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Volume 28 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(4): 267-270

ZHANG Jing, SONG Hong-tao, YANG Li-xia, ZHOU Xin. Study on the release in vitro of tacrolimus from the thermosensitive ophthalmic gel[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 267-270.
Citation: ZHANG Jing, SONG Hong-tao, YANG Li-xia, ZHOU Xin. Study on the release in vitro of tacrolimus from the thermosensitive ophthalmic gel[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 267-270.
shu

Study on the release in vitro of tacrolimus from the thermosensitive ophthalmic gel

  • 1.

    Department of Pharmacy,Fuzhou General Hospital of Nanjing Military Region,Fuzhou 350025,China

  • 2.

    Center of Ophthalmology,Fuzhou General Hospital of Nanjing Military Region,Fuzhou 350025,China

  • Received Date: 2009-12-27
  • Rev Recd Date: 2010-04-15
  • Objective To study the factors that influence the release of tacrolimus from the thermosensitive ophthalmic gel. Methods The non-membrane model was introduced to observe the influence on the drug release and gel erosion for surface area and shaking frequency. Results The drug release and gel erosion were increased with the rise of surface area and shaking frequency. Conclusion The drug release mainly depends on the gel erosion.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Study on the release in vitro of tacrolimus from the thermosensitive ophthalmic gel

  • 1. Department of Pharmacy,Fuzhou General Hospital of Nanjing Military Region,Fuzhou 350025,China
  • 2. Center of Ophthalmology,Fuzhou General Hospital of Nanjing Military Region,Fuzhou 350025,China
  • Received Date: 2009-12-27
  • Rev Recd Date: 2010-04-15

Abstract: Objective To study the factors that influence the release of tacrolimus from the thermosensitive ophthalmic gel. Methods The non-membrane model was introduced to observe the influence on the drug release and gel erosion for surface area and shaking frequency. Results The drug release and gel erosion were increased with the rise of surface area and shaking frequency. Conclusion The drug release mainly depends on the gel erosion.

ZHANG Jing, SONG Hong-tao, YANG Li-xia, ZHOU Xin. Study on the release in vitro of tacrolimus from the thermosensitive ophthalmic gel[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 267-270.
Citation: ZHANG Jing, SONG Hong-tao, YANG Li-xia, ZHOU Xin. Study on the release in vitro of tacrolimus from the thermosensitive ophthalmic gel[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 267-270.
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