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Volume 24 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2006  >  (6): 342-345

LV Zhu-fen, XIE Qing-chun, CHEN Yan-zhong, SHEN Lou, ZHOU Song. Pharmacokinetics of cetirizine/pseudoephedrine sustained release tablets in Beagle dogs[J]. Journal of Pharmaceutical Practice and Service, 2006, (6): 342-345.
Citation: LV Zhu-fen, XIE Qing-chun, CHEN Yan-zhong, SHEN Lou, ZHOU Song. Pharmacokinetics of cetirizine/pseudoephedrine sustained release tablets in Beagle dogs[J]. Journal of Pharmaceutical Practice and Service, 2006, (6): 342-345.
shu

Pharmacokinetics of cetirizine/pseudoephedrine sustained release tablets in Beagle dogs

  • 1.

    Institute of Material Medica,Guangdnng College of Pharmacy,Guangzhou 510240,China

  • 2.

    Department of Pharmacy,Guangdong General Hospital,Chinese People's Armed Police,Guangzhou 510507,China

  • Received Date: 2005-12-27
  • Objective: To study the pharmacokinetics of cetirizine/pseudoephedrine sustained release tablets in Beagle dogs. Methods: Pseudoephedrine concentrations in serum were assayed by HPLC with DiamonsilTM C18（250×4.6 mm,5μm） column, 0.05mol/L sodium dihydrogen phosphate-mathanol（75:25）,pH adjusted to 3.0 with phosphoric acid as mobile phase,and detec- tion wavelength of 213nm.The pharmacokinetic parameters were researched after single admininstration of cetirizine/pseudoephedrine sustained release tablets in 6 Beagle dogs. Results: The pharmacokinetic parameters cetirizine/pseudoephedrine sustained release tablets were followed:MRT=8.21 h,Tpeak=4h,Cmax=200 8.7ng/mL.The relative hioavailabihy of cetirizine/pseudoephedrine sustained release tablets was（95.9±2.3）%. Conclusion: The pharmacokinetic profile of cetirizine/pseudoephedrine sustained release tablets was similar to the reference tablets.The self-made one was bioequivalent to Zycted-D 12h tablets,and its released profile in vivo/in vitro was correlation.
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    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 95.4 %FULLTEXT: 95.4 %META: 3.5 %META: 3.5 %PDF: 1.1 %PDF: 1.1 %FULLTEXTMETAPDFHighcharts.com
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 34.7 %其他: 34.7 %其他: 0.3 %其他: 0.3 %Baden: 0.2 %Baden: 0.2 %China: 1.1 %China: 1.1 %Nahant: 0.2 %Nahant: 0.2 %[]: 0.3 %[]: 0.3 %三亚: 0.2 %三亚: 0.2 %上海: 1.6 %上海: 1.6 %东莞: 0.2 %东莞: 0.2 %临汾: 0.2 %临汾: 0.2 %丽水: 0.2 %丽水: 0.2 %北京: 13.1 %北京: 13.1 %匹兹堡: 0.2 %匹兹堡: 0.2 %南京: 0.8 %南京: 0.8 %南平: 0.2 %南平: 0.2 %南阳: 0.3 %南阳: 0.3 %台北: 0.2 %台北: 0.2 %台州: 0.2 %台州: 0.2 %哥伦布: 0.2 %哥伦布: 0.2 %墨尔本: 0.2 %墨尔本: 0.2 %密蘇里城: 0.3 %密蘇里城: 0.3 %广州: 0.3 %广州: 0.3 %廊坊: 0.2 %廊坊: 0.2 %张家口: 0.2 %张家口: 0.2 %成都: 0.3 %成都: 0.3 %新乡: 0.2 %新乡: 0.2 %昆明: 0.3 %昆明: 0.3 %普洱: 0.3 %普洱: 0.3 %曼谷: 0.2 %曼谷: 0.2 %朝阳: 0.2 %朝阳: 0.2 %杭州: 0.2 %杭州: 0.2 %沈阳: 0.2 %沈阳: 0.2 %泉州: 0.2 %泉州: 0.2 %洛杉矶: 0.2 %洛杉矶: 0.2 %济源: 0.2 %济源: 0.2 %深圳: 0.2 %深圳: 0.2 %潍坊: 0.2 %潍坊: 0.2 %烟台: 0.2 %烟台: 0.2 %盐城: 0.3 %盐城: 0.3 %石家庄: 0.6 %石家庄: 0.6 %聊城: 0.2 %聊城: 0.2 %芒廷维尤: 18.4 %芒廷维尤: 18.4 %苏州: 0.2 %苏州: 0.2 %衡水: 0.2 %衡水: 0.2 %西宁: 20.6 %西宁: 20.6 %许昌: 0.2 %许昌: 0.2 %赤峰: 0.2 %赤峰: 0.2 %郑州: 0.5 %郑州: 0.5 %都伯林: 0.2 %都伯林: 0.2 %银川: 0.3 %银川: 0.3 %青岛: 0.5 %青岛: 0.5 %龙岩: 0.2 %龙岩: 0.2 %其他其他BadenChinaNahant[]三亚上海东莞临汾丽水北京匹兹堡南京南平南阳台北台州哥伦布墨尔本密蘇里城广州廊坊张家口成都新乡昆明普洱曼谷朝阳杭州沈阳泉州洛杉矶济源深圳潍坊烟台盐城石家庄聊城芒廷维尤苏州衡水西宁许昌赤峰郑州都伯林银川青岛龙岩Highcharts.com
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Pharmacokinetics of cetirizine/pseudoephedrine sustained release tablets in Beagle dogs

  • 1. Institute of Material Medica,Guangdnng College of Pharmacy,Guangzhou 510240,China
  • 2. Department of Pharmacy,Guangdong General Hospital,Chinese People's Armed Police,Guangzhou 510507,China
  • Received Date: 2005-12-27

Abstract: Objective: To study the pharmacokinetics of cetirizine/pseudoephedrine sustained release tablets in Beagle dogs. Methods: Pseudoephedrine concentrations in serum were assayed by HPLC with DiamonsilTM C18（250×4.6 mm,5μm） column, 0.05mol/L sodium dihydrogen phosphate-mathanol（75:25）,pH adjusted to 3.0 with phosphoric acid as mobile phase,and detec- tion wavelength of 213nm.The pharmacokinetic parameters were researched after single admininstration of cetirizine/pseudoephedrine sustained release tablets in 6 Beagle dogs. Results: The pharmacokinetic parameters cetirizine/pseudoephedrine sustained release tablets were followed:MRT=8.21 h,Tpeak=4h,Cmax=200 8.7ng/mL.The relative hioavailabihy of cetirizine/pseudoephedrine sustained release tablets was（95.9±2.3）%. Conclusion: The pharmacokinetic profile of cetirizine/pseudoephedrine sustained release tablets was similar to the reference tablets.The self-made one was bioequivalent to Zycted-D 12h tablets,and its released profile in vivo/in vitro was correlation.

LV Zhu-fen, XIE Qing-chun, CHEN Yan-zhong, SHEN Lou, ZHOU Song. Pharmacokinetics of cetirizine/pseudoephedrine sustained release tablets in Beagle dogs[J]. Journal of Pharmaceutical Practice and Service, 2006, (6): 342-345.
Citation: LV Zhu-fen, XIE Qing-chun, CHEN Yan-zhong, SHEN Lou, ZHOU Song. Pharmacokinetics of cetirizine/pseudoephedrine sustained release tablets in Beagle dogs[J]. Journal of Pharmaceutical Practice and Service, 2006, (6): 342-345.
shu

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