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Volume 27 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(4): 279-281

WANG Jing, WANG Xiao-li, OU Yi-yi, GUO Jun-sheng. Studies on preparation and skin permeation in-vitro of scopolamine hydrobromide microemulsion[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 279-281.
Citation: WANG Jing, WANG Xiao-li, OU Yi-yi, GUO Jun-sheng. Studies on preparation and skin permeation in-vitro of scopolamine hydrobromide microemulsion[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 279-281.
shu

Studies on preparation and skin permeation in-vitro of scopolamine hydrobromide microemulsion

  • Department of Military Hygiene, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2008-11-19
  • Objective :To investigate the physico-chemical properties of scopolamine hydrobromide micromulsion and its transdermal delivery effect in vitro. Methods : The O/W microemulsion was prepared with the system contained of Cremophor RH-40-ethanol-Labrafil-water according to the pseudo-ternary phase diagrams.The values of droplet diameter and viscosity were investigated and the permeation flux of scopolamine hydrobromide was determined in vitro using Franz difusion cel1 with nude rats skin.The content of scopolamine hydrobromide was determined by HPLC. Results :The results indicated that the values of droplet diameter and viscosity and the permeation rate were influenced by the Km value and the contents of oil and water. Conclusion : The highest percutaneous scopolamine hydrobromide absorption microemulsion system with suitable diameter and viscosity contains 30%Cremophor RH-40+ethanol、10%Labrafil M 1944 CS 、1.5% scopolamine hydrobromide and 58.5% water,Km=21.
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Studies on preparation and skin permeation in-vitro of scopolamine hydrobromide microemulsion

  • Department of Military Hygiene, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2008-11-19

Abstract: Objective :To investigate the physico-chemical properties of scopolamine hydrobromide micromulsion and its transdermal delivery effect in vitro. Methods : The O/W microemulsion was prepared with the system contained of Cremophor RH-40-ethanol-Labrafil-water according to the pseudo-ternary phase diagrams.The values of droplet diameter and viscosity were investigated and the permeation flux of scopolamine hydrobromide was determined in vitro using Franz difusion cel1 with nude rats skin.The content of scopolamine hydrobromide was determined by HPLC. Results :The results indicated that the values of droplet diameter and viscosity and the permeation rate were influenced by the Km value and the contents of oil and water. Conclusion : The highest percutaneous scopolamine hydrobromide absorption microemulsion system with suitable diameter and viscosity contains 30%Cremophor RH-40+ethanol、10%Labrafil M 1944 CS 、1.5% scopolamine hydrobromide and 58.5% water,Km=21.

WANG Jing, WANG Xiao-li, OU Yi-yi, GUO Jun-sheng. Studies on preparation and skin permeation in-vitro of scopolamine hydrobromide microemulsion[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 279-281.
Citation: WANG Jing, WANG Xiao-li, OU Yi-yi, GUO Jun-sheng. Studies on preparation and skin permeation in-vitro of scopolamine hydrobromide microemulsion[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 279-281.
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