Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review, editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!
LU Ming-zhu, ZHANG Zhi-qiang, YI Jia, CHEN Wan-sheng, HOU Zhong-hai, LI Tie-jun. Study on the effect and mechanisms of timosaponin B-Ⅱ on antidepressant[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 283-287.
Citation:
LU Ming-zhu, ZHANG Zhi-qiang, YI Jia, CHEN Wan-sheng, HOU Zhong-hai, LI Tie-jun. Study on the effect and mechanisms of timosaponin B-Ⅱ on antidepressant[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 283-287.
Study on the effect and mechanisms of timosaponin B-Ⅱ on antidepressant
Department of Pharmacy,Changzheng Hospital,Second Military Medical University,Shanghai 200031,China;
2.
Department of Pharmacy,No.321 Hospital of PLA,Baicheng 137000,China
3.
Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China
Received Date: 2010-03-25
Rev Recd Date:
2010-06-02
Abstract
Objective To study the effect and mechanisms of timosaponin B-Ⅱ on depression. Methods The tail suspension test(TST),forced swimming test(FST),open field activity test(OFA),APO-induced synergistic action test,inhibiting reuptake of monoamine neurotransmitters and monoamine oxidase inhibitor(MAOI) test,yohimbine-induced lethality test and 5-HTP-induced head-twitch test were carried out to examine the antidepressant effect and mechanisms of timosaponin B-Ⅱ in rats.Immobility duration in FST and TST,spontaneous activity frequency in OFA,the stereotyped behaviors scores in APO-induced synergistic action test,and mortality in the other tests were observed. Results Timosaponin B-Ⅱ(100、150mg/kg) could effectively shorten the immobility time in TST and FST,but all dosages showed no significant effect on the spontaneous activity frequency in OFA.Timosaponin B-Ⅱ(150 mg/kg) significantly increased the rate of death of injecting dopamine,but had no obvious effect on the inhibiting reuptake of NE.Timosaponin B-Ⅱ(100、150 mg/kg) enhanced the apomorphine-induced stereotypy remarkably,which with statistically significant differences(P<0.05),and increased the head-twitch response evoked by 5-HTP,but had no effect on the yohimbine toxicity. Conclusion Timosaponin B-Ⅱhas significant antidepressant effect which may be related to the potentiation of brain 5-HT nerve system and DA nerve system.
Abstract: Objective To study the effect and mechanisms of timosaponin B-Ⅱ on depression. Methods The tail suspension test(TST),forced swimming test(FST),open field activity test(OFA),APO-induced synergistic action test,inhibiting reuptake of monoamine neurotransmitters and monoamine oxidase inhibitor(MAOI) test,yohimbine-induced lethality test and 5-HTP-induced head-twitch test were carried out to examine the antidepressant effect and mechanisms of timosaponin B-Ⅱ in rats.Immobility duration in FST and TST,spontaneous activity frequency in OFA,the stereotyped behaviors scores in APO-induced synergistic action test,and mortality in the other tests were observed. Results Timosaponin B-Ⅱ(100、150mg/kg) could effectively shorten the immobility time in TST and FST,but all dosages showed no significant effect on the spontaneous activity frequency in OFA.Timosaponin B-Ⅱ(150 mg/kg) significantly increased the rate of death of injecting dopamine,but had no obvious effect on the inhibiting reuptake of NE.Timosaponin B-Ⅱ(100、150 mg/kg) enhanced the apomorphine-induced stereotypy remarkably,which with statistically significant differences(P<0.05),and increased the head-twitch response evoked by 5-HTP,but had no effect on the yohimbine toxicity. Conclusion Timosaponin B-Ⅱhas significant antidepressant effect which may be related to the potentiation of brain 5-HT nerve system and DA nerve system.
LU Ming-zhu, ZHANG Zhi-qiang, YI Jia, CHEN Wan-sheng, HOU Zhong-hai, LI Tie-jun. Study on the effect and mechanisms of timosaponin B-Ⅱ on antidepressant[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 283-287.
Citation:
LU Ming-zhu, ZHANG Zhi-qiang, YI Jia, CHEN Wan-sheng, HOU Zhong-hai, LI Tie-jun. Study on the effect and mechanisms of timosaponin B-Ⅱ on antidepressant[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 283-287.
DownLoad: