Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 28 Issue 4
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(4): 299-303

QIU Xiao-min, LIU Jia, FENG Ji-lu, NIU Chun-juan, LI Ke. Studies on synthesis and antiviral activities of a novel acyclic nucleoside phosphonates analogues on HBV[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 299-303.
Citation: QIU Xiao-min, LIU Jia, FENG Ji-lu, NIU Chun-juan, LI Ke. Studies on synthesis and antiviral activities of a novel acyclic nucleoside phosphonates analogues on HBV[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 299-303.
shu

Studies on synthesis and antiviral activities of a novel acyclic nucleoside phosphonates analogues on HBV

  • Department of Medical Chemistry,School of Pharmacy,Second Military Medical University,Shanghai 200433,China

  • Received Date: 2009-12-14
  • Rev Recd Date: 2010-01-26
  • Objective To study of design and synthesis of the novel acyclic nucleoside phosphonates analogues and study their activities of inhibiting HBV. Methods Based on the chemical structure of PMEA,and according to the theory of bioisostere,a 8-aza-6-thiophenyl group was introduced and a series of title compounds were synthesized.All of them were confirmed by IR,1H-NMR and MS.Preliminary pharmacological test of compounds 1a-1e was made on HBV. Results Ten compounds were synthesized.The test Results show the inhibitory rate of 1a-1e compounds on HBsAg and HBeAg is higher than PMEA.The inhibitory rate of compound 1e on HBV-DNA is correspond with PMEA. Conclusion The PMEA derivatives with a 8-aza-6-thiophenyl group have high activity on inhibiting HBsAg,HBeAg and HBV-DNA.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2163) PDF downloads(411) Cited by()

Related
Proportional views

Studies on synthesis and antiviral activities of a novel acyclic nucleoside phosphonates analogues on HBV

  • Department of Medical Chemistry,School of Pharmacy,Second Military Medical University,Shanghai 200433,China
  • Received Date: 2009-12-14
  • Rev Recd Date: 2010-01-26

Abstract: Objective To study of design and synthesis of the novel acyclic nucleoside phosphonates analogues and study their activities of inhibiting HBV. Methods Based on the chemical structure of PMEA,and according to the theory of bioisostere,a 8-aza-6-thiophenyl group was introduced and a series of title compounds were synthesized.All of them were confirmed by IR,1H-NMR and MS.Preliminary pharmacological test of compounds 1a-1e was made on HBV. Results Ten compounds were synthesized.The test Results show the inhibitory rate of 1a-1e compounds on HBsAg and HBeAg is higher than PMEA.The inhibitory rate of compound 1e on HBV-DNA is correspond with PMEA. Conclusion The PMEA derivatives with a 8-aza-6-thiophenyl group have high activity on inhibiting HBsAg,HBeAg and HBV-DNA.

QIU Xiao-min, LIU Jia, FENG Ji-lu, NIU Chun-juan, LI Ke. Studies on synthesis and antiviral activities of a novel acyclic nucleoside phosphonates analogues on HBV[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 299-303.
Citation: QIU Xiao-min, LIU Jia, FENG Ji-lu, NIU Chun-juan, LI Ke. Studies on synthesis and antiviral activities of a novel acyclic nucleoside phosphonates analogues on HBV[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 299-303.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return