YUAN Wen-lin, XIA Tian-yi, SHEN Song-zhang, WANG Xiao-yan, HE Bang-ping, SUN Qing-yan. Synthesis of monastrol catalyzed by 1-butyl-3-methylimidazolium (L)-camphorsulfonate[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(6): 455-456,459.
| Citation:
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YUAN Wen-lin, XIA Tian-yi, SHEN Song-zhang, WANG Xiao-yan, HE Bang-ping, SUN Qing-yan. Synthesis of monastrol catalyzed by 1-butyl-3-methylimidazolium (L)-camphorsulfonate[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(6): 455-456,459.
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Synthesis of monastrol catalyzed by 1-butyl-3-methylimidazolium (L)-camphorsulfonate
- 1.
Pharmacy Team, Graduate Management Unit, Second Military Medical University, Shanghai 200433, China
- 2.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China
- Received Date: 2010-12-22
- Rev Recd Date:
2011-05-23
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Abstract
Objective To explore a convenient and environmentally friendly benign synthesis method of monastrol. Methods Monastrol was synthesized from m-hydroxybenzaldehyde, ethyl acetoacetate and thiourea through the Biginelli reaction catalyzed by 1-butyl-3-methylimidazolium (L)-camphorsulfonate under microwave irradiation without a solvent. Results The green room temperature ionic liquid could catalyze the Biginelli reaction to get monsatrol under microwave irradiation without a solvent. The process was easy to operate and was environmentally friendly. Conclusion Microwave accelerated solvent-free Biginelli reaction using 1-butyl-3-methylimidazolium (L)-camphorsulfonate as catalyst, which was a convenient and environmentally benign synthesis method of monastrol.
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