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LI Ying, YANG Qiu-xia, SUN Jing, ZHENG Wei-qiang, CHEN Jian-ming. Studies on glycolic acid injection resulting in local necrosis of rat livers[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 337-339,372.
Citation:
LI Ying, YANG Qiu-xia, SUN Jing, ZHENG Wei-qiang, CHEN Jian-ming. Studies on glycolic acid injection resulting in local necrosis of rat livers[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 337-339,372.
Studies on glycolic acid injection resulting in local necrosis of rat livers
Department of Pharmaceutics, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
2.
Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
Received Date: 2009-03-11
Abstract
Objective :To observe local necrosis of rat livers resulted from glycolic acid injection and compare necrosis effects resulted from glycolic acid injection and ethanol injection. Methods :After injections of a series of concentrations of glycolic acid and ethanol into rat livers,the mean diameters and the pathologic histology examinations of coagulation necrosis in rat livers were detected. Results :Necrosis occurred around the injection site of glycolic acid.The mean diameter of the necrotic area caused by 5%、10%、15%、20%、30%、40%and 50%glycolic acid was significantly larger than that caused by ethanol(P< 0.05),and pathohistology confirmed that the necrosis was more serious in the former group. Conclusion :Glycolic acid could cause local necrosis of liver,and might be used in clinical practices in the future as a substitute of ethanol for the treatment of liver cancer.
Abstract: Objective :To observe local necrosis of rat livers resulted from glycolic acid injection and compare necrosis effects resulted from glycolic acid injection and ethanol injection. Methods :After injections of a series of concentrations of glycolic acid and ethanol into rat livers,the mean diameters and the pathologic histology examinations of coagulation necrosis in rat livers were detected. Results :Necrosis occurred around the injection site of glycolic acid.The mean diameter of the necrotic area caused by 5%、10%、15%、20%、30%、40%and 50%glycolic acid was significantly larger than that caused by ethanol(P< 0.05),and pathohistology confirmed that the necrosis was more serious in the former group. Conclusion :Glycolic acid could cause local necrosis of liver,and might be used in clinical practices in the future as a substitute of ethanol for the treatment of liver cancer.
LI Ying, YANG Qiu-xia, SUN Jing, ZHENG Wei-qiang, CHEN Jian-ming. Studies on glycolic acid injection resulting in local necrosis of rat livers[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 337-339,372.
Citation:
LI Ying, YANG Qiu-xia, SUN Jing, ZHENG Wei-qiang, CHEN Jian-ming. Studies on glycolic acid injection resulting in local necrosis of rat livers[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(5): 337-339,372.
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