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CHEN Zhu-kang, PENG Xin-sheng, CHEN Gui-liang. Study on determination of particulate matter in small volume injections and sterile powder for injection[J]. Journal of Pharmaceutical Practice and Service, 2004, (2): 88-91.
Citation:
WU Wei-feng, YANG Zhi-hui, DAN Zhi-gang, XUE Yun-yun, HU Hong-gang, CHAI Xiao-yun, YU Shi-chong, WU Qiu-ye. Synthesis and antifungal activity of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-(N-cycloproyl-N-benzyl-amino)-2-propanols[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 266-269.
Synthesis and antifungal activity of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-(N-cycloproyl-N-benzyl-amino)-2-propanols
Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
2.
Department of Pharmcy, Air force general hospital, Beijing 100142, China
Received Date: 2009-04-29
Abstract
Objective :Design and synthesis of novel triazole antifungal derivatives based on the structure of fluconazole. Methods : A cyclohexyl group introduced and a series title compounds synthesized All of them were confirmed by MS,1H-NMR,et al.The antifungal activities were also evaluated against the eight common pathogenic fungi. Results :Eleven title compounds were synthesized.Some of the title compounds exhibited activity against fungi tested to some extent. Conclusion :A cyclohexyl group introduced to the side chain affected the antifungal activity.
Abstract: Objective :Design and synthesis of novel triazole antifungal derivatives based on the structure of fluconazole. Methods : A cyclohexyl group introduced and a series title compounds synthesized All of them were confirmed by MS,1H-NMR,et al.The antifungal activities were also evaluated against the eight common pathogenic fungi. Results :Eleven title compounds were synthesized.Some of the title compounds exhibited activity against fungi tested to some extent. Conclusion :A cyclohexyl group introduced to the side chain affected the antifungal activity.
CHEN Zhu-kang, PENG Xin-sheng, CHEN Gui-liang. Study on determination of particulate matter in small volume injections and sterile powder for injection[J]. Journal of Pharmaceutical Practice and Service, 2004, (2): 88-91.
Citation:
WU Wei-feng, YANG Zhi-hui, DAN Zhi-gang, XUE Yun-yun, HU Hong-gang, CHAI Xiao-yun, YU Shi-chong, WU Qiu-ye. Synthesis and antifungal activity of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-(N-cycloproyl-N-benzyl-amino)-2-propanols[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(4): 266-269.
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CHEN Zhu-kang, PENG Xin-sheng, CHEN Gui-liang. Study on determination of particulate matter in small volume injections and sterile powder for injection[J]. Journal of Pharmaceutical Practice and Service, 2004, (2): 88-91.
CHEN Zhu-kang, PENG Xin-sheng, CHEN Gui-liang. Study on determination of particulate matter in small volume injections and sterile powder for injection[J]. Journal of Pharmaceutical Practice and Service, 2004, (2): 88-91.
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