Effect of modafinil on locomotor activity in mice

YU Jia-yue; LIU Yu-mei; ZHANG Xiao-dong

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Volume 23 Issue 3

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2005 > (3): 156-157,175

YU Jia-yue, LIU Yu-mei, ZHANG Xiao-dong. Effect of modafinil on locomotor activity in mice[J]. Journal of Pharmaceutical Practice and Service, 2005, (3): 156-157,175.

Citation:

YU Jia-yue, LIU Yu-mei, ZHANG Xiao-dong. Effect of modafinil on locomotor activity in mice[J]. Journal of Pharmaceutical Practice and Service, 2005, (3): 156-157,175.

Effect of modafinil on locomotor activity in mice

1.
Department of pharmacy 65585 units of PLA, dalian 116104, China
2.
Center of New Drug Evaluation, Second Military Medical University, Shanghai 200433, China

Received Date: 2005-03-03

Abstract

Objective To observe the effect of modafinil on locomotor activity and on CNS in mice.Methods Male mice were used as subjects.Total range of motion, average velocity and linearity were evaluated fay locomotion activity video analysis system.Results Total range of motion, average velocity and linearity were significantly improved after ip 120 mg/kg Modafinil compared to saline treatment.The effect was partial antagonized by sc 60 mg/kg promethamine.Conclusion Modafinil can stimulate CNS in mice which may involve 5-HT system.
- modafinil,
- locomotor activity,
- mice
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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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