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Volume 28 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(2): 105-106,121

ZHANG Guo-qing, WANG Ke-bing. Anticancer and phytochemical properties of alkaloids from Caragana microphylla[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 105-106,121.
Citation: ZHANG Guo-qing, WANG Ke-bing. Anticancer and phytochemical properties of alkaloids from Caragana microphylla[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 105-106,121.
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Anticancer and phytochemical properties of alkaloids from Caragana microphylla

  • The 169th hospital of PLA,Hengyang 421002,China

  • Received Date: 2009-10-21
  • Rev Recd Date: 2010-02-19
  • Objective To identify the composition of the total alkaloids of the seeds of Caragana microphylla,a native plant from the North west of China which is used in traditional Mongolian medicines. Methods The alkaloids was separated and identified by chromatographic Methods and spectral analysis.The anticancer activities of the total alkaloids and the isolated protoberberine alkaloids were tested respectively on Saos-2,A375 and Hela cell lines. Results Five protoberberine alkaloids including dehydrothalictrifoline,coptisine,epiberberine,dehydroapocavidine and corysamine were isolated.The totel alkaloids and the 5 alkaloids were found to be very effective against three tumor cell lines. Conclusion s The 5 protoberberine alkaloids were isolated for the first time from Caragana genus.Caragana microphylla seed extracts may play a role as an hopefulanticancer therapeutic agent.
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Anticancer and phytochemical properties of alkaloids from Caragana microphylla

  • The 169th hospital of PLA,Hengyang 421002,China
  • Received Date: 2009-10-21
  • Rev Recd Date: 2010-02-19

Abstract: Objective To identify the composition of the total alkaloids of the seeds of Caragana microphylla,a native plant from the North west of China which is used in traditional Mongolian medicines. Methods The alkaloids was separated and identified by chromatographic Methods and spectral analysis.The anticancer activities of the total alkaloids and the isolated protoberberine alkaloids were tested respectively on Saos-2,A375 and Hela cell lines. Results Five protoberberine alkaloids including dehydrothalictrifoline,coptisine,epiberberine,dehydroapocavidine and corysamine were isolated.The totel alkaloids and the 5 alkaloids were found to be very effective against three tumor cell lines. Conclusion s The 5 protoberberine alkaloids were isolated for the first time from Caragana genus.Caragana microphylla seed extracts may play a role as an hopefulanticancer therapeutic agent.

ZHANG Guo-qing, WANG Ke-bing. Anticancer and phytochemical properties of alkaloids from Caragana microphylla[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 105-106,121.
Citation: ZHANG Guo-qing, WANG Ke-bing. Anticancer and phytochemical properties of alkaloids from Caragana microphylla[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(2): 105-106,121.
shu

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