A meta-analysis of treatment of bacterial infections with double-blind randomized clinical study of indigenous gatifloxcin versus levofloxacin

Key words: 
• gastifloxacin /
• levofloxacin /
• double-blind randomized /
• bacterial infections /
• meta-analysis

Abstract: Objective: To estimate the efficacy and safety of indigenous gatifloxacin and levofloxacin on bacterial infection. Methods: According to the requirements of Cochrane systematic review,a thorough literature search was performed among Chinese digital Hospital Library(www.chkd.cnki.net) and Chinese Biomedical Literature Disk Database(CBM disk).A meta analysis was per- formed on a total of 2 253 patients involved in 18 papers which met the inclusion criteria. Results: The clinical effective rate of indige- nous gatifloxacin treatment group versus levofloxacin treatment group was found between the two groups( OR 1.42,95% CI 1.03～1.98,Z=2.11 P=0.03) have significant difference.Clinical cure rates、corresponding bacterial eradication rates and adverse reac- tion rates have no significant difference. Conclusions: Indigenous gatifloxacin treatment bacterial infection effectivenessis higher than levofloxacin.