Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 28 Issue 5
. 
Turn off MathJax
Article Contents
Abstract
References
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(5): 339-341,344

YANG Ling, ZHONG Yan-qiang. Development of nimodipine solid dispersion[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 339-341,344.
Citation: YANG Ling, ZHONG Yan-qiang. Development of nimodipine solid dispersion[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 339-341,344.
shu

Development of nimodipine solid dispersion

  • School of pharmacy,Second Military Medical University,Shanghai 200433,China

  • Received Date: 2012-02-03
  • Rev Recd Date: 2010-04-06
  • Objective To prepare Nimodipine solid dispersion and increase its dissolution rate.Methonds Using polyvinylpyrrolidone(PVP) as a carrier,nimodipine solid dispersion was prepared by spray-drying method.differential scanning calorimetry and X-Ray powder Diffractometer were used to investigate the status of nimodipine in carriers,and dissolution characteristics were studied in vitro. Results Nimodipine was in the form of molecular in its carrier.The solubility of solid dispersion was significantly increased comparing with that of the pure drug or physical mixtures.Dissolution Results showed that higher carrier-Nimodipine ratio led to faster drug dissolution,t50 of solid dispersions(NimodipinePVP=1:3) is only 0.972 6 min. Conclusion Polyvinylpyrrolidone(PVP) as a carrier of Nimodipine solid dispersion has a high load ability;spray-drying method has good reproducibility;dispersoid particles need not to be smashed and can satisfy request for each kind of solid dosage form.Spray drying technique is a ideal method for the preparation of nimodipine solid dispersion.
  • Created with Highcharts 5.0.7Amount of accessChart context menuAbstract Views, HTML Views, PDF Downloads StatisticsAbstract ViewsHTML ViewsPDF Downloads2024-052024-062024-072024-082024-092024-102024-112024-122025-012025-022025-032025-0400.511.522.5Highcharts.com
    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 92.1 %FULLTEXT: 92.1 %META: 6.3 %META: 6.3 %PDF: 1.6 %PDF: 1.6 %FULLTEXTMETAPDFHighcharts.com
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 18.6 %其他: 18.6 %China: 0.4 %China: 0.4 %上海: 2.8 %上海: 2.8 %北京: 24.5 %北京: 24.5 %台州: 0.4 %台州: 0.4 %广西河池金城江区: 0.4 %广西河池金城江区: 0.4 %张家口: 0.4 %张家口: 0.4 %昆明: 0.4 %昆明: 0.4 %杭州: 1.2 %杭州: 1.2 %梧州: 0.4 %梧州: 0.4 %漳州: 0.8 %漳州: 0.8 %烟台: 0.4 %烟台: 0.4 %石家庄: 0.4 %石家庄: 0.4 %芒廷维尤: 12.3 %芒廷维尤: 12.3 %西宁: 35.6 %西宁: 35.6 %郑州: 0.8 %郑州: 0.8 %重庆: 0.4 %重庆: 0.4 %其他China上海北京台州广西河池金城江区张家口昆明杭州梧州漳州烟台石家庄芒廷维尤西宁郑州重庆Highcharts.com
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2878) PDF downloads(1070) Cited by()

Related
Proportional views

Development of nimodipine solid dispersion

  • School of pharmacy,Second Military Medical University,Shanghai 200433,China
  • Received Date: 2012-02-03
  • Rev Recd Date: 2010-04-06

Abstract: Objective To prepare Nimodipine solid dispersion and increase its dissolution rate.Methonds Using polyvinylpyrrolidone(PVP) as a carrier,nimodipine solid dispersion was prepared by spray-drying method.differential scanning calorimetry and X-Ray powder Diffractometer were used to investigate the status of nimodipine in carriers,and dissolution characteristics were studied in vitro. Results Nimodipine was in the form of molecular in its carrier.The solubility of solid dispersion was significantly increased comparing with that of the pure drug or physical mixtures.Dissolution Results showed that higher carrier-Nimodipine ratio led to faster drug dissolution,t50 of solid dispersions(NimodipinePVP=1:3) is only 0.972 6 min. Conclusion Polyvinylpyrrolidone(PVP) as a carrier of Nimodipine solid dispersion has a high load ability;spray-drying method has good reproducibility;dispersoid particles need not to be smashed and can satisfy request for each kind of solid dosage form.Spray drying technique is a ideal method for the preparation of nimodipine solid dispersion.

YANG Ling, ZHONG Yan-qiang. Development of nimodipine solid dispersion[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 339-341,344.
Citation: YANG Ling, ZHONG Yan-qiang. Development of nimodipine solid dispersion[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(5): 339-341,344.
shu

    HTML

Catalog

  • HTML

版权所有：《药学实践与服务》编辑委员会

Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

网站备案号 沪ICP备05003363号-1

Supported by: Beijing Renhe Information Technology Co., Ltd.  

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return