying, Su Ding-feng. Effect of tetrandrine on 45Ca influx in rat aorta in vitro[J]. Journal of Pharmaceutical Practice and Service, 1995, (2): 72-75.
Citation: CHEN Rui, CHU Zhong-ying, ZHANG Ji-chun, TIAN Lan. Determination of forbidden addition drugs of Diazepam,Clonazepam and Estazolam in tranquilizing mind traditional Chinese medicine by UPLC-MS/MS[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(6): 457-459.
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Determination of forbidden addition drugs of Diazepam,Clonazepam and Estazolam in tranquilizing mind traditional Chinese medicine by UPLC-MS/MS

  • Shanghai Songjiang Institute for Food and Drug Control, Shanghai 201600, China

  • Received Date: 2011-05-29
  • Rev Recd Date: 2011-06-15
  • Objective To establish a specific method for determination of forbidden addition drugs of Diazepam,Clonazepan and Estazolam in tranquilizing mind Traditional Chinese Medicine. Methods Diazepam, Clonazepam and Estazolam were determined and analyzed by UPLC-MS/MS. ACQUITY BEH C18 analysis column(2.1 mm×50 mm,1.7 μm) was used with the mobile phase of 10 mmol/L ammonium acetate and acetonitrile(90：10) with gradient elution. The flow rate was 0.4 ml/min,and the detection wavelength was 254 nm.EIS ion source was used with positive ion monitoring. Results The standard curves of Diazepam,Clonazepam and Estazolam showed good linearity over the concentration rang of 109.8~878.4, 102.1~816.8,106.9~855.2 ng/ml,The detection limits were 0.06,2.5×10-3,2.8×10-3 ng,the quantitation limits were 0.19,8.2×10-3,9.2×10-3 ng,the average recoveries of three chemicals was 95.7%~103.7%. Conclution The method was specific,sensitive,easily and quickly,which could be used to detect Diazepam,Clonazepan and Estazolam in tranquilizing mind traditional Chinese medicine.
  • [1] 李欣荣,陈安珍,杨 钊.UPLC-MS/MS检测消肿止痛类中成药中违禁添加的双氯芬酸钠和氨基比林[J].药物分析杂志,2010,30(7): 1294.
    [2] 国家食品药品监督管理局药品检验补充检验方法和检验项目批准件汇编[S].批准件编号2006008:109; 2006024:139.
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Determination of forbidden addition drugs of Diazepam,Clonazepam and Estazolam in tranquilizing mind traditional Chinese medicine by UPLC-MS/MS

  • Shanghai Songjiang Institute for Food and Drug Control, Shanghai 201600, China
  • Received Date: 2011-05-29
  • Rev Recd Date: 2011-06-15

Abstract: Objective To establish a specific method for determination of forbidden addition drugs of Diazepam,Clonazepan and Estazolam in tranquilizing mind Traditional Chinese Medicine. Methods Diazepam, Clonazepam and Estazolam were determined and analyzed by UPLC-MS/MS. ACQUITY BEH C18 analysis column(2.1 mm×50 mm,1.7 μm) was used with the mobile phase of 10 mmol/L ammonium acetate and acetonitrile(90：10) with gradient elution. The flow rate was 0.4 ml/min,and the detection wavelength was 254 nm.EIS ion source was used with positive ion monitoring. Results The standard curves of Diazepam,Clonazepam and Estazolam showed good linearity over the concentration rang of 109.8~878.4, 102.1~816.8,106.9~855.2 ng/ml,The detection limits were 0.06,2.5×10-3,2.8×10-3 ng,the quantitation limits were 0.19,8.2×10-3,9.2×10-3 ng,the average recoveries of three chemicals was 95.7%~103.7%. Conclution The method was specific,sensitive,easily and quickly,which could be used to detect Diazepam,Clonazepan and Estazolam in tranquilizing mind traditional Chinese medicine.

Tang Zhong-jin, Wang Xiu-ying, Chen Hong, Guan Ying, Zhu Quan-ying, Su Ding-feng. Effect of tetrandrine on 45Ca influx in rat aorta in vitro[J]. Journal of Pharmaceutical Practice and Service, 1995, (2): 72-75.
Citation: CHEN Rui, CHU Zhong-ying, ZHANG Ji-chun, TIAN Lan. Determination of forbidden addition drugs of Diazepam,Clonazepam and Estazolam in tranquilizing mind traditional Chinese medicine by UPLC-MS/MS[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(6): 457-459.
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