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Volume 28 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(1): 29-31

NING Wei-wei, LIU Xue-fei, ZHANG Xiao-meng, ZHENG Can-hui, SHENG Chun-quan, ZHOU You-jun, ZHANG Ling, LV Jia-guo, ZHU Ju. Design,synthesis of novel quinazolinon compounds as human anti-acrosin inhibitor[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 296-298,312.
Citation: HOU Ming-ming, SONG Hong-tao, WANG Qing-hua, YANG Shun-liang, TAN Jian-ming. Effect of MDR1C3435T genetic polymorphism on concentration/dose and efficacy of tacrolimus in patients with kidney transplantation[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 29-31.
shu

Effect of MDR1C3435T genetic polymorphism on concentration/dose and efficacy of tacrolimus in patients with kidney transplantation

  • 1.

    Department of Pharmacy,Fuzhou General Hospital of Nanjing Military Region,Fuzhou 350025,China;School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China

  • 2.

    Department of Pharmacy,Fuzhou General Hospital of Nanjing Military Region,Fuzhou 350025,China

  • 3.

    Department of Urology,Fuzhou General Hospital of Nanjing Military Region,Fuzhou 350025,China

  • Received Date: 2009-06-29
  • Rev Recd Date: 2009-08-18
  • Objective To investigate the impact of MDR1C3435T genetic polymorphism on the concentration/dose(C/D) ratio,acute rejection and adverse effect of tacrolimus(FK506)in the renal patients after transplantation. Methods The MDR1C3435T genotype was determined by PCR-RFLP method.The differences of C/D ratio,acute rejection and adverse reaction were compared among all of the genotype groups treated with FK506. Results There was no significant difference in the C/D ratio,rejection and adverse reaction of FK506 among MDR1C3435T genotype groups. Conclusion There was no significant relation between the C/D ratio,acute rejection and adverse reaction of FK506 and MDR1C3435T genetic polymorphism in the transplant patients.
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Effect of MDR1C3435T genetic polymorphism on concentration/dose and efficacy of tacrolimus in patients with kidney transplantation

  • 1. Department of Pharmacy,Fuzhou General Hospital of Nanjing Military Region,Fuzhou 350025,China;School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China
  • 2. Department of Pharmacy,Fuzhou General Hospital of Nanjing Military Region,Fuzhou 350025,China
  • 3. Department of Urology,Fuzhou General Hospital of Nanjing Military Region,Fuzhou 350025,China
  • Received Date: 2009-06-29
  • Rev Recd Date: 2009-08-18

Abstract: Objective To investigate the impact of MDR1C3435T genetic polymorphism on the concentration/dose(C/D) ratio,acute rejection and adverse effect of tacrolimus(FK506)in the renal patients after transplantation. Methods The MDR1C3435T genotype was determined by PCR-RFLP method.The differences of C/D ratio,acute rejection and adverse reaction were compared among all of the genotype groups treated with FK506. Results There was no significant difference in the C/D ratio,rejection and adverse reaction of FK506 among MDR1C3435T genotype groups. Conclusion There was no significant relation between the C/D ratio,acute rejection and adverse reaction of FK506 and MDR1C3435T genetic polymorphism in the transplant patients.

NING Wei-wei, LIU Xue-fei, ZHANG Xiao-meng, ZHENG Can-hui, SHENG Chun-quan, ZHOU You-jun, ZHANG Ling, LV Jia-guo, ZHU Ju. Design,synthesis of novel quinazolinon compounds as human anti-acrosin inhibitor[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(4): 296-298,312.
Citation: HOU Ming-ming, SONG Hong-tao, WANG Qing-hua, YANG Shun-liang, TAN Jian-ming. Effect of MDR1C3435T genetic polymorphism on concentration/dose and efficacy of tacrolimus in patients with kidney transplantation[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 29-31.
shu

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