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Volume 22 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2004  >  (5): 284-287

FENG Liang, LI Tong-ling, YAN Lin, XU Xiao-hong, ZHANG Rong-qin, ZHENG Peng-cheng, CHENG Qiang. Relative bioavailability of cefixime tablets and capsules in human subjects[J]. Journal of Pharmaceutical Practice and Service, 2004, (5): 284-287.
Citation: FENG Liang, LI Tong-ling, YAN Lin, XU Xiao-hong, ZHANG Rong-qin, ZHENG Peng-cheng, CHENG Qiang. Relative bioavailability of cefixime tablets and capsules in human subjects[J]. Journal of Pharmaceutical Practice and Service, 2004, (5): 284-287.
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Relative bioavailability of cefixime tablets and capsules in human subjects

  • West China School of Pharmacy, Sichuan University, Chengdu 610041, China

  • Received Date: 2003-12-16
  • Objective To compare the bioavailability of cefixime tablets and capsules with Cefspan's (marketed cefixime capsules) in human subjects. Methods A reversed-phase high performance liquid chromatography was used for the determination of cefixime in plasma after a single oral dose of 400mg cefixime tablets,capsules and cefspan in a crossover design. Results The pharmaco-kinetic parameters of cefixime tablets, capsules and cefspan are as follows: AUC0→1(27.29±8.76)μg/mL·h,(28.12±8.91)μg/mL·h and(27.76±8.25)μg/mL·h,AUC0→∞(28.12±9.11)μg/mL·h,(28.98 ±9.33)μg/mL·h and(28.72±8.78)μg/mL·h,tmax(4.00±0.36)h,(4.00±0.35)h and (4.00±0.37)h.Cmax(4.75±1.21)μg/mL,(4.76±1.05)μg/mL and(4.75 ±1.10)μg/mL,t1/2(2.70±0.38)h, (2.65±0.57)h and (2.78±0.61)h, MRT0-T(5.52±0.60)h, (5.57±0.59)h and (5.54±0.57)h. Conclusion The cefixime capsules and tablets are bioequivalent with Cefspan.
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    Created with Highcharts 5.0.7Chart context menuAccess Class DistributionFULLTEXT: 86.2 %FULLTEXT: 86.2 %META: 12.0 %META: 12.0 %PDF: 1.8 %PDF: 1.8 %FULLTEXTMETAPDFHighcharts.com
    Created with Highcharts 5.0.7Chart context menuAccess Area Distribution其他: 24.0 %其他: 24.0 %其他: 0.3 %其他: 0.3 %China: 1.5 %China: 1.5 %[]: 0.9 %[]: 0.9 %上海: 0.9 %上海: 0.9 %北京: 14.5 %北京: 14.5 %印度特伦甘纳邦海得拉巴: 0.6 %印度特伦甘纳邦海得拉巴: 0.6 %厦门: 0.3 %厦门: 0.3 %台州: 0.6 %台州: 0.6 %呼和浩特: 0.3 %呼和浩特: 0.3 %大庆: 0.3 %大庆: 0.3 %太原: 0.3 %太原: 0.3 %宣城: 0.3 %宣城: 0.3 %广州: 0.6 %广州: 0.6 %松原: 0.3 %松原: 0.3 %武汉: 0.3 %武汉: 0.3 %泽西: 0.3 %泽西: 0.3 %洛阳: 0.6 %洛阳: 0.6 %济南: 0.3 %济南: 0.3 %深圳: 0.3 %深圳: 0.3 %潍坊: 0.3 %潍坊: 0.3 %玉林: 0.3 %玉林: 0.3 %白城: 0.3 %白城: 0.3 %石家庄: 0.9 %石家庄: 0.9 %秦皇岛: 0.3 %秦皇岛: 0.3 %红河: 0.6 %红河: 0.6 %聊城: 0.3 %聊城: 0.3 %芒廷维尤: 29.8 %芒廷维尤: 29.8 %芝加哥: 0.3 %芝加哥: 0.3 %西宁: 16.0 %西宁: 16.0 %费利蒙: 0.6 %费利蒙: 0.6 %长沙: 1.2 %长沙: 1.2 %青岛: 0.6 %青岛: 0.6 %鞍山: 0.6 %鞍山: 0.6 %其他其他China[]上海北京印度特伦甘纳邦海得拉巴厦门台州呼和浩特大庆太原宣城广州松原武汉泽西洛阳济南深圳潍坊玉林白城石家庄秦皇岛红河聊城芒廷维尤芝加哥西宁费利蒙长沙青岛鞍山Highcharts.com
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Relative bioavailability of cefixime tablets and capsules in human subjects

  • West China School of Pharmacy, Sichuan University, Chengdu 610041, China
  • Received Date: 2003-12-16

Abstract: Objective To compare the bioavailability of cefixime tablets and capsules with Cefspan's (marketed cefixime capsules) in human subjects. Methods A reversed-phase high performance liquid chromatography was used for the determination of cefixime in plasma after a single oral dose of 400mg cefixime tablets,capsules and cefspan in a crossover design. Results The pharmaco-kinetic parameters of cefixime tablets, capsules and cefspan are as follows: AUC0→1(27.29±8.76)μg/mL·h,(28.12±8.91)μg/mL·h and(27.76±8.25)μg/mL·h,AUC0→∞(28.12±9.11)μg/mL·h,(28.98 ±9.33)μg/mL·h and(28.72±8.78)μg/mL·h,tmax(4.00±0.36)h,(4.00±0.35)h and (4.00±0.37)h.Cmax(4.75±1.21)μg/mL,(4.76±1.05)μg/mL and(4.75 ±1.10)μg/mL,t1/2(2.70±0.38)h, (2.65±0.57)h and (2.78±0.61)h, MRT0-T(5.52±0.60)h, (5.57±0.59)h and (5.54±0.57)h. Conclusion The cefixime capsules and tablets are bioequivalent with Cefspan.

FENG Liang, LI Tong-ling, YAN Lin, XU Xiao-hong, ZHANG Rong-qin, ZHENG Peng-cheng, CHENG Qiang. Relative bioavailability of cefixime tablets and capsules in human subjects[J]. Journal of Pharmaceutical Practice and Service, 2004, (5): 284-287.
Citation: FENG Liang, LI Tong-ling, YAN Lin, XU Xiao-hong, ZHANG Rong-qin, ZHENG Peng-cheng, CHENG Qiang. Relative bioavailability of cefixime tablets and capsules in human subjects[J]. Journal of Pharmaceutical Practice and Service, 2004, (5): 284-287.
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