Studies on assay of roxithromycin in electron medicinal membrane of roxithromycin

Key words: 
• electron medicinal membrane /
• roxithromycin /
• HPLC /
• content determination

Abstract: OBJECTIVE To develop a method for assay of roxithromycin in electron medicinal membrane of roxithromycin. METHODS To use a HPLC method by YWG C₁₈ column. The mobile phase was a mixture of acetonitrile-methano-l0.5% ammonium acetate(100:80:60),with the detection wavelength at 235 nm.RESULTS Precision and stability were fine. The linear correlation was observed from the concentrations of 0.3 to 1.7mg·ml^-1(r=0.9998).The average recovery was 99.23%.Resolution bettween roxithromycin and other peaks met the requirements.CONCLUSION The method is convenient, selective and reproducible.