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Volume 28 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(5): 363-365,368

LIU Fu-qiang, WANG Yan-ping, ZHAO Nan, WANG Xiang-yang, CUI Hai-zhen. The pharmacokinetics study of tinidazole pectin matrics colon-specific sustained-release tablets in dogs[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 363-365,368.
Citation: LIU Fu-qiang, WANG Yan-ping, ZHAO Nan, WANG Xiang-yang, CUI Hai-zhen. The pharmacokinetics study of tinidazole pectin matrics colon-specific sustained-release tablets in dogs[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 363-365,368.
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The pharmacokinetics study of tinidazole pectin matrics colon-specific sustained-release tablets in dogs

  • 1.

    208th Hospital of PLA,Changchun 130062,China

  • 2.

    Institute of Pharmaceutical Research,Tasly Group,Tianjin 300142,China

  • 3.

    School of pharmacy,Yanbian University,Yanji 133000,China

  • Received Date: 2010-04-26
  • Rev Recd Date: 2010-06-18
  • Objective To develop a method to study the pharmacokinetics of tinidazole pectin matrics colon-specific sustained-release tablets in dogs. Methods The plasma concentrations were determined by HPLC.Two-period cross over self-control trail was conducted to 6 Beagle dogs which were administrated a single dose of the oral test tablets and reference tablets. Results The pharmacokinetics of two preparations fitted to two-compartment model.The main pharmacokinetic parameters:Tmax were(7.0±0.92)and(2.0±0.31) h;Cmax were(66.97±5.9)and(112.2±7.4) μg/L;AUC0-t were(1 243.88±25.67)and(1 523.84±27.89) mg·h/L;AUC0-∞ were(1 277.18±30.58)and(1 548.67±20.89) mg·h/L and test tablets showed a relative bioavailability of 82.47%. Conclusion The method was accurate and sensitive which was suitable for Tinidazole pectin matrics pharmacokinetics study.
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The pharmacokinetics study of tinidazole pectin matrics colon-specific sustained-release tablets in dogs

  • 1. 208th Hospital of PLA,Changchun 130062,China
  • 2. Institute of Pharmaceutical Research,Tasly Group,Tianjin 300142,China
  • 3. School of pharmacy,Yanbian University,Yanji 133000,China
  • Received Date: 2010-04-26
  • Rev Recd Date: 2010-06-18

Abstract: Objective To develop a method to study the pharmacokinetics of tinidazole pectin matrics colon-specific sustained-release tablets in dogs. Methods The plasma concentrations were determined by HPLC.Two-period cross over self-control trail was conducted to 6 Beagle dogs which were administrated a single dose of the oral test tablets and reference tablets. Results The pharmacokinetics of two preparations fitted to two-compartment model.The main pharmacokinetic parameters:Tmax were(7.0±0.92)and(2.0±0.31) h;Cmax were(66.97±5.9)and(112.2±7.4) μg/L;AUC0-t were(1 243.88±25.67)and(1 523.84±27.89) mg·h/L;AUC0-∞ were(1 277.18±30.58)and(1 548.67±20.89) mg·h/L and test tablets showed a relative bioavailability of 82.47%. Conclusion The method was accurate and sensitive which was suitable for Tinidazole pectin matrics pharmacokinetics study.

LIU Fu-qiang, WANG Yan-ping, ZHAO Nan, WANG Xiang-yang, CUI Hai-zhen. The pharmacokinetics study of tinidazole pectin matrics colon-specific sustained-release tablets in dogs[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 363-365,368.
Citation: LIU Fu-qiang, WANG Yan-ping, ZHAO Nan, WANG Xiang-yang, CUI Hai-zhen. The pharmacokinetics study of tinidazole pectin matrics colon-specific sustained-release tablets in dogs[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 363-365,368.
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