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Volume 24 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2006  >  (6): 342-345

LV Zhu-fen, XIE Qing-chun, CHEN Yan-zhong, SHEN Lou, ZHOU Song. Pharmacokinetics of cetirizine/pseudoephedrine sustained release tablets in Beagle dogs[J]. Journal of Pharmaceutical Practice and Service, 2006, (6): 342-345.
Citation: LV Zhu-fen, XIE Qing-chun, CHEN Yan-zhong, SHEN Lou, ZHOU Song. Pharmacokinetics of cetirizine/pseudoephedrine sustained release tablets in Beagle dogs[J]. Journal of Pharmaceutical Practice and Service, 2006, (6): 342-345.
shu

Pharmacokinetics of cetirizine/pseudoephedrine sustained release tablets in Beagle dogs

  • 1.

    Institute of Material Medica,Guangdnng College of Pharmacy,Guangzhou 510240,China

  • 2.

    Department of Pharmacy,Guangdong General Hospital,Chinese People's Armed Police,Guangzhou 510507,China

  • Received Date: 2005-12-27
  • Objective: To study the pharmacokinetics of cetirizine/pseudoephedrine sustained release tablets in Beagle dogs. Methods: Pseudoephedrine concentrations in serum were assayed by HPLC with DiamonsilTM C18（250×4.6 mm,5μm） column, 0.05mol/L sodium dihydrogen phosphate-mathanol（75:25）,pH adjusted to 3.0 with phosphoric acid as mobile phase,and detec- tion wavelength of 213nm.The pharmacokinetic parameters were researched after single admininstration of cetirizine/pseudoephedrine sustained release tablets in 6 Beagle dogs. Results: The pharmacokinetic parameters cetirizine/pseudoephedrine sustained release tablets were followed:MRT=8.21 h,Tpeak=4h,Cmax=200 8.7ng/mL.The relative hioavailabihy of cetirizine/pseudoephedrine sustained release tablets was（95.9±2.3）%. Conclusion: The pharmacokinetic profile of cetirizine/pseudoephedrine sustained release tablets was similar to the reference tablets.The self-made one was bioequivalent to Zycted-D 12h tablets,and its released profile in vivo/in vitro was correlation.
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  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

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Pharmacokinetics of cetirizine/pseudoephedrine sustained release tablets in Beagle dogs

  • 1. Institute of Material Medica,Guangdnng College of Pharmacy,Guangzhou 510240,China
  • 2. Department of Pharmacy,Guangdong General Hospital,Chinese People's Armed Police,Guangzhou 510507,China
  • Received Date: 2005-12-27

Abstract: Objective: To study the pharmacokinetics of cetirizine/pseudoephedrine sustained release tablets in Beagle dogs. Methods: Pseudoephedrine concentrations in serum were assayed by HPLC with DiamonsilTM C18（250×4.6 mm,5μm） column, 0.05mol/L sodium dihydrogen phosphate-mathanol（75:25）,pH adjusted to 3.0 with phosphoric acid as mobile phase,and detec- tion wavelength of 213nm.The pharmacokinetic parameters were researched after single admininstration of cetirizine/pseudoephedrine sustained release tablets in 6 Beagle dogs. Results: The pharmacokinetic parameters cetirizine/pseudoephedrine sustained release tablets were followed:MRT=8.21 h,Tpeak=4h,Cmax=200 8.7ng/mL.The relative hioavailabihy of cetirizine/pseudoephedrine sustained release tablets was（95.9±2.3）%. Conclusion: The pharmacokinetic profile of cetirizine/pseudoephedrine sustained release tablets was similar to the reference tablets.The self-made one was bioequivalent to Zycted-D 12h tablets,and its released profile in vivo/in vitro was correlation.

LV Zhu-fen, XIE Qing-chun, CHEN Yan-zhong, SHEN Lou, ZHOU Song. Pharmacokinetics of cetirizine/pseudoephedrine sustained release tablets in Beagle dogs[J]. Journal of Pharmaceutical Practice and Service, 2006, (6): 342-345.
Citation: LV Zhu-fen, XIE Qing-chun, CHEN Yan-zhong, SHEN Lou, ZHOU Song. Pharmacokinetics of cetirizine/pseudoephedrine sustained release tablets in Beagle dogs[J]. Journal of Pharmaceutical Practice and Service, 2006, (6): 342-345.
shu

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