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Volume 23 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2005  >  (4): @-210,223

LIU Qian, GAO Wei, SHANG Bei-cheng. Preparation and enhancement effect of ketoconazole transfersomes on transder-mal absorption[J]. Journal of Pharmaceutical Practice and Service, 2005, (4): @-210,223.
Citation: LIU Qian, GAO Wei, SHANG Bei-cheng. Preparation and enhancement effect of ketoconazole transfersomes on transder-mal absorption[J]. Journal of Pharmaceutical Practice and Service, 2005, (4): @-210,223.
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Preparation and enhancement effect of ketoconazole transfersomes on transder-mal absorption

  • 1.

    Pharmacy Department of General Hospital of PLA, Beijing 100853 China

  • 2.

    Beijing Municipal Institute for Drug Control, Beijing 100035, China

  • 3.

    Kunming General Hospital of Chengdu Military Region, Kunming 650032, China

  • Received Date: 2005-04-25
  • Objective To prepare and determinate the ketoconazole(KCZ)transfersomes(TF),and to study the enhancing effect on the transdermal absorption of ketoconazole transfersomes.Methods The rotary evaporation method was used for preparation of KCZ TF.The HPLC was employed in its determination.The excised rabbit skin was used as the percutaneous barrier, and the modified franz-diffusion cells were used in the test.The enhancement effect of common nano-liposome, transfersomes, 3% dipentene and 3% azone were compared in the transdermal absorption of ketoconazole.Results The KCZ TF were prepared.The sequence of enhancement at difference transdermal enhancer are follows: transfersomes > 3% dipentene > 3% azone > common nana-liposome.Conclusion It was showed that various transder enhancers could promote absorption of ketoconazole in different degrees and transfersomes was the most effective.
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    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 86.8 %FULLTEXT: 86.8 %META: 11.0 %META: 11.0 %PDF: 2.2 %PDF: 2.2 %FULLTEXTMETAPDFHighcharts.com
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 34.6 %其他: 34.6 %China: 1.6 %China: 1.6 %[]: 0.5 %[]: 0.5 %上海: 2.2 %上海: 2.2 %北京: 22.0 %北京: 22.0 %南京: 0.5 %南京: 0.5 %南通: 0.5 %南通: 0.5 %天津: 0.5 %天津: 0.5 %晋城: 0.5 %晋城: 0.5 %杭州: 0.5 %杭州: 0.5 %滁州: 0.5 %滁州: 0.5 %盐城: 0.5 %盐城: 0.5 %福州: 0.5 %福州: 0.5 %芒廷维尤: 12.6 %芒廷维尤: 12.6 %西宁: 21.4 %西宁: 21.4 %青岛: 0.5 %青岛: 0.5 %其他China[]上海北京南京南通天津晋城杭州滁州盐城福州芒廷维尤西宁青岛Highcharts.com
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Preparation and enhancement effect of ketoconazole transfersomes on transder-mal absorption

  • 1. Pharmacy Department of General Hospital of PLA, Beijing 100853 China
  • 2. Beijing Municipal Institute for Drug Control, Beijing 100035, China
  • 3. Kunming General Hospital of Chengdu Military Region, Kunming 650032, China
  • Received Date: 2005-04-25

Abstract: Objective To prepare and determinate the ketoconazole(KCZ)transfersomes(TF),and to study the enhancing effect on the transdermal absorption of ketoconazole transfersomes.Methods The rotary evaporation method was used for preparation of KCZ TF.The HPLC was employed in its determination.The excised rabbit skin was used as the percutaneous barrier, and the modified franz-diffusion cells were used in the test.The enhancement effect of common nano-liposome, transfersomes, 3% dipentene and 3% azone were compared in the transdermal absorption of ketoconazole.Results The KCZ TF were prepared.The sequence of enhancement at difference transdermal enhancer are follows: transfersomes > 3% dipentene > 3% azone > common nana-liposome.Conclusion It was showed that various transder enhancers could promote absorption of ketoconazole in different degrees and transfersomes was the most effective.

LIU Qian, GAO Wei, SHANG Bei-cheng. Preparation and enhancement effect of ketoconazole transfersomes on transder-mal absorption[J]. Journal of Pharmaceutical Practice and Service, 2005, (4): @-210,223.
Citation: LIU Qian, GAO Wei, SHANG Bei-cheng. Preparation and enhancement effect of ketoconazole transfersomes on transder-mal absorption[J]. Journal of Pharmaceutical Practice and Service, 2005, (4): @-210,223.
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