Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 27 Issue 4
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2009  >  27(4): 276-278

WANG Jin-rui, CHEN Jian-ming, WANG Jian-chao. Pharmacokinetics study of self-emulsifying drug delivery systems of adefovir dipivoxil in rat[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 276-278.
Citation: WANG Jin-rui, CHEN Jian-ming, WANG Jian-chao. Pharmacokinetics study of self-emulsifying drug delivery systems of adefovir dipivoxil in rat[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 276-278.
shu

Pharmacokinetics study of self-emulsifying drug delivery systems of adefovir dipivoxil in rat

  • Department of Pharmaceutics, Schoo1 of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2008-09-22
  • Objective : To study the pharmacokinetics of self-emulsifying drug delivery systems of adefovir dipivoxil in rats. Methods : Six SD rats were randomly divided into two groups for oral administration of the self-emulsifying adefovir dipivoxil and adefovir dipivoxil tablets at a single dose of 100 mg/kg.HPLC method was applied to determine the plasma concentration of these two groups.The calculations of pharmacokinetic parameters were performed with 3P87 program. Results :For the self-emulsifying adefovir dipivoxil,Cmax and AUC were 2.509 4 μg/mL and 277.291 1 μg·min/mL,respectively;while for adefovir sipivoxil tablet,Cmax and AUC were 1.725 8 μg/mL and 215.919 6 μg·min/mL,respectively. Conclusions :The oral bioavailability of the self-emulsifying adefovir dipivoxil was better than tadefovir dipivoxil tablet.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2268) PDF downloads(622) Cited by()

Related
Proportional views

Pharmacokinetics study of self-emulsifying drug delivery systems of adefovir dipivoxil in rat

  • Department of Pharmaceutics, Schoo1 of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2008-09-22

Abstract: Objective : To study the pharmacokinetics of self-emulsifying drug delivery systems of adefovir dipivoxil in rats. Methods : Six SD rats were randomly divided into two groups for oral administration of the self-emulsifying adefovir dipivoxil and adefovir dipivoxil tablets at a single dose of 100 mg/kg.HPLC method was applied to determine the plasma concentration of these two groups.The calculations of pharmacokinetic parameters were performed with 3P87 program. Results :For the self-emulsifying adefovir dipivoxil,Cmax and AUC were 2.509 4 μg/mL and 277.291 1 μg·min/mL,respectively;while for adefovir sipivoxil tablet,Cmax and AUC were 1.725 8 μg/mL and 215.919 6 μg·min/mL,respectively. Conclusions :The oral bioavailability of the self-emulsifying adefovir dipivoxil was better than tadefovir dipivoxil tablet.

WANG Jin-rui, CHEN Jian-ming, WANG Jian-chao. Pharmacokinetics study of self-emulsifying drug delivery systems of adefovir dipivoxil in rat[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 276-278.
Citation: WANG Jin-rui, CHEN Jian-ming, WANG Jian-chao. Pharmacokinetics study of self-emulsifying drug delivery systems of adefovir dipivoxil in rat[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 276-278.
shu

    HTML

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return