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Volume 37 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2019  >  37(6): 563-570

LIN Lili, HUANG Aiwen, LIN Meiqin, FANG Jie, SHEN Qinyong, SONG Hongtao. The efficacy and safety of S-1 monotherapy or combined with platinum chemotherapy in the treatment of patients with advanced NSCLC: a meta-analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 563-570. doi: 10.3969/j.issn.1006-0111.2019.06.018
Citation: LIN Lili, HUANG Aiwen, LIN Meiqin, FANG Jie, SHEN Qinyong, SONG Hongtao. The efficacy and safety of S-1 monotherapy or combined with platinum chemotherapy in the treatment of patients with advanced NSCLC: a meta-analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 563-570. doi: 10.3969/j.issn.1006-0111.2019.06.018
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The efficacy and safety of S-1 monotherapy or combined with platinum chemotherapy in the treatment of patients with advanced NSCLC: a meta-analysis

doi: 10.3969/j.issn.1006-0111.2019.06.018
  • 1.

    Department of Pharmacy, 900 Hospital of Joint Logistics Units, Fuzhou 350025, China;Department of Clinical Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China

  • 2.

    Department of Pharmacy, 900 Hospital of Joint Logistics Units, Fuzhou 350025, China

  • Received Date: 2019-02-21
  • Rev Recd Date: 2019-05-14
  • Objective To investigate the efficacy and safety of S-1 monotherapy or combined with platinum chemotherapy in the treatment of patients with advanced NSCLC. Methods Systematic searches were performed for randomized controlled trials with the CNKI,PubMed,Web of Science and Cochrane Library.S-1 monotherapy or combined with platinum chemotherapy was the observation group.Paclitaxel,docetaxel and gemcitabine monotherapy or combined with platinum chemotherapy were the control group.The Cochrane systematic review method was used for literature quality evaluation and RevMan 5.3.5 software was used for statistical analysis. Results 3977 patients were enrolled in 25 studies.The effective rate and disease control rate in the observation group were similar to those in the control group with no statistical significance[ORR:OR=0.97,95% CI (0.83,1.13),P=0.66; DCR:OR=1.11,95% CI (0.92,1.32) P=0.27].In terms of safety,there were less adverse drug reactions in the observation group compared to the control group with statistical significance (P<0.05). Conclusion S-1 monotherapy or combined with platinum chemotherapy is recommended for patients with advanced NSCLC.
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The efficacy and safety of S-1 monotherapy or combined with platinum chemotherapy in the treatment of patients with advanced NSCLC: a meta-analysis

doi: 10.3969/j.issn.1006-0111.2019.06.018
  • 1. Department of Pharmacy, 900 Hospital of Joint Logistics Units, Fuzhou 350025, China;Department of Clinical Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
  • 2. Department of Pharmacy, 900 Hospital of Joint Logistics Units, Fuzhou 350025, China
  • Received Date: 2019-02-21
  • Rev Recd Date: 2019-05-14

Abstract: Objective To investigate the efficacy and safety of S-1 monotherapy or combined with platinum chemotherapy in the treatment of patients with advanced NSCLC. Methods Systematic searches were performed for randomized controlled trials with the CNKI,PubMed,Web of Science and Cochrane Library.S-1 monotherapy or combined with platinum chemotherapy was the observation group.Paclitaxel,docetaxel and gemcitabine monotherapy or combined with platinum chemotherapy were the control group.The Cochrane systematic review method was used for literature quality evaluation and RevMan 5.3.5 software was used for statistical analysis. Results 3977 patients were enrolled in 25 studies.The effective rate and disease control rate in the observation group were similar to those in the control group with no statistical significance[ORR:OR=0.97,95% CI (0.83,1.13),P=0.66; DCR:OR=1.11,95% CI (0.92,1.32) P=0.27].In terms of safety,there were less adverse drug reactions in the observation group compared to the control group with statistical significance (P<0.05). Conclusion S-1 monotherapy or combined with platinum chemotherapy is recommended for patients with advanced NSCLC.

LIN Lili, HUANG Aiwen, LIN Meiqin, FANG Jie, SHEN Qinyong, SONG Hongtao. The efficacy and safety of S-1 monotherapy or combined with platinum chemotherapy in the treatment of patients with advanced NSCLC: a meta-analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 563-570. doi: 10.3969/j.issn.1006-0111.2019.06.018
Citation: LIN Lili, HUANG Aiwen, LIN Meiqin, FANG Jie, SHEN Qinyong, SONG Hongtao. The efficacy and safety of S-1 monotherapy or combined with platinum chemotherapy in the treatment of patients with advanced NSCLC: a meta-analysis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 563-570. doi: 10.3969/j.issn.1006-0111.2019.06.018
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