Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 28 Issue 1
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2010  >  28(1): 7-10

CHEN Jian-ming, DENG Li, WANG Xiu-xin, HUANG Shou, GAO Bao-an, ZHONG Yan-qiang, LU Ying, DING Xue-ying. Experimental design for the prediction of drug validity duration and the investigation of influences on drug stability[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 7-10.
Citation: CHEN Jian-ming, DENG Li, WANG Xiu-xin, HUANG Shou, GAO Bao-an, ZHONG Yan-qiang, LU Ying, DING Xue-ying. Experimental design for the prediction of drug validity duration and the investigation of influences on drug stability[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 7-10.
shu

Experimental design for the prediction of drug validity duration and the investigation of influences on drug stability

  • 1.

    Department of pharmaceutics,School of pharmacy,Second Military Medical University,Shanghai 200433,China

  • 2.

    06 sessions of Unergraduate pharmacy Students,Second Military Medical University,Shanghai 200433,China

  • Received Date: 2009-09-16
  • Rev Recd Date: 2009-10-14
  • Objective To investigate the feasibility of temozolomide replacement of vitamin C and penicillin to evaluate the drug stability for students,experiment;to establish the experimental method to predict the validity duration of temozolomide at room temperature and examine the impact of pH on the validity duration. Methods The concentration of temozolomide was assayed by high performance liquid chromatography(HPLC);the rate equation of first order reaction and Arrhenius equation were used to calculate the correlation parameters. Results Temozolomide was stable under the condition of acidic environment,not under the condition of high temperature,or alkaline environment,respectively;the pH value had a great impact on the drug stability;and the validity duration of temozolomide is about 21 days at room temperature. Conclusion The operation was simple and convenient,and temozolomide was suitable as a model drug to evaluate the drug stability for students,experiment.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2738) PDF downloads(1204) Cited by()

Related
Proportional views

Experimental design for the prediction of drug validity duration and the investigation of influences on drug stability

  • 1. Department of pharmaceutics,School of pharmacy,Second Military Medical University,Shanghai 200433,China
  • 2. 06 sessions of Unergraduate pharmacy Students,Second Military Medical University,Shanghai 200433,China
  • Received Date: 2009-09-16
  • Rev Recd Date: 2009-10-14

Abstract: Objective To investigate the feasibility of temozolomide replacement of vitamin C and penicillin to evaluate the drug stability for students,experiment;to establish the experimental method to predict the validity duration of temozolomide at room temperature and examine the impact of pH on the validity duration. Methods The concentration of temozolomide was assayed by high performance liquid chromatography(HPLC);the rate equation of first order reaction and Arrhenius equation were used to calculate the correlation parameters. Results Temozolomide was stable under the condition of acidic environment,not under the condition of high temperature,or alkaline environment,respectively;the pH value had a great impact on the drug stability;and the validity duration of temozolomide is about 21 days at room temperature. Conclusion The operation was simple and convenient,and temozolomide was suitable as a model drug to evaluate the drug stability for students,experiment.

CHEN Jian-ming, DENG Li, WANG Xiu-xin, HUANG Shou, GAO Bao-an, ZHONG Yan-qiang, LU Ying, DING Xue-ying. Experimental design for the prediction of drug validity duration and the investigation of influences on drug stability[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 7-10.
Citation: CHEN Jian-ming, DENG Li, WANG Xiu-xin, HUANG Shou, GAO Bao-an, ZHONG Yan-qiang, LU Ying, DING Xue-ying. Experimental design for the prediction of drug validity duration and the investigation of influences on drug stability[J]. Journal of Pharmaceutical Practice and Service, 2010, 28(1): 7-10.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return